David Gardner, MD

Professor of Medicine

Publications

  1. Sisley SR, Arble DM, Chambers AP, Gutierrez-Aguilar R, He Y, Xu Y, Gardner D, Moore DD, Seeley RJ, Sandoval DA. Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight. Volume 65 of Issue 9. Diabetes 2016. PMID: 27217488


  2. Glenn DJ, Cardema MC, Gardner DG. Amplification of lipotoxic cardiomyopathy in the VDR gene knockout mouse. Volume 164. The Journal of steroid biochemistry and molecular biology 2015. PMID: 26429397


  3. Ni W, Glenn DJ, Gardner DG. Tie-2Cre mediated deletion of the vitamin D receptor gene leads to improved skeletal muscle insulin sensitivity and glucose tolerance. Volume 164. The Journal of steroid biochemistry and molecular biology 2015. PMID: 26369613


  4. Jeffery LE, Qureshi OS, Gardner D, Hou TZ, Briggs Z, Soskic B, Baker J, Raza K, Sansom DM. Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function. Volume 10 of Issue 7. PloS one 2015. PMID: 26134669


  5. Glenn DJ, Cardema MC, Ni W, Zhang Y, Yeghiazarians Y, Grapov D, Fiehn O, Gardner DG. Cardiac steatosis potentiates angiotensin II effects in the heart. Volume 308 of Issue 4. American journal of physiology. Heart and circulatory physiology 2014. PMID: 25485904


  6. Ni W, Watts SW, Ng M, Chen S, Glenn DJ, Gardner DG. Elimination of vitamin D receptor in vascular endothelial cells alters vascular function. Volume 64 of Issue 6. Hypertension (Dallas, Tex. : 1979) 2014. PMID: 25201890


  7. Gardner DG, Chen S, Glenn DJ. Vitamin D and the heart. Volume 305 of Issue 9. American journal of physiology. Regulatory, integrative and comparative physiology 2013. PMID: 24026071


  8. Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E, Pittas AG, Boland R, Ferrucci L, Bikle DD. Vitamin D: beyond bone. Volume 1287. Annals of the New York Academy of Sciences 2013. PMID: 23682710


  9. Cascino MD, McNabb B, Gardner DG, Woeber KA, Fox AN, Wang B, Fix OK. Acute liver failure with thyrotoxicosis treated with liver transplantation. Volume 19 of Issue 3. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2013. PMID: 23337142


  10. Chen S, Gardner DG. Liganded vitamin D receptor displays anti-hypertrophic activity in the murine heart. Volume 136. The Journal of steroid biochemistry and molecular biology 2012. PMID: 22989481


  11. Thompson IR, Chand AN, King PJ, Ansorge O, Karavitaki N, Jones CA, Rahmutula D, Gardner DG, Zivkovic V, Wheeler-Jones CP, McGonnell IM, Korbonits M, Anderson RA, Wass JA, McNeilly AS, Fowkes RC. Expression of guanylyl cyclase-B (GC-B/NPR2) receptors in normal human fetal pituitaries and human pituitary adenomas implicates a role for C-type natriuretic peptide. Volume 19 of Issue 4. Endocrine-related cancer 2012. PMID: 22645228


  12. Finch JL, Suarez EB, Husain K, Ferder L, Cardema MC, Glenn DJ, Gardner DG, Liapis H, Slatopolsky E. Effect of combining an ACE inhibitor and a VDR activator on glomerulosclerosis, proteinuria, and renal oxidative stress in uremic rats. Volume 302 of Issue 1. American journal of physiology. Renal physiology 2011. PMID: 21957179


  13. Chen S, Law CS, Grigsby CL, Olsen K, Hong TT, Zhang Y, Yeghiazarians Y, Gardner DG. Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy. Volume 124 of Issue 17. Circulation 2011. PMID: 21947295


  14. Glenn DJ, Wang F, Nishimoto M, Cruz MC, Uchida Y, Holleran WM, Zhang Y, Yeghiazarians Y, Gardner DG. A murine model of isolated cardiac steatosis leads to cardiomyopathy. Volume 57 of Issue 2. Hypertension (Dallas, Tex. : 1979) 2011. PMID: 21220706


  15. . Chapter 31 Vitamin D and the Cardiovascular System. 2011. PMID:


  16. Chen S, Law CS, Grigsby CL, Olsen K, Gardner DG. A role for the cell cycle phosphatase Cdc25a in vitamin D-dependent inhibition of adult rat vascular smooth muscle cell proliferation. Volume 122 of Issue 5. The Journal of steroid biochemistry and molecular biology 2010. PMID: 20813185


  17. Chen S, Law CS, Gardner DG. Vitamin D-dependent suppression of endothelin-induced vascular smooth muscle cell proliferation through inhibition of CDK2 activity. Volume 118 of Issue 3. The Journal of steroid biochemistry and molecular biology 2009. PMID: 19961935


  18. Glenn DJ, Rahmutula D, Nishimoto M, Liang F, Gardner DG. Atrial natriuretic peptide suppresses endothelin gene expression and proliferation in cardiac fibroblasts through a GATA4-dependent mechanism. Volume 84 of Issue 2. Cardiovascular research 2009. PMID: 19546173


  19. Chen S, Grigsby CL, Law CS, Ni X, Nekrep N, Olsen K, Humphreys MH, Gardner DG. Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents. Volume 119 of Issue 6. The Journal of clinical investigation 2009. PMID: 19436108


  20. Glenn DJ, Wang F, Chen S, Nishimoto M, Gardner DG. Endothelin-stimulated human B-type natriuretic peptide gene expression is mediated by Yin Yang 1 in association with histone deacetylase 2. Volume 53 of Issue 3. Hypertension (Dallas, Tex. : 1979) 2009. PMID: 19139378


  21. Chen S, Glenn DJ, Ni W, Grigsby CL, Olsen K, Nishimoto M, Law CS, Gardner DG. Expression of the vitamin d receptor is increased in the hypertrophic heart. Volume 52 of Issue 6. Hypertension (Dallas, Tex. : 1979) 2008. PMID: 18936343


  22. Glenn DJ, Gardner DG. Lipids and the heart: neither feast nor famine. Volume 50 of Issue 3. Hypertension (Dallas, Tex. : 1979) 2007. PMID: 17664386


  23. Gardner DG, Chen S, Glenn DJ, Grigsby CL. Molecular biology of the natriuretic peptide system: implications for physiology and hypertension. Volume 49 of Issue 3. Hypertension (Dallas, Tex. : 1979) 2007. PMID: 17283251


  24. . Molecular aspects of the natriuretic peptide system. 2006. PMID:


  25. Fisher LA, Ko N, Miss J, Tung PP, Kopelnik A, Banki NM, Gardner D, Smith WS, Lawton MT, Zaroff JG. Hypernatremia predicts adverse cardiovascular and neurological outcomes after SAH. Volume 5 of Issue 3. Neurocritical care 2006. PMID: 17290085


  26. Chen S, Qiong Y, Gardner DG. A role for p38 mitogen-activated protein kinase and c-myc in endothelin-dependent rat aortic smooth muscle cell proliferation. Volume 47 of Issue 2. Hypertension (Dallas, Tex. : 1979) 2005. PMID: 16365184


  27. Rahmutula D, Gardner DG. C-type natriuretic Peptide down-regulates expression of its cognate receptor in rat aortic smooth muscle cells. Volume 146 of Issue 11. Endocrinology 2005. PMID: 16109786


  28. Chen S, Nakamura K, Gardner DG. 1,25-dihydroxyvitamin D inhibits human ANP gene promoter activity. Volume 128 of Issue 3. Regulatory peptides 2005. PMID: 15837528


  29. Chen S, Ni XP, Humphreys MH, Gardner DG. 1,25 dihydroxyvitamin d amplifies type a natriuretic peptide receptor expression and activity in target cells. Volume 16 of Issue 2. Journal of the American Society of Nephrology : JASN 2004. PMID: 15590756


  30. Xiang W, Kong J, Chen S, Cao LP, Qiao G, Zheng W, Liu W, Li X, Gardner DG, Li YC. Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems. Volume 288 of Issue 1. American journal of physiology. Endocrinology and metabolism 2004. PMID: 15367398


  31. Rahmutula D, Cui J, Chen S, Gardner DG. Transcriptional regulation of type B human natriuretic Peptide receptor gene promoter: dependence on Sp1. Volume 44 of Issue 3. Hypertension (Dallas, Tex. : 1979) 2004. PMID: 15262909


  32. Chen S, McCormick JA, Prabaker K, Wang J, Pearce D, Gardner DG. Sgk1 mediates osmotic induction of NPR-A gene in rat inner medullary collecting duct cells. Volume 43 of Issue 4. Hypertension (Dallas, Tex. : 1979) 2004. PMID: 15007040


  33. Chen S, Gardner DG. Suppression of WEE1 and stimulation of CDC25A correlates with endothelin-dependent proliferation of rat aortic smooth muscle cells. Volume 279 of Issue 14. The Journal of biological chemistry 2004. PMID: 14742443


  34. Anderson HD, Wang F, Gardner DG. Role of the epidermal growth factor receptor in signaling strain-dependent activation of the brain natriuretic peptide gene. Volume 279 of Issue 10. The Journal of biological chemistry 2003. PMID: 14645255


  35. Gardner DG. Natriuretic peptides: markers or modulators of cardiac hypertrophy? Volume 14 of Issue 9. Trends in endocrinology and metabolism: TEM 2003. PMID: 14580760


  36. Anderson HD, Rahmutula D, Gardner DG. Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells. Volume 279 of Issue 2. The Journal of biological chemistry 2003. PMID: 14581470


  37. Liang F, Wang F, Zhang S, Gardner DG. Peroxisome proliferator activated receptor (PPAR)alpha agonists inhibit hypertrophy of neonatal rat cardiac myocytes. Volume 144 of Issue 9. Endocrinology 2003. PMID: 12933694


  38. Gardner DG. Brain natriuretic peptide: a marker for subclinical cardiovascular disease? Volume 114 of Issue 4. The American journal of medicine 2003. PMID: 12681464


  39. Ilic D, Kovacic B, McDonagh S, Jin F, Baumbusch C, Gardner DG, Damsky CH. Focal adhesion kinase is required for blood vessel morphogenesis. Volume 92 of Issue 3. Circulation research 2003. PMID: 12595342


  40. Liang F, Webb P, Marimuthu A, Zhang S, Gardner DG. Triiodothyronine increases brain natriuretic peptide (BNP) gene transcription and amplifies endothelin-dependent BNP gene transcription and hypertrophy in neonatal rat ventricular myocytes. Volume 278 of Issue 17. The Journal of biological chemistry 2003. PMID: 12562779


  41. Ye Q, Chen S, Gardner DG. Endothelin inhibits NPR-A and stimulates eNOS gene expression in rat IMCD cells. Volume 41 of Issue 3 Pt 2. Hypertension (Dallas, Tex. : 1979) 2002. PMID: 12623978


  42. Chen S, Cao L, Intengan HD, Humphreys M, Gardner DG. Osmoregulation of endothelial nitric-oxide synthase gene expression in inner medullary collecting duct cells. Role in activation of the type A natriuretic peptide receptor. Volume 277 of Issue 36. The Journal of biological chemistry 2002. PMID: 12082097


  43. Gardner DG. Manipulating the renin-angiotensin system: more than we bargained for? The American journal of medicine 2002. PMID: 11835956


  44. Francisco A. R. Neves, Ralph R. Cavalieri, Luiz A. Simeoni, David G. Gardner, John D. Baxter, Bruce F. Scharschmidt, Noureddine Lomri, Ralff C. J. Ribeiro. Thyroid Hormone Export Varies among Primary Cells and Appears to Differ from Hormone Uptake. Endocrinology 2002. PMID:


  45. Neves FA, Cavalieri RR, Simeoni LA, Gardner DG, Baxter JD, Scharschmidt BF, Lomri N, Ribeiro RC. Thyroid hormone export varies among primary cells and appears to differ from hormone uptake. Volume 143 of Issue 2. Endocrinology 2002. PMID: 11796501


  46. Kovacic-Milivojevic B, Damsky CC, Gardner DG, Ilic D. Requirements for the localization of p130 Cas to Z-lines in cardiac myocytes. Volume 7 of Issue 2. Cellular & molecular biology letters 2002. PMID: 12097978


  47. Chen S, Gardner DG. Osmoregulation of natriuretic peptide receptor signaling in inner medullary collecting duct. A requirement for p38 MAPK. Volume 277 of Issue 8. The Journal of biological chemistry 2001. PMID: 11744737


  48. . Sp1 Dependence of Natriuretic Peptide Receptor A Gene Transcription in Rat Aortic Smooth Muscle Cells
    1.     1999. PMID:


  49. Faquan Liang, Fred Schaufele, David G. Gardner. Sp1 Dependence of Natriuretic Peptide Receptor A Gene Transcription in Rat Aortic Smooth Muscle Cells*. Endocrinology 1999. PMID:


  50. . Natriuretic Peptides and the Heart. 1999. PMID:


  51. . Cellular and Molecular Aspects of the A-Type Natriuretic Peptide. 1997. PMID:


  52. Branka Kovacic-Milivojevic, David G. Gardner. Divergent Regulation of the Human Atrial Natriuretic Peptide Gene by c-jun and c-fos. Molecular and cellular biology 1992. PMID:


  53. B Kovacic-Milivojevic, D G Gardner. Divergent regulation of the human atrial natriuretic peptide gene by c-jun and c-fos. 1992. PMID:


  54. J P Valentin, DG Gardner, J Ribstein, A Mimran, M.H Humphreys. 42 Extravascular shift of fluid and albumin induced by endothelin in binephrectomized rats. Journal of hypertension 1991. PMID:


  55. John D. Baxter, John A. Lewicki, David G. Gardner. Atrial Natriuretic Peptide. 1988. PMID:


  56. . THE GROWTH HORMONE GENE FAMILY: STRUCTURE, EVOLUTION, EXPRESSION, AND REGULATION11This work was supported by NIH Grants AM19997 and AM18878 and NSF Grant 8004735. 1982. PMID: