Jeffrey Gotts, MD, PhD

Assistant Adjunct Professor

My focus is to improve the care of critically ill patients through my roles as a practicing intensivist, co-director of the medical ICU, and teacher and mentor of resident and fellow clinical trainees. I also conduct basic science investigations of bacterial and viral pneumonia, focusing on mechanisms of injury and recovery.

Education
Residency, - School of Medicine - Internal Medicine, University of California, San Francisco
Publications

  1. Arias-Badia M, Pai CS, Chen P, Chang A, Lwin YM, Srinath A, Gotts JE, Glantz SA, Fong L. E-cigarette exposure disrupts antitumor immunity and promotes metastasis. Frontiers in immunology 2024. PMID: 39221247


  2. Taenaka H, Wick KD, Sarma A, Matsumoto S, Ghale R, Fang X, Maishan M, Gotts JE, Langelier CR, Calfee CS, Matthay MA. Biological effects of corticosteroids on pneumococcal pneumonia in Mice-translational significance. Critical care (London, England) 2024. PMID: 38807178


  3. Taenaka H, Fang X, Maishan M, Trivedi A, Wick KD, Gotts JE, Martin TR, Calfee CS, Matthay MA. Neutrophil Reduction Attenuates the Severity of Lung Injury in the Early Phase of Pneumococcal Pneumonia in Mice. American journal of physiology. Lung cellular and molecular physiology 2024. PMID: 38772909


  4. Taenaka H, Wick KD, Sarma A, Matsumoto S, Ghale R, Fang X, Maishan M, Gotts JE, Langelier CR, Calfee CS, Matthay MA. Biological Effects of Corticosteroids on Pneumococcal Pneumonia in Mice and Humans. Research square 2024. PMID: 38464245


  5. Matthay MA, Arabi Y, Arroliga AC, Bernard G, Bersten AD, Brochard LJ, Calfee CS, Combes A, Daniel BM, Ferguson ND, Gong MN, Gotts JE, Herridge MS, Laffey JG, Liu KD, Machado FR, Martin TR, McAuley DF, Mercat A, Moss M, Mularski RA, Pesenti A, Qiu H, Ramakrishnan N, Ranieri M, Riviello ED, Rubin E, Slutsky A, Thompson BT, Twagirumugabe T, Ware LB, Wick KD. A New Global Definition of Acute Respiratory Distress Syndrome. American journal of respiratory and critical care medicine 2023. PMID: 37487152


  6. Maishan M, Sarma A, Chun LF, Caldera S, Fang X, Abbott J, Christenson SA, Langelier CR, Calfee CS, Gotts JE, Matthay MA. Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection. Frontiers in immunology 2023. PMID: 36999019


  7. Wick KD, Fang X, Maishan M, Matsumoto S, Spottiswoode N, Sarma A, Simoneau C, Khakoo M, Langelier C, Calfee CS, Gotts JE, Matthay MA. Impact of E-Cigarette Aerosol on Primary Human Alveolar Epithelial Type 2 Cells. 2022. PMID: 35670478


  8. Moazed F, Hendrickson C, Jauregui A, Gotts J, Conroy A, Delucchi K, Zhuo H, Arambulo M, Vessel K, Ke S, Deiss T, Ni A, Leligdowicz A, Abbott J, Cohen MJ, Sinha P, Gomez A, Kangelaris K, Kornblith L, Matthay M, Benowitz N, Liu K, Calfee CS. Cigarette Smoke Exposure and ARDS in Sepsis: Epidemiology, Clinical Features, and Biologic Markers. 2022. PMID: 35050845


  9. Matsumoto S, Traber MG, Leonard SW, Choi J, Fang X, Maishan M, Wick KD, Jones KD, Calfee CS, Gotts JE, Matthay MA. Aerosolized Vitamin E Acetate Causes Oxidative Injury in Mice and in Alveolar Macrophages. 2022. PMID: 35318859


  10. Gotts JE, Maishan M, Chun L, Fang X, Han CY, Chiueh V, Khakoo AY, Lee T, Stolina M, Matthay MA. Delayed angiopoietin-2 blockade reduces influenza-induced lung injury and improves survival in mice. 2021. PMID: 34755490


  11. Gomez-Sanchez CM, Wu BX, Gotts JE, Chang RW. Euglycemic diabetic ketoacidosis following major vascular surgery is a new item on the differential for postoperative acidosis. 2021. PMID: 34816071


  12. Siegel ER, Croze RH, Fang X, Matthay MA, Gotts JE. Inhibition of the lipoxin A4 and resolvin D1 receptor impairs host response to acute lung injury caused by pneumococcal pneumonia in mice. American journal of physiology. Lung cellular and molecular physiology 2021. PMID: 33822656


  13. Matsumoto S, Fang X, Traber MG, Jones KD, Langelier C, Hayakawa Serpa P, Calfee CS, Matthay MA, Gotts JE. Dose-Dependent Pulmonary Toxicity of Aerosolized Vitamin E Acetate. American journal of respiratory cell and molecular biology 2020. PMID: 32822237


  14. Ross JT, Nesseler N, Leligdowicz A, Zemans RL, Mahida RY, Minus E, Langelier C, Gotts JE, Matthay MA. THE EX-VIVO PERFUSED HUMAN LUNG IS RESISTANT TO INJURY BY HIGH-DOSE S. PNEUMONIAE BACTEREMIA. American journal of physiology. Lung cellular and molecular physiology 2020. PMID: 32519893


  15. Matthay MA, Aldrich JM, Gotts JE. Treatment for severe acute respiratory distress syndrome from COVID-19. The Lancet. Respiratory medicine 2020. PMID: 32203709


  16. Gotts JE, Jordt SE, McConnell R, Tarran R. What are the respiratory effects of e-cigarettes? BMJ (Clinical research ed.) 2019. PMID: 31570493


  17. Gotts JE, Bernard O, Chun L, Croze RH, Ross JT, Nesseler N, Wu X, Abbott J, Fang X, Calfee CS, Matthay MA. Clinically Relevant Model of Pneumococcal Pneumonia, ARDS, and Non-Pulmonary Organ Dysfunction in Mice. American journal of physiology. Lung cellular and molecular physiology 2019. PMID: 31509438


  18. Matthay MA, Zhuo H, Gotts JE, Liu KD, Calfee CS. Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply. The Lancet. Respiratory medicine 2019. PMID: 30926051


  19. Gotts JE. High-power vaping injures the human lung. American journal of physiology. Lung cellular and molecular physiology 2019. PMID: 30838866


  20. Matthay MA, Calfee CS, Zhuo H, Thompson BT, Wilson JG, Levitt JE, Rogers AJ, Gotts JE, Wiener-Kronish JP, Bajwa EK, Donahoe MP, McVerry BJ, Ortiz LA, Exline M, Christman JW, Abbott J, Delucchi KL, Caballero L, McMillan M, McKenna DH, Liu KD. Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial. The Lancet. Respiratory medicine 2018. PMID: 30455077


  21. Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J. Assessment of industry data on pulmonary and immunosuppressive effects of IQOS. Tobacco control 2018. PMID: 30158203


  22. Chun L, Moazed F, Matthay M, Calfee C, Gotts J. Possible hepatotoxicity of IQOS. Tobacco control 2018. PMID: 30131373


  23. Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA. Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice. American journal of physiology. Lung cellular and molecular physiology 2018. PMID: 29543040


  24. Gotts JE, Matthay MA. Cell-based Therapy in Sepsis. A Step Closer. American journal of respiratory and critical care medicine 2018. PMID: 29072926


  25. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE. Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties". American journal of physiology. Lung cellular and molecular physiology 2017. PMID: 29109110


  26. Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA. Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2017. PMID: 28340238


  27. Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay MA, Shannon JM, Chapman HA, Vaughan AE. Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. Nature cell biology 2017. PMID: 28737769


  28. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE. Pulmonary toxicity of e-cigarettes. American journal of physiology. Lung cellular and molecular physiology 2017. PMID: 28522559


  29. Xu X, Greenland JR, Gotts JE, Matthay MA, Caughey GH. Cathepsin L Helps to Defend Mice from Infection with Influenza A. Volume 11 of Issue 10. PloS one 2016. PMID: 27716790


  30. Kanegai CM, Xi Y, Donne ML, Gotts JE, Driver IH, Amidzic G, Lechner AJ, Jones KD, Vaughan AE, Chapman HA, Rock JR. Persistent Pathology in Influenza-Infected Mouse Lungs. American journal of respiratory cell and molecular biology 2016. PMID: 27689795


  31. Gotts JE, Matthay MA. Sepsis: pathophysiology and clinical management. BMJ (Clinical research ed.) 2016. PMID: 27217054


  32. Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature 2014. PMID: 25533958


  33. Gotts JE, Matthay MA. Endogenous and exogenous cell-based pathways for recovery from acute respiratory distress syndrome. Clinics in chest medicine 2014. PMID: 25453426


  34. Gotts JE, Abbott J, Matthay MA. Influenza causes prolonged disruption of the alveolar-capillary barrier in mice unresponsive to mesenchymal stem cell therapy. American journal of physiology. Lung cellular and molecular physiology 2014. PMID: 25038188


  35. Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA. Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome. Volume 4. Annals of intensive care 2014. PMID: 25593740


  36. Gotts JE, Matthay MA. Treating ARDS: new hope for a tough problem. The Lancet. Respiratory medicine 2013. PMID: 24503258


  37. Gotts JE, Matthay MA. Cell therapy for lung disease: a step forward. Chest 2013. PMID: 23732575


  38. Gotts JE, Matthay MA. Mesenchymal stem cells and the stem cell niche: a new chapter. American journal of physiology. Lung cellular and molecular physiology 2012. PMID: 22505672


  39. Gotts JE, Matthay MA. Mesenchymal stem cells and acute lung injury. Critical care clinics 2011. PMID: 21742225


  40. Gotts JE, Chesselet MF. Mechanisms of subventricular zone expansion after focal cortical ischemic injury. The Journal of comparative neurology 2005. PMID: 15924343


  41. Gotts JE, Chesselet MF. Vascular changes in the subventricular zone after distal cortical lesions. Experimental neurology 2005. PMID: 15899251


  42. Gotts JE, Chesselet MF. Migration and fate of newly born cells after focal cortical ischemia in adult rats. Journal of neuroscience research 2005. PMID: 15751027


  43. Liang Q, Gotts J, Satyamurthy N, Barrio J, Phelps ME, Gambhir SS, Herschman HR. Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus. Molecular therapy : the journal of the American Society of Gene Therapy 2002. PMID: 12095306


  44. Gotts JE, Press C, Leasure JL, Schallert T. Focal brain injury, FGF-2 and the adverse effects of excessive motor demand on cortical and nigral degeneration: marked protection by delayed intermittent exposure to halothane. Journal of neurotrauma 2000. PMID: 11101209


  45. Kawamata T, Dietrich WD, Schallert T, Gotts JE, Cocke RR, Benowitz LI, Finklestein SP. Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction. Proceedings of the National Academy of Sciences of the United States of America 1997. PMID: 9223335