Harold Chapman, MD

Professor

I have had a longstanding interest and productive history in the field of tissue remodeling, particularly as it relates to lung disease and have been continuously RO1 funded since 1991. I have also had virtually two research lives. For many years my work primarily focused on proteolytic enzymes. My group cloned and characterized several new members of the cathepsin family and elucidated their roles in bone, lung, and immune disorders. I also pursued basic mechanisms by which proteases and adhesion receptors coordinate cell invasion and extracellular matrix remodeling. We were the first to recognize a physical association between proteases (urokinase) and integrins important to migration and invasion. However, after moving to UCSF I have focused my lab on epithelial biology and in particularly pulmonary fibrosis as a disorder of great, unmet medical need and a logical extension of my prior work in matrix biology. I led in vivo investigations of the role of epithelial mesenchymal transition (EMT) in pulmonary fibrosis and in the course of studying epithelial plasticity we discovered a population of lung epithelial progenitors expressing the integrin alpha6/beta4 capable of regenerative activity in vitro and in vivo in response to major injury. Follow-up studies referenced below led to the discovery that the actual stem/progenitor cells are relatively rare distal airway epithelial subpopulations low in mature lineage markers, identifiable in mice by high levels of the Class I antigen H2K-1, and capable of rapid mobilization, proliferation, and pluripotent differentiation in vivo. In humans we have recently identified Type II cells as much more plastic than that of mice, capable of transdiifferentiation and expansion as metaplastic basal cells after major injury. So, in mice airway progenitors mobilize and migrate into alveoli. In humans, alveolar Type II cells transdifferentiate and execute early lung repair locally. This is a surprising finding that is likely to be a major lab focus for the next several years. My lab now is comprised of mainly PhD trainees and research faculty. We are committed to a mechanistic understanding of the cellular basis of alveolar regeneration after lung injury.

I have trained over twenty PhD and/or MD post-docs who now populate academic departments and pharmaceutical labs. As a physician scientist myself, I have particularly enjoyed the responsibility of motivating and training capable young physicians for careers in disease-oriented research. These now include Division and Department Chairs as well as several independent medicine faculty with successful NIH-funded research programs.

Education
06/80 - Internal Medicine and Pulmonary Critical Care, University of Utah
MD, 06/72 - Medicine, University of Alabama Schooll of Medicine
Honors and Awards
  • Merit Award, National Institute of Health, 2001-2012
  • American Association of Physicians, 1998
  • American Society for Clinical Investigation, 1987
Websites
Publications

  1. Cohen ML, Brumwell AN, Ho TC, Garakani K, Montas G, Leong D, Ding VW, Golden JA, Trinh BN, Jablons DM, Matthay MA, Jones KD, Wolters PJ, Wei Y, Chapman HA, Jourdan Le Saux C. A fibroblast-dependent TGFß1/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis. The Journal of clinical investigation 2024. PMID: 38980870


  2. Jourdan Le Saux C, Ho TC, Brumwell AM, Kathiriya JJ, Wei Y, Hughes JB, Garakani K, Atabai K, Auyeung VC, Papa FR, Chapman HA. BCL-2 Modulates IRE1α Activation to Attenuate ER Stress and Pulmonary Fibrosis. American journal of respiratory cell and molecular biology 2023. PMID: 38117250


  3. Cohen ML, Brumwell AN, Ho TC, Montas G, Golden JA, Jones KD, Wolters PJ, Wei Y, Chapman HA, Le Saux CJ. A fibroblast-dependent TGFβ1/sFRP2 noncanonical Wnt signaling axis underlies epithelial metaplasia in idiopathic pulmonary fibrosis. bioRxiv : the preprint server for biology 2023. PMID: 37577522


  4. Basil MC, Cardenas-Diaz FL, Kathiriya JJ, Morley MP, Carl J, Brumwell AN, Katzen J, Slovik KJ, Babu A, Zhou S, Kremp MM, McCauley KB, Li S, Planer JD, Hussain SS, Liu X, Windmueller R, Ying Y, Stewart KM, Oyster M, Christie JD, Diamond JM, Engelhardt JF, Cantu E, Rowe SM, Kotton DN, Chapman HA, Morrisey EE. Human distal airways contain a multipotent secretory cell that can regenerate alveoli. 2022. PMID: 35355013


  5. Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T. Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells. 2021. PMID: 34969962


  6. Chapman HA. Nuclear IL-33 as a growth and survival agent within basal cells. 2021. PMID: 34596050


  7. Bota-Rabassedas N, Banerjee P, Niu Y, Cao W, Luo J, Xi Y, Tan X, Sheng K, Ahn YH, Lee S, Parra ER, Rodriguez-Canales J, Albritton J, Weiger M, Liu X, Guo HF, Yu J, Rodriguez BL, Firestone JJA, Mino B, Creighton CJ, Solis LM, Villalobos P, Raso MG, Sazer DW, Gibbons DL, Russell WK, Longmore GD, Wistuba II, Wang J, Chapman HA, Miller JS, Zong C, Kurie JM. Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity. 2021. PMID: 33882319


  8. Wei Y, Dong W, Jackson J, Ho TC, Le Saux CJ, Brumwell A, Li X, Klesney-Tait J, Cohen ML, Wolters PJ, Chapman HA. Blocking LOXL2 and TGFβ1 signalling induces collagen I turnover in precision-cut lung slices derived from patients with idiopathic pulmonary fibrosis. Thorax 2021. PMID: 33472968


  9. Peng DH, Rodriguez BL, Diao L, Chen L, Wang J, Byers LA, Wei Y, Chapman HA, Yamauchi M, Behrens C, Raso G, Soto LMS, Cuentes ERP, Wistuba II, Kurie JM, Gibbons DL. Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion. Nature communications 2020. PMID: 32908154


  10. Strunz M, Simon LM, Ansari M, Kathiriya JJ, Angelidis I, Mayr CH, Tsidiridis G, Lange M, Mattner LF, Yee M, Ogar P, Sengupta A, Kukhtevich I, Schneider R, Zhao Z, Voss C, Stoeger T, Neumann JHL, Hilgendorff A, Behr J, O'Reilly M, Lehmann M, Burgstaller G, Königshoff M, Chapman HA, Theis FJ, Schiller HB. Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis. Nature communications 2020. PMID: 32678092


  11. Chapman HA, Wei Y, Montas G, Leong D, Golden JA, Trinh BN, Wolters PJ, Le Saux CJ, Jones KD, Hills NK, Foster E, Oldham JM, Linderholm AL, Kotak P, Decaris M, Turner S, Song JW. Reversal of TGFß1-Driven Profibrotic State in Patients with Pulmonary Fibrosis. The New England journal of medicine 2020. PMID: 32160670


  12. Kathiriya JJ, Chapman HA. VEGF Drives the Car toward Better Gas Exchange. Developmental cell 2020. PMID: 32155436


  13. Kathiriya JJ, Brumwell AN, Jackson JR, Tang X, Chapman HA. Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration. Cell stem cell 2020. PMID: 31978363


  14. Wiley CD, Brumwell AN, Davis SS, Jackson JR, Valdovinos A, Calhoun C, Alimirah F, Castellanos CA, Ruan R, Wei Y, Chapman HA, Ramanathan A, Campisi J, Jourdan Le Saux C. Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis. JCI insight 2019. PMID: 31687975


  15. Egia-Mendikute L, Arpa B, Rosell-Mases E, Corral-Pujol M, Carrascal J, Carrillo J, Mora C, Chapman H, Panosa A, Vives-Pi M, Stratmann T, Serreze D, Verdaguer J. B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes. 2019. PMID: 31428087


  16. LaCanna R, Liccardo D, Zhang P, Tragesser L, Wang Y, Cao T, Chapman HA, Morrisey EE, Shen H, Koch WJ, Kosmider B, Wolfson MR, Tian Y. Yap/Taz regulate alveolar regeneration and resolution of lung inflammation. The Journal of clinical investigation 2019. PMID: 30985294


  17. Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR. Small molecule inhibition of IRE1a kinase/RNase has anti-fibrotic effects in the lung. PloS one 2019. PMID: 30625178


  18. Le Saux CJ, Chapman HA. Idiopathic Pulmonary Fibrosis: Cell Death and Inflammation Revisited. American journal of respiratory cell and molecular biology 2018. PMID: 29698615


  19. Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T. Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. The Journal of clinical investigation 2018. PMID: 29999500


  20. Kim KK, Sheppard D, Chapman HA. TGF-ß1 Signaling and Tissue Fibrosis. Volume 10 of Issue 4. Cold Spring Harbor perspectives in biology 2018. PMID: 28432134


  21. Zhou Y, Horowitz JC, Naba A, Ambalavanan N, Atabai K, Balestrini J, Bitterman PB, Corley RA, Ding BS, Engler AJ, Hansen KC, Hagood JS, Kheradmand F, Lin QS, Neptune E, Niklason L, Ortiz LA, Parks WC, Tschumperlin DJ, White ES, Chapman HA, Thannickal VJ. Extracellular matrix in lung development, homeostasis and disease. Matrix biology : journal of the International Society for Matrix Biology 2018. PMID: 29524630


  22. Wei Y, Kim TJ, Peng DH, Duan D, Gibbons DL, Yamauchi M, Jackson JR, Le Saux CJ, Calhoun C, Peters J, Derynck R, Backes BJ, Chapman HA. Fibroblast-specific inhibition of TGF-ß1 signaling attenuates lung and tumor fibrosis. The Journal of clinical investigation 2017. PMID: 28872461


  23. Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay MA, Shannon JM, Chapman HA, Vaughan AE. Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. Nature cell biology 2017. PMID: 28737769


  24. McClendon J, Jansing NL, Redente EF, Gandjeva A, Ito Y, Colgan SP, Ahmad A, Riches DWH, Chapman HA, Mason RJ, Tuder RM, Zemans RL. Hypoxia-Inducible Factor 1a Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury. The American journal of pathology 2017. PMID: 28618253


  25. Vaughan AE, Chapman HA. Failure of Alveolar Type 2 Cell Maintenance Links Neonatal Distress with Adult Lung Disease. American journal of respiratory cell and molecular biology 2017. PMID: 28362148


  26. Kanegai CM, Xi Y, Donne ML, Gotts JE, Driver IH, Amidzic G, Lechner AJ, Jones KD, Vaughan AE, Chapman HA, Rock JR. Persistent Pathology in Influenza-Infected Mouse Lungs. American journal of respiratory cell and molecular biology 2016. PMID: 27689795


  27. Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature 2014. PMID: 25533958


  28. Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R. Innate antiviral host defense attenuates TGF-ß function through IRF3-mediated suppression of Smad signaling. Volume 56 of Issue 6. Molecular cell 2014. PMID: 25526531


  29. Hogan BL, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CC, Niklason L, Calle E, Le A, Randell SH, Rock J, Snitow M, Krummel M, Stripp BR, Vu T, White ES, Whitsett JA, Morrisey EE. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Volume 15 of Issue 2. Cell stem cell 2014. PMID: 25105578


  30. Reiser J, Chapman H. Soluble urokinase-type plasminogen activator receptor in FSGS: stirred but not shaken. Journal of the American Society of Nephrology : JASN 2014. PMID: 24790180


  31. Grove LM, Southern BD, Jin TH, White KE, Paruchuri S, Harel E, Wei Y, Rahaman SO, Gladson CL, Ding Q, Craik CS, Chapman HA, Olman MA. Urokinase-type plasminogen activator receptor (uPAR) ligation induces a raft-localized integrin signaling switch that mediates the hypermotile phenotype of fibrotic fibroblasts. The Journal of biological chemistry 2014. PMID: 24644284


  32. Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP. Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Volume 189 of Issue 2. American journal of respiratory and critical care medicine 2014. PMID: 24160862


  33. Xi Y, Tan K, Brumwell AN, Chen SC, Kim YH, Kim TJ, Wei Y, Chapman HA. Inhibition of epithelial-to-mesenchymal transition and pulmonary fibrosis by methacycline. American journal of respiratory cell and molecular biology 2014. PMID: 23944988


  34. Shum AK, Alimohammadi M, Tan CL, Cheng MH, Metzger TC, Law CS, Lwin W, Perheentupa J, Bour-Jordan H, Carel JC, Husebye ES, De Luca F, Janson C, Sargur R, Dubois N, Kajosaari M, Wolters PJ, Chapman HA, Kämpe O, Anderson MS. BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease. Volume 5 of Issue 206. Science translational medicine 2013. PMID: 24107778


  35. Yang J, Wheeler SE, Velikoff M, Kleaveland KR, LaFemina MJ, Frank JA, Chapman HA, Christensen PJ, Kim KK. Activated alveolar epithelial cells initiate fibrosis through secretion of mesenchymal proteins. Volume 183 of Issue 5. The American journal of pathology 2013. PMID: 24012677


  36. Matthay MA, Anversa P, Bhattacharya J, Burnett BK, Chapman HA, Hare JM, Hei DJ, Hoffman AM, Kourembanas S, McKenna DH, Ortiz LA, Ott HC, Tente W, Thébaud B, Trapnell BC, Weiss DJ, Yuan JX, Blaisdell CJ. Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012. American journal of respiratory and critical care medicine 2013. PMID: 23713908


  37. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Annals of the American Thoracic Society 2013. PMID: 23607856


  38. Smith KR, Dahl HH, Canafoglia L, Andermann E, Damiano J, Morbin M, Bruni AC, Giaccone G, Cossette P, Saftig P, Grötzinger J, Schwake M, Andermann F, Staropoli JF, Sims KB, Mole SE, Franceschetti S, Alexander NA, Cooper JD, Chapman HA, Carpenter S, Berkovic SF, Bahlo M. Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis. Human molecular genetics 2013. PMID: 23297359


  39. Xi Y, Wei Y, Sennino B, Ulsamer A, Kwan I, Brumwell AN, Tan K, Aghi MK, McDonald DM, Jablons DM, Chapman HA. Identification of pY654-ß-catenin as a critical co-factor in hypoxia-inducible factor-1a signaling and tumor responses to hypoxia. Oncogene 2012. PMID: 23246962


  40. Vaughan AE, Chapman HA. Regenerative activity of the lung after epithelial injury. Biochimica et biophysica acta 2012. PMID: 23219956


  41. Chapman HA. Epithelial responses to lung injury: role of the extracellular matrix. Proceedings of the American Thoracic Society 2012. PMID: 22802280


  42. Sennino B, Ishiguro-Oonuma T, Wei Y, Naylor RM, Williamson CW, Bhagwandin V, Tabruyn SP, You WK, Chapman HA, Christensen JG, Aftab DT, McDonald DM. Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors. Cancer discovery 2012. PMID: 22585997


  43. Ulsamer A, Wei Y, Kim KK, Tan K, Wheeler S, Xi Y, Thies RS, Chapman HA. Axin pathway activity regulates in vivo pY654-ß-catenin accumulation and pulmonary fibrosis. The Journal of biological chemistry 2011. PMID: 22203675


  44. Chapman HA, Li X, Alexander JP, Brumwell A, Lorizio W, Tan K, Sonnenberg A, Wei Y, Vu TH. Integrin a6ß4 identifies an adult distal lung epithelial population with regenerative potential in mice. Volume 121 of Issue 7. The Journal of clinical investigation 2011. PMID: 21701069


  45. Borok Z, Whitsett JA, Bitterman PB, Thannickal VJ, Kotton DN, Reynolds SD, Krasnow MA, Bianchi DW, Morrisey EE, Hogan BL, Kurie JM, Walker DC, Radisky DC, Nishimura SL, Violette SM, Noble PW, Shapiro SD, Blaisdell CJ, Chapman HA, Kiley J, Gail D, Hoshizaki D. Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. Proceedings of the American Thoracic Society 2011. PMID: 21653526


  46. Chapman HA. Toward lung regeneration. The New England journal of medicine 2011. PMID: 21561353


  47. Marmai C, Sutherland RE, Kim KK, Dolganov GM, Fang X, Kim SS, Jiang S, Golden JA, Hoopes CW, Matthay MA, Chapman HA, Wolters PJ. Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis. American journal of physiology. Lung cellular and molecular physiology 2011. PMID: 21498628


  48. Chapman HA. Epithelial-mesenchymal interactions in pulmonary fibrosis. Annual review of physiology 2011. PMID: 21054168


  49. Zhu S, Gladson CL, White KE, Ding Q, Stewart J, Jin TH, Chapman HA, Olman MA. Urokinase receptor mediates lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins. American journal of physiology. Lung cellular and molecular physiology 2009. PMID: 19411312


  50. Liu Y, Chattopadhyay N, Qin S, Szekeres C, Vasylyeva T, Mahoney ZX, Taglienti M, Bates CM, Chapman HA, Miner JH, Kreidberg JA. Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis. Development (Cambridge, England) 2009. PMID: 19176588


  51. Kim Y, Kugler MC, Wei Y, Kim KK, Li X, Brumwell AN, Chapman HA. Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts. The Journal of cell biology 2009. PMID: 19171760


  52. Kim KK, Wei Y, Szekeres C, Kugler MC, Wolters PJ, Hill ML, Frank JA, Brumwell AN, Wheeler SE, Kreidberg JA, Chapman HA. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. Volume 119 of Issue 1. The Journal of clinical investigation 2008. PMID: 19104148


  53. Tang CH, Hill ML, Brumwell AN, Chapman HA, Wei Y. Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins. Journal of cell science 2008. PMID: 18940913


  54. Ewald SE, Lee BL, Lau L, Wickliffe KE, Shi GP, Chapman HA, Barton GM. The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature 2008. PMID: 18820679


  55. Kim KK, Chapman HA. Endothelin-1 as initiator of epithelial-mesenchymal transition: potential new role for endothelin-1 during pulmonary fibrosis. American journal of respiratory cell and molecular biology 2007. PMID: 17575081


  56. Wei Y, Tang CH, Kim Y, Robillard L, Zhang F, Kugler MC, Chapman HA. Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells. The Journal of biological chemistry 2006. PMID: 17145753


  57. Wang B, Huang X, Wolters PJ, Sun J, Kitamoto S, Yang M, Riese R, Leng L, Chapman HA, Finn PW, David JR, Bucala R, Shi GP. Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses. Journal of immunology (Baltimore, Md. : 1950) 2006. PMID: 17056501


  58. Kim KK, Kugler MC, Wolters PJ, Robillard L, Galvez MG, Brumwell AN, Sheppard D, Chapman HA. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Volume 103 of Issue 35. Proceedings of the National Academy of Sciences of the United States of America 2006. PMID: 16924102


  59. Mallen-St Clair J, Shi GP, Sutherland RE, Chapman HA, Caughey GH, Wolters PJ. Cathepsins L and S are not required for activation of dipeptidyl peptidase I (cathepsin C) in mice. Volume 387 of Issue 8. Biological chemistry 2006. PMID: 16895486


  60. DeMeo D, Mariani T, Lange C, Lake S, Litonjua A, Celedón J, Reilly J, Chapman HA, Sparrow D, Spira A, Beane J, Pinto-Plata V, Speizer FE, Shapiro S, Weiss ST, Silverman EK. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society 2006. PMID: 16921128


  61. Ghosh S, Johnson JJ, Sen R, Mukhopadhyay S, Liu Y, Zhang F, Wei Y, Chapman HA, Stack MS. Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways. The Journal of biological chemistry 2006. PMID: 16510444


  62. Tang CH, Lee JW, Galvez MG, Robillard L, Mole SE, Chapman HA. Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological disease. Molecular and cellular biology 2006. PMID: 16508006


  63. Wang B, Sun J, Kitamoto S, Yang M, Grubb A, Chapman HA, Kalluri R, Shi GP. Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors. The Journal of biological chemistry 2005. PMID: 16365041


  64. Demeo DL, Mariani TJ, Lange C, Srisuma S, Litonjua AA, Celedon JC, Lake SL, Reilly JJ, Chapman HA, Mecham BH, Haley KJ, Sylvia JS, Sparrow D, Spira AE, Beane J, Pinto-Plata V, Speizer FE, Shapiro SD, Weiss ST, Silverman EK. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. American journal of human genetics 2005. PMID: 16358219


  65. Chapman HA. Endosomal proteases in antigen presentation. Current opinion in immunology 2005. PMID: 16338127


  66. Kala M, Chen CR, McLachlan SM, Rapoport B, Aliesky H, Chapman HA. Cathepsin S is not crucial to TSHR processing and presentation in a murine model of Graves' disease. Immunology 2005. PMID: 16313367


  67. Kelleher CM, Silverman EK, Broekelmann T, Litonjua AA, Hernandez M, Sylvia JS, Stoler J, Reilly JJ, Chapman HA, Speizer FE, Weiss ST, Mecham RP, Raby BA. A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease. American journal of respiratory cell and molecular biology 2005. PMID: 16081882


  68. Zheng T, Kang MJ, Crothers K, Zhu Z, Liu W, Lee CG, Rabach LA, Chapman HA, Homer RJ, Aldous D, De Sanctis GT, Desanctis G, Underwood S, Graupe M, Flavell RA, Schmidt JA, Elias JA. Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema. Journal of immunology (Baltimore, Md. : 1950) 2005. PMID: 15944319


  69. Yang H, Kala M, Scott BG, Goluszko E, Chapman HA, Christadoss P. Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis. Journal of immunology (Baltimore, Md. : 1950) 2005. PMID: 15661938


  70. Wei Y, Czekay RP, Robillard L, Kugler MC, Zhang F, Kim KK, Xiong JP, Humphries MJ, Chapman HA. Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding. The Journal of cell biology 2005. PMID: 15684035


  71. Sukhova GK, Wang B, Libby P, Pan JH, Zhang Y, Grubb A, Fang K, Chapman HA, Shi GP. Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice. Circulation research 2005. PMID: 15653570


  72. Aslanian AM, Chapman HA, Charo IF. Transient role for CD1d-restricted natural killer T cells in the formation of atherosclerotic lesions. Arteriosclerosis, thrombosis, and vascular biology 2004. PMID: 15591216


  73. DeMeo DL, Celedón JC, Lange C, Reilly JJ, Chapman HA, Sylvia JS, Speizer FE, Weiss ST, Silverman EK. Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine 2004. PMID: 15347563


  74. Pan JH, Sukhova GK, Yang JT, Wang B, Xie T, Fu H, Zhang Y, Satoskar AR, David JR, Metz CN, Bucala R, Fang K, Simon DI, Chapman HA, Libby P, Shi GP. Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 2004. PMID: 15197138


  75. Celedón JC, Lange C, Raby BA, Litonjua AA, Palmer LJ, DeMeo DL, Reilly JJ, Kwiatkowski DJ, Chapman HA, Laird N, Sylvia JS, Hernandez M, Speizer FE, Weiss ST, Silverman EK. The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Human molecular genetics 2004. PMID: 15175276


  76. Chapman HA. Cathepsins as transcriptional activators? Developmental cell 2004. PMID: 15130484


  77. DeMeo DL, Carey VJ, Chapman HA, Reilly JJ, Ginns LC, Speizer FE, Weiss ST, Silverman EK. Familial aggregation of FEF(25-75) and FEF(25-75)/FVC in families with severe, early onset COPD. Thorax 2004. PMID: 15115866


  78. DeClerck YA, Mercurio AM, Stack MS, Chapman HA, Zutter MM, Muschel RJ, Raz A, Matrisian LM, Sloane BF, Noel A, Hendrix MJ, Coussens L, Padarathsingh M. Proteases, extracellular matrix, and cancer: a workshop of the path B study section. The American journal of pathology 2004. PMID: 15039201


  79. Chapman HA. Disorders of lung matrix remodeling. The Journal of clinical investigation 2004. PMID: 14722604


  80. Zhang F, Tom CC, Kugler MC, Ching TT, Kreidberg JA, Wei Y, Chapman HA. Distinct ligand binding sites in integrin alpha3beta1 regulate matrix adhesion and cell-cell contact. The Journal of cell biology 2003. PMID: 14557254


  81. Henningsson F, Wolters P, Chapman HA, Caughey GH, Pejler G. Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5. Volume 384 of Issue 10-11. Biological chemistry 2003. PMID: 14669996


  82. Filippov S, Caras I, Murray R, Matrisian LM, Chapman HA, Shapiro S, Weiss SJ. Matrilysin-dependent elastolysis by human macrophages. The Journal of experimental medicine 2003. PMID: 12963695


  83. Palmer LJ, Celedón JC, Chapman HA, Speizer FE, Weiss ST, Silverman EK. Genome-wide linkage analysis of bronchodilator responsiveness and post-bronchodilator spirometric phenotypes in chronic obstructive pulmonary disease. Human molecular genetics 2003. PMID: 12719384


  84. Shi GP, Sukhova GK, Kuzuya M, Ye Q, Du J, Zhang Y, Pan JH, Lu ML, Cheng XW, Iguchi A, Perrey S, Lee AM, Chapman HA, Libby P. Deficiency of the cysteine protease cathepsin S impairs microvessel growth. Circulation research 2003. PMID: 12600886


  85. Kugler MC, Wei Y, Chapman HA. Urokinase receptor and integrin interactions. Current pharmaceutical design 2003. PMID: 12871068


  86. Stüve O, Youssef S, Slavin AJ, King CL, Patarroyo JC, Hirschberg DL, Brickey WJ, Soos JM, Piskurich JF, Chapman HA, Zamvil SS. The role of the MHC class II transactivator in class II expression and antigen presentation by astrocytes and in susceptibility to central nervous system autoimmune disease. Journal of immunology (Baltimore, Md. : 1950) 2002. PMID: 12471103


  87. Crystal RG, Bitterman PB, Mossman B, Schwarz MI, Sheppard D, Almasy L, Chapman HA, Friedman SL, King TE, Leinwand LA, Liotta L, Martin GR, Schwartz DA, Schultz GS, Wagner CR, Musson RA. Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group. Volume 166 of Issue 2. American journal of respiratory and critical care medicine 2002. PMID: 12119236


  88. Wu ZQ, Shen Y, Khan AQ, Chu CL, Riese R, Chapman HA, Kanagawa O, Snapper CM. The mechanism underlying T cell help for induction of an antigen-specific in vivo humoral immune response to intact Streptococcus pneumoniae is dependent on the type of antigen. Journal of immunology (Baltimore, Md. : 1950) 2002. PMID: 12023350


  89. Mathieu MA, Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH. Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries. Molecular and biochemical parasitology 2002. PMID: 11985866


  90. Silverman EK, Palmer LJ, Mosley JD, Barth M, Senter JM, Brown A, Drazen JM, Kwiatkowski DJ, Chapman HA, Campbell EJ, Province MA, Rao DC, Reilly JJ, Ginns LC, Speizer FE, Weiss ST. Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease. American journal of human genetics 2002. PMID: 11914989


  91. Silverman EK, Mosley JD, Palmer LJ, Barth M, Senter JM, Brown A, Drazen JM, Kwiatkowski DJ, Chapman HA, Campbell EJ, Province MA, Rao DC, Reilly JJ, Ginns LC, Speizer FE, Weiss ST. Genome-wide linkage analysis of severe, early-onset chronic obstructive pulmonary disease: airflow obstruction and chronic bronchitis phenotypes. Human molecular genetics 2002. PMID: 11912177


  92. Zhu S, Gladson CL, Stewart J, White KE, Chapman HA, Olman MA. Adenovirally mediated expression of urokinase receptor binding site on integrin alpha-chain blocks adhesion and migration of human lung fibroblasts. Chest 2002. PMID: 11893675


  93. Fong S, Doyle MV, Goodson RJ, Drummond RJ, Stratton JR, McGuire L, Doyle LV, Chapman HA, Rosenberg S. Random peptide bacteriophage display as a probe for urokinase receptor ligands. Biological chemistry 2002. PMID: 11928809


  94. Riese RJ, Shi GP, Villadangos J, Stetson D, Driessen C, Lennon-Dumenil AM, Chu CL, Naumov Y, Behar SM, Ploegh H, Locksley R, Chapman HA. Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S. Volume 15 of Issue 6. Immunity 2001. PMID: 11754813


  95. Wei Y, Eble JA, Wang Z, Kreidberg JA, Chapman HA. Urokinase receptors promote beta1 integrin function through interactions with integrin alpha3beta1. Molecular biology of the cell 2001. PMID: 11598185


  96. Chapman HA, Wei Y. Protease crosstalk with integrins: the urokinase receptor paradigm. Thrombosis and haemostasis 2001. PMID: 11486997


  97. Fernández PL, Farré X, Nadal A, Fernández E, Peiró N, Sloane BF, Shi GP, Chapman HA, Campo E, Cardesa A. Expression of cathepsins B and S in the progression of prostate carcinoma. International journal of cancer 2001. PMID: 11241311


  98. Wang Z, Zheng T, Zhu Z, Homer RJ, Riese RJ, Chapman HA, Shapiro SD, Elias JA. Interferon gamma induction of pulmonary emphysema in the adult murine lung. The Journal of experimental medicine 2000. PMID: 11104801


  99. Silverman EK, Weiss ST, Drazen JM, Chapman HA, Carey V, Campbell EJ, Denish P, Silverman RA, Celedon JC, Reilly JJ, Ginns LC, Speizer FE. Gender-related differences in severe, early-onset chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine 2000. PMID: 11112130


  100. Wolters PJ, Chapman HA. Importance of lysosomal cysteine proteases in lung disease. Respiratory research 2000. PMID: 11667982


  101. Zheng T, Zhu Z, Wang Z, Homer RJ, Ma B, Riese RJ, Chapman HA, Shapiro SD, Elias JA. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. The Journal of clinical investigation 2000. PMID: 11067861


  102. Luke C, Schick C, Tsu C, Whisstock JC, Irving JA, Brömme D, Juliano L, Shi GP, Chapman HA, Silverman GA. Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage. Biochemistry 2000. PMID: 10852705


  103. Chapman HA, Shi GP. Protease injury in the development of COPD: Thomas A. Neff Lecture. Chest 2000. PMID: 10843961


  104. Simon DI, Wei Y, Zhang L, Rao NK, Xu H, Chen Z, Liu Q, Rosenberg S, Chapman HA. Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin function. The Journal of biological chemistry 2000. PMID: 10744708


  105. Shi GP, Bryant RA, Riese R, Verhelst S, Driessen C, Li Z, Bromme D, Ploegh HL, Chapman HA. Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages. The Journal of experimental medicine 2000. PMID: 10748235


  106. Villadangos JA, Driessen C, Shi GP, Chapman HA, Ploegh HL. Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM. The EMBO journal 2000. PMID: 10698930


  107. Waltz DA, Fujita RM, Yang X, Natkin L, Zhuo S, Gerard CJ, Rosenberg S, Chapman HA. Nonproteolytic role for the urokinase receptor in cellular migration in vivo. American journal of respiratory cell and molecular biology 2000. PMID: 10696068


  108. Riese RJ, Chapman HA. Cathepsins and compartmentalization in antigen presentation. Current opinion in immunology 2000. PMID: 10679409


  109. Villadangos JA, Bryant RA, Deussing J, Driessen C, Lennon-Duménil AM, Riese RJ, Roth W, Saftig P, Shi GP, Chapman HA, Peters C, Ploegh HL. Proteases involved in MHC class II antigen presentation. Immunological reviews 1999. PMID: 10631941


  110. Driessen C, Bryant RA, Lennon-Duménil AM, Villadangos JA, Bryant PW, Shi GP, Chapman HA, Ploegh HL. Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells. The Journal of cell biology 1999. PMID: 10562280


  111. Shi GP, Sukhova GK, Grubb A, Ducharme A, Rhode LH, Lee RT, Ridker PM, Libby P, Chapman HA. Cystatin C deficiency in human atherosclerosis and aortic aneurysms. The Journal of clinical investigation 1999. PMID: 10545518


  112. Chapman HA, Wei Y, Simon DI, Waltz DA. Role of urokinase receptor and caveolin in regulation of integrin signaling. Thrombosis and haemostasis 1999. PMID: 10605716


  113. Chapman HA. A Fas pathway to pulmonary fibrosis. The Journal of clinical investigation 1999. PMID: 10393691


  114. Wei Y, Yang X, Liu Q, Wilkins JA, Chapman HA. A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling. The Journal of cell biology 1999. PMID: 10087270


  115. Shi GP, Villadangos JA, Dranoff G, Small C, Gu L, Haley KJ, Riese R, Ploegh HL, Chapman HA. Cathepsin S required for normal MHC class II peptide loading and germinal center development. Immunity 1999. PMID: 10072072


  116. Wang B, Shi GP, Yao PM, Li Z, Chapman HA, Brömme D. Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization. The Journal of biological chemistry 1998. PMID: 9822672


  117. Maurer D, Fiebiger E, Reininger B, Ebner C, Petzelbauer P, Shi GP, Chapman HA, Stingl G. Fc epsilon receptor I on dendritic cells delivers IgE-bound multivalent antigens into a cathepsin S-dependent pathway of MHC class II presentation. Journal of immunology (Baltimore, Md. : 1950) 1998. PMID: 9743330


  118. Sukhova GK, Shi GP, Simon DI, Chapman HA, Libby P. Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. The Journal of clinical investigation 1998. PMID: 9691094


  119. Riese RJ, Mitchell RN, Villadangos JA, Shi GP, Palmer JT, Karp ER, De Sanctis GT, Ploegh HL, Chapman HA. Cathepsin S activity regulates antigen presentation and immunity. The Journal of clinical investigation 1998. PMID: 9616206


  120. Silverman EK, Chapman HA, Drazen JM, Weiss ST, Rosner B, Campbell EJ, O'DONNELL WJ, Reilly JJ, Ginns L, Mentzer S, Wain J, Speizer FE. Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. American journal of respiratory and critical care medicine 1998. PMID: 9620904


  121. Schick C, Pemberton PA, Shi GP, Kamachi Y, Cataltepe S, Bartuski AJ, Gornstein ER, Brömme D, Chapman HA, Silverman GA. Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis. Biochemistry 1998. PMID: 9548757


  122. Chapman HA. Endosomal proteolysis and MHC class II function. Current opinion in immunology 1998. PMID: 9523118


  123. Young PW, Buckle DR, Cantello BC, Chapman H, Clapham JC, Coyle PJ, Haigh D, Hindley RM, Holder JC, Kallender H, Latter AJ, Lawrie KW, Mossakowska D, Murphy GJ, Roxbee Cox L, Smith SA. Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma. The Journal of pharmacology and experimental therapeutics 1998. PMID: 9454824


  124. Chapman HA. Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration. Current opinion in cell biology 1997. PMID: 9330876


  125. Villadangos JA, Riese RJ, Peters C, Chapman HA, Ploegh HL. Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism. The Journal of experimental medicine 1997. PMID: 9254653


  126. Waltz DA, Natkin LR, Fujita RM, Wei Y, Chapman HA. Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin. The Journal of clinical investigation 1997. PMID: 9202057


  127. Gelb BD, Shi GP, Heller M, Weremowicz S, Morton C, Desnick RJ, Chapman HA. Structure and chromosomal assignment of the human cathepsin K gene. Genomics 1997. PMID: 9143502


  128. Chapman HA, Riese RJ, Shi GP. Emerging roles for cysteine proteases in human biology. Annual review of physiology 1997. PMID: 9074757


  129. Simon DI, Rao NK, Xu H, Wei Y, Majdic O, Ronne E, Kobzik L, Chapman HA. Mac-1 (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells. Blood 1996. PMID: 8874219


  130. Wei Y, Lukashev M, Simon DI, Bodary SC, Rosenberg S, Doyle MV, Chapman HA. Regulation of integrin function by the urokinase receptor. Science (New York, N.Y.) 1996. PMID: 8703217


  131. Gelb BD, Shi GP, Chapman HA, Desnick RJ. Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science (New York, N.Y.) 1996. PMID: 8703060


  132. Wong WS, Simon DI, Rosoff PM, Rao NK, Chapman HA. Mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of Mac-1(CD11b/CD18) and urokinase receptor (CD87). Immunology 1996. PMID: 8707356


  133. Riese RJ, Wolf PR, Brömme D, Natkin LR, Villadangos JA, Ploegh HL, Chapman HA. Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading. Immunity 1996. PMID: 8612130


  134. Munger JS, Haass C, Lemere CA, Shi GP, Wong WS, Teplow DB, Selkoe DJ, Chapman HA. Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S. The Biochemical journal 1995. PMID: 7575468


  135. Rao NK, Shi GP, Chapman HA. Urokinase receptor is a multifunctional protein: influence of receptor occupancy on macrophage gene expression. The Journal of clinical investigation 1995. PMID: 7615819


  136. Lemere CA, Munger JS, Shi GP, Natkin L, Haass C, Chapman HA, Selkoe DJ. The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study. The American journal of pathology 1995. PMID: 7717452


  137. Shi GP, Chapman HA, Bhairi SM, DeLeeuw C, Reddy VY, Weiss SJ. Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2. FEBS letters 1995. PMID: 7805878


  138. Wei Y, Waltz DA, Rao N, Drummond RJ, Rosenberg S, Chapman HA. Identification of the urokinase receptor as an adhesion receptor for vitronectin. The Journal of biological chemistry 1994. PMID: 7528215


  139. Chapman HA, Munger JS, Shi GP. The role of thiol proteases in tissue injury and remodeling. American journal of respiratory and critical care medicine 1994. PMID: 7952652


  140. Waltz DA, Chapman HA. Reversible cellular adhesion to vitronectin linked to urokinase receptor occupancy. The Journal of biological chemistry 1994. PMID: 7514182


  141. Shi GP, Webb AC, Foster KE, Knoll JH, Lemere CA, Munger JS, Chapman HA. Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. The Journal of biological chemistry 1994. PMID: 8157683


  142. Levy BD, Romano M, Chapman HA, Reilly JJ, Drazen J, Serhan CN. Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins. The Journal of clinical investigation 1993. PMID: 8376607


  143. Waltz DA, Sailor LZ, Chapman HA. Cytokines induce urokinase-dependent adhesion of human myeloid cells. A regulatory role for plasminogen activator inhibitors. The Journal of clinical investigation 1993. PMID: 8386190


  144. Shi GP, Munger JS, Meara JP, Rich DH, Chapman HA. Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. The Journal of biological chemistry 1992. PMID: 1373132


  145. Munger JS, Shi GP, Mark EA, Chin DT, Gerard C, Chapman HA. A serine esterase released by human alveolar macrophages is closely related to liver microsomal carboxylesterases. The Journal of biological chemistry 1991. PMID: 1918003


  146. Reilly JJ, Chen P, Sailor LZ, Wilcox D, Mason RW, Chapman HA. Cigarette smoking induces an elastolytic cysteine proteinase in macrophages distinct from cathepsin L. The American journal of physiology 1991. PMID: 1872415


  147. Nusrat AR, Chapman HA. An autocrine role for urokinase in phorbol ester-mediated differentiation of myeloid cell lines. The Journal of clinical investigation 1991. PMID: 1847936


  148. Chapman HA. Role of enzyme receptors and inhibitors in regulating proteolytic activities of macrophages. Annals of the New York Academy of Sciences 1991. PMID: 1648325


  149. Chapman HA, Bertozzi P, Sailor LZ, Nusrat AR. Alveolar macrophage urokinase receptors localize enzyme activity to the cell surface. The American journal of physiology 1990. PMID: 2175557


  150. Chapman HA, Yang XL, Sailor LZ, Sugarbaker DJ. Developmental expression of plasminogen activator inhibitor type 1 by human alveolar macrophages. Possible role in lung injury. Journal of immunology (Baltimore, Md. : 1950) 1990. PMID: 2230126


  151. Reilly JJ, Chen P, Sailor LZ, Mason RW, Chapman HA. Uptake of extracellular enzyme by a novel pathway is a major determinant of cathepsin L levels in human macrophages. The Journal of clinical investigation 1990. PMID: 2365815


  152. Bertozzi P, Astedt B, Zenzius L, Lynch K, LeMaire F, Zapol W, Chapman HA. Depressed bronchoalveolar urokinase activity in patients with adult respiratory distress syndrome. The New England journal of medicine 1990. PMID: 2314423


  153. Chapman HA, Reilly JJ, Yee R, Grubb A. Identification of cystatin C, a cysteine proteinase inhibitor, as a major secretory product of human alveolar macrophages in vitro. The American review of respiratory disease 1990. PMID: 2310099


  154. Reilly JJ, Mason RW, Chen P, Joseph LJ, Sukhatme VP, Yee R, Chapman HA. Synthesis and processing of cathepsin L, an elastase, by human alveolar macrophages. The Biochemical journal 1989. PMID: 2930462


  155. Reilly JJ, Chapman HA. Association between alveolar macrophage plasminogen activator activity and indices of lung function in young cigarette smokers. The American review of respiratory disease 1988. PMID: 3202497


  156. Chapman HA, Bertozzi P, Reilly JJ. Role of enzymes mediating thrombosis and thrombolysis in lung disease. Chest 1988. PMID: 3131071


  157. Chapman HA, Ehrhardt MM, Crombie G, Duffy LK. In vitro assay of extracellular matrix elastin degradation. Journal of biochemical and biophysical methods 1988. PMID: 3379243


  158. Chapman HA, Reilly JJ, Kobzik L. Role of plasminogen activator in degradation of extracellular matrix protein by live human alveolar macrophages. The American review of respiratory disease 1988. PMID: 3341631


  159. Chapman HA, Allen CL, Stone OL. Abnormalities in pathways of alveolar fibrin turnover among patients with interstitial lung disease. The American review of respiratory disease 1986. PMID: 3954252


  160. Mason RW, Johnson DA, Barrett AJ, Chapman HA. Elastinolytic activity of human cathepsin L. The Biochemical journal 1986. PMID: 3518704


  161. Chapman HA, Stone OL. A fibrinolytic inhibitor of human alveolar macrophages. Induction with endotoxin. The American review of respiratory disease 1985. PMID: 3898943


  162. Chapman HA, Stone OL. Characterization of a macrophage-derived plasminogen-activator inhibitor. Similarities with placental urokinase inhibitor. The Biochemical journal 1985. PMID: 2932100


  163. Chapman HA, Allen CL, Stone OL, Fair DS. Human alveolar macrophages synthesize factor VII in vitro. Possible role in interstitial lung disease. The Journal of clinical investigation 1985. PMID: 4008651


  164. Chapman HA, Stone OL. Comparison of live human neutrophil and alveolar macrophage elastolytic activity in vitro. Relative resistance of macrophage elastolytic activity to serum and alveolar proteinase inhibitors. The Journal of clinical investigation 1984. PMID: 6568228


  165. Chapman HA, Stone OL. Co-operation between plasmin and elastase in elastin degradation by intact murine macrophages. The Biochemical journal 1984. PMID: 6237643


  166. Chapman HA, Stone OL, Vavrin Z. Degradation of fibrin and elastin by intact human alveolar macrophages in vitro. Characterization of a plasminogen activator and its role in matrix degradation. The Journal of clinical investigation 1984. PMID: 6368589


  167. Chapman HA, Vavrin Z, Hibbs JB. Coordinate expression of macrophage procoagulant and fibrinolytic activity in vitro and in vivo. Journal of immunology (Baltimore, Md. : 1950) 1983. PMID: 6847882


  168. Chapman HA, Vavrin Z, Hibbs JB. Macrophage fibrinolytic activity: identification of two pathways of plasmin formation by intact cells and of a plasminogen activator inhibitor. Cell 1982. PMID: 6210439


  169. Chapman HA, Vavrin Z, Hibbs JB. Modulation of plasminogen activator secretion by activated macrophages: influence of serum factors and correlation with tumoricidal potential. Proceedings of the National Academy of Sciences of the United States of America 1979. PMID: 291048


  170. Weinberg JB, Chapman HA, Hibbs JB. Characterization of the effects of endotoxin on macrophage tumor cell killing. Journal of immunology (Baltimore, Md. : 1950) 1978. PMID: 27559


  171. Chapman HA, Johnson JS, Cooper MD. Ontogeny of Peyer's patches and immunoglobulin-containing cells in pigs. Journal of immunology (Baltimore, Md. : 1950) 1974. PMID: 4591974