Jesse Nussbaum, MD

Assistant Adjunct Professor

Publications

  1. Nussbaum JC, Hussain A, Butera P, Ford AP, Kitt MM, O'Neill EA, Smith S, Vargas G, O'Reilly T, Wynne C, Stoch SA, Iwamoto M. Single- and Multiple-Dose Pharmacokinetics of Gefapixant (MK-7264), a P2X3 Receptor Antagonist, in Healthy Adults. Journal of clinical pharmacology 2024. PMID: 38651193


  2. Nussbaum J, Cao X, Railkar RA, Sachs JR, Spellman DS, Luk J, Shaw CA, Cejas PJ, Citron MP, Al-Ibrahim M, Han D, Pagnussat S, Stoch SA, Lai E, Bett AJ, Espeseth AS. Evaluation of a stabilized RSV pre-fusion F mRNA vaccine: Preclinical studies and Phase 1 clinical testing in healthy adults. Vaccine 2023. PMID: 37777449


  3. Walford GA, Bautmans A, Cannon C, Duncan KE, Deschamps K, Matthews RP, Nussbaum J, Stoch SA. Considerations for Cell and Gene Therapy Programs Entering the Clinical Space. Clinical pharmacology and therapeutics 2023. PMID: 37309988


  4. Chawla A, Largajolli A, Hussain A, Kleijn H, Ait-Oudhia S, Anton J, Ananthula H, Nussbaum J, La Rosa C, Gheyas F. Population Pharmacokinetic Analysis of the P2X3-Receptor Antagonist Gefapixant. CPT: pharmacometrics & systems pharmacology 2023. PMID: 37147897


  5. Sanchez LA, Tang M, Ahmed A, Nussbaum JC, Nguyen DN, Muskat M, Chen XH, Pham MN. Transition of Care in Inborn Errors of Immunity: Outcomes of a Single-Center Quality Improvement Initiative. The journal of allergy and clinical immunology. In practice 2023. PMID: 37119980


  6. Pruimboom-Brees IM, Gupta S, Chemuturi N, Booler HS, Nimz E, Ferrell Ramos M, Caruso A, Maass KF, Bantseev V, Huang Q, Choules MP, Nussbaum JC, Kanodia J, Thompson C, Durairaj C. International consortium for innovation and quality: An industry perspective on the nonclinical and early clinical development of intravitreal drugs. Clinical and translational science 2023. PMID: 36651217


  7. Nussbaum JC, Hussain A, Min KC, Marbury TC, Lasseter K, Stoch SA, Iwamoto M. Effects of Renal Impairment on the Pharmacokinetics of Gefapixant, a P2×3 Receptor Antagonist. 2022. PMID: 35656754


  8. Nussbaum J, Hussain A, Ford A, Butera P, Kitt M, Smith S, Stoch A, Iwamoto M. A Randomized, Placebo-Controlled Study to Investigate the Safety, Tolerability, and Pharmacokinetics of 3 Weeks of Orally Administered Gefapixant in Healthy Younger and Older Adults. 2022. PMID: 35670873


  9. Gupta P, Hussain A, Ford AP, Smith S, Nussbaum JC, Stoch A, Iwamoto M. Clinical Formulation Bridging of Gefapixant, a P2X3-Receptor Antagonist, for the Treatment of Chronic Cough. 2022. PMID: 35510785


  10. Nussbaum JC, Hussain A, Ma B, Min KC, Chen Q, Tomek C, Iwamoto M, Stoch SA. Characterization of the absorption, metabolism, excretion, and mass balance of gefapixant in humans. 2022. PMID: 35106949


  11. Nussbaum JC, Hussain A, Ma B, Min KC, Evers R, Li Y, Garrett G, Stoch SA, Iwamoto M. Assessment of the Effect of Pyrimethamine, a Potent Inhibitor of Multidrug and Toxin Extrusion Protein 1/2K, on the Pharmacokinetics of Gefapixant (MK-7264), a P2X3 Receptor Antagonist. 2021. PMID: 34145987


  12. Schneider C, Lee J, Koga S, Ricardo-Gonzalez RR, Nussbaum JC, Smith LK, Villeda SA, Liang HE, Locksley RM. Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming. Immunity 2019. PMID: 31128962


  13. Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM. Tissue signals imprint ILC2 identity with anticipatory function. Nature immunology 2018. PMID: 30201992


  14. . 1021 Origin of type 2 innate lymphoid cells in the skin. 2018. PMID:


  15. Nussbaum JC, Ortiz-Carpena JF. Isolation and Identification of Group 2 Innate Lymphoid Cells in Settings of Type 2 Inflammation. Methods in molecular biology (Clifton, N.J.) 2018. PMID: 29956147


  16. . LB973 Characterization of tissue-resident ILC2 heterogeneity in homeostasis. 2017. PMID:


  17. Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM. A tissue checkpoint regulates type 2 immunity. Volume 17 of Issue 12. Nature immunology 2016. PMID: 27749840


  18. Hindi SM, Wang Y, Jones KD, Nussbaum JC, Chang Y, Masharani U, Bikle D, Shoback DM, Hsiao EC. A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting. Volume 97 of Issue 6. Calcified tissue international 2015. PMID: 26253396


  19. Mohapatra A, Van Dyken SJ, Schneider C, Nussbaum JC, Liang HE, Locksley RM. Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis. Volume 9 of Issue 1. Mucosal immunology 2015. PMID: 26129648


  20. Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley RM. Interleukin-33 and Interferon-? Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Volume 43 of Issue 1. Immunity 2015. PMID: 26092469


  21. Lee MW, Odegaard JI, Mukundan L, Qiu Y, Molofsky AB, Nussbaum JC, Yun K, Locksley RM, Chawla A. Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Volume 160 of Issue 1-2. Cell 2014. PMID: 25543153


  22. Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM. Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and ?d T cells. Volume 40 of Issue 3. Immunity 2014. PMID: 24631157


  23. Jarvis JN, Bicanic T, Loyse A, Namarika D, Jackson A, Nussbaum JC, Longley N, Muzoora C, Phulusa J, Taseera K, Kanyembe C, Wilson D, Hosseinipour MC, Brouwer AE, Limmathurotsakul D, White N, van der Horst C, Wood R, Meintjes G, Bradley J, Jaffar S, Harrison T. Determinants of mortality in a combined cohort of 501 patients with HIV-associated Cryptococcal meningitis: implications for improving outcomes. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2013. PMID: 24319084


  24. Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM. Type 2 innate lymphoid cells control eosinophil homeostasis. Volume 502 of Issue 7470. Nature 2013. PMID: 24037376


  25. . 265 Cooperative activation of innate lymphoid type 2 cells (ILC2) by epithelial cytokines in response to chitin. 2013. PMID:


  26. Bando JK, Nussbaum JC, Liang HE, Locksley RM. Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung. Volume 94 of Issue 5. Journal of leukocyte biology 2013. PMID: 23924659


  27. Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. Volume 210 of Issue 3. The Journal of experimental medicine 2013. PMID: 23420878


  28. Jackson AT, Nussbaum JC, Phulusa J, Namarika D, Chikasema M, Kanyemba C, Jarvis JN, Jaffar S, Hosseinipour MC, van der Horst C, Harrison TS. A phase II randomized controlled trial adding oral flucytosine to high-dose fluconazole, with short-course amphotericin B, for cryptococcal meningitis. AIDS (London, England) 2012. PMID: 22526517


  29. Nussbaum JC, Locksley RM. Infectious (Non)tolerance--frustrated commensalism gone awry? Volume 4 of Issue 5. Cold Spring Harbor perspectives in biology 2012. PMID: 22456498


  30. Nussbaum JC, Jackson A, Namarika D, Phulusa J, Kenala J, Kanyemba C, Jarvis JN, Jaffar S, Hosseinipour MC, Kamwendo D, van der Horst CM, Harrison TS. Combination flucytosine and high-dose fluconazole compared with fluconazole monotherapy for the treatment of cryptococcal meningitis: a randomized trial in Malawi. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2010. PMID: 20038244


  31. Idnurm A, Reedy JL, Nussbaum JC, Heitman J. Cryptococcus neoformans virulence gene discovery through insertional mutagenesis. Eukaryotic cell 2004. PMID: 15075272


  32. de Jesús-Berríos M, Liu L, Nussbaum JC, Cox GM, Stamler JS, Heitman J. Enzymes that counteract nitrosative stress promote fungal virulence. Current biology : CB 2003. PMID: 14614821


  33. Touchman JW, Bouffard GG, Weintraub LA, Idol JR, Wang L, Robbins CM, Nussbaum JC, Lovett M, Green ED. 2006 expressed-sequence tags derived from human chromosome 7-enriched cDNA libraries. Genome research 1997. PMID: 9074931