Joseph Wong, MD

Professor In Residence

I have experience and training in general infectious diseases medicine and internal medicine with a focus on care of HIV+ patients. My research activity focuses on understanding how HIV persists in patients despite potent antiretroviral therapy and developing strategies to eliminate persistent viral reservoirs.

Education
Fellowship, 06/1994 - Infectious Diseases, UC San Diego
Residency, 06/1989 - Internal Medicine, McGaw Medical Ctr, Northwestern University
Internship, 06/1983 - Internal Medicine, U.S. Naval Hospital
M.D., 06/1982 - Medicine, Northwestern University Medical School
B.S., 06/1980 - Honors Program in Med Education, Northwestern University
Publications

  1. Kadiyala GN, Telwatte S, Wedrychowski A, Janssens J, Kim SJ, Kim P, Deeks S, Wong JK, Yukl SA. Differential susceptibility of cells infected with defective and intact HIV proviruses to killing by obatoclax and other small molecules. AIDS (London, England) 2024. PMID: 38626436


  2. Qing Sun, Jonathan Li, Hui Ren, Larry Pastor, Yulia Loginova, Roberta Madej, Kristopher Taylor, Joseph K. Wong, Zhao Zhang, Aiguo Zhang, Chuanyi M. Lu, Michael Y. Sha. Saliva as a Testing Specimen with or without Pooling for SARS-CoV-2 Detection by Multiplex RT-PCR Test. Advances in Medical Imaging, Detection, and Diagnosis 2023. PMID:


  3. Wedrychowski A, Martin HA, Li Y, Telwatte S, Kadiyala GN, Melberg M, Etemad B, Connick E, Jacobson JM, Margolis DM, Skiest D, Volberding P, Hecht F, Deeks S, Wong JK, Li JZ, Yukl SA. Transcriptomic Signatures of Human Immunodeficiency Virus Post-Treatment Control. Journal of virology 2022. PMID: 36541802


  4. Kelly JD, Leonard S, Hoggatt KJ, Boscardin WJ, Lum EN, Moss-Vazquez TA, Andino R, Wong JK, Byers A, Bravata DM, Tien PC, Keyhani S. Incidence of Severe COVID-19 Illness Following Vaccination and Booster With BNT162b2, mRNA-1273, and Ad26.COV2.S Vaccines. JAMA 2022. PMID: 36156706


  5. Moron-Lopez S, Bernal S, Wong JK, Martinez-Picado J, Yukl SA. ABX464 decreases the total HIV reservoir and HIV transcription initiation in CD4 + T cells from HIV-infected ART-suppressed individuals. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2021. PMID: 34436569


  6. Lu MD, Telwatte S, Kumar N, Ferreira F, Martin HA, Kadiyala GN, Wedrychowski A, Moron-Lopez S, Chen TH, Goecker EA, Coombs RW, Lu CM, Wong JK, Tsibris A, Yukl SA. Novel assays to investigate the mechanisms of latent infection with HIV-2. 2022. PMID: 35476802


  7. Wu G, Zuck P, Goh SL, Milush JM, Vohra P, Wong JK, Somsouk M, Yukl SA, Shacklett BL, Chomont N, Haase AT, Hatano H, Schacker TW, Deeks SG, Hazuda DJ, Hunt PW, Howell BJ. Gag p24 is a Marker of HIV Expression in Tissues and Correlates with Immune Response. The Journal of infectious diseases 2021. PMID: 33693750


  8. Moron-Lopez S, Xie G, Kim P, Siegel DA, Lee S, Wong JK, Price JC, Elnachef N, Greenblatt RM, Tien PC, Roan NR, Yukl SA. Tissue-specific differences in HIV DNA levels and mechanisms that govern HIV transcription in blood, gut, genital tract and liver in ART-treated women. Journal of the International AIDS Society 2021. PMID: 34235864


  9. Tseng ZH, Moffatt E, Kim A, Vittinghoff E, Ursell P, Connolly A, Olgin JE, Wong JK, Hsue PY. Sudden Cardiac Death and Myocardial Fibrosis, Determined by Autopsy, in Persons with HIV. The New England journal of medicine 2021. PMID: 34133860


  10. Telwatte S, Martin HA, Marczak R, Fozouni P, Vallejo-Gracia A, Kumar GR, Murray V, Lee S, Ott M, Wong JK, Yukl SA. Novel RT-ddPCR assays for measuring the levels of subgenomic and genomic SARS-CoV-2 transcripts. Methods (San Diego, Calif.) 2021. PMID: 33882362


  11. Qing Sun, Jonathan Li, Hui Ren, Larry Pastor, Yulia Loginova, Joseph Wong, Zhao Zhang, Aiguo Zhang, Chuanyi Mark Lu, Michael Sha. Abstract P21: Saliva as a testing specimen with or without pooling for SARS-CoV-2 detection by multiplex RT-PCR test. Clinical Cancer Research 2021. PMID:


  12. Telwatte S, Kumar N, Vallejo-Gracia A, Kumar GR, Lu CM, Ott M, Wong JK, Yukl SA. Novel RT-ddPCR assays for simultaneous quantification of multiple noncoding and coding regions of SARS-CoV-2 RNA. Volume 292. Journal of virological methods 2021. PMID: 33667568


  13. Sun Q, Li J, Ren H, Pastor L, Loginova Y, Madej R, Taylor K, Wong JK, Zhang Z, Zhang A, Lu CM, Sha MY. Saliva as a testing specimen with or without pooling for SARS-CoV-2 detection by multiplex RT-PCR test. PloS one 2021. PMID: 33621263


  14. Telwatte S, Kumar N, Vallejo-Gracia A, Kumar GR, Lu CM, Ott M, Wong JK, Yukl SA. Novel RT-ddPCR Assays for determining the transcriptional profile of SARS-CoV-2. bioRxiv : the preprint server for biology 2021. PMID: 33469579


  15. Moron-Lopez S, Telwatte S, Sarabia I, Battivelli E, Montano M, Macedo AB, Aran D, Butte AJ, Jones RB, Bosque A, Verdin E, Greene WC, Wong JK, Yukl SA. Human splice factors contribute to latent HIV infection in primary cell models and blood CD4+ T cells from ART-treated individuals. Volume 16 of Issue 11. PLoS pathogens 2020. PMID: 33253324


  16. Telwatte S, Kim P, Chen TH, Milush JM, Somsouk M, Deeks SG, Hunt PW, Wong JK, Yukl SA. Mechanistic differences underlying HIV latency in the gut and blood contribute to differential responses to latency-reversing agents. AIDS (London, England) 2020. PMID: 32910065


  17. S. Moron-Lopez, G. Xie, P. Kim, J. Wong, J. Price, N. Elnachef, R. Greenblatt, P. Tien, N. Roan, S. Yukl. OP 7.6 Tissue-specific differences in the mechanisms that govern HIV latency in blood, liver, gut and genital tract in ART-suppressed women. Journal of virus eradication 2019. PMID:


  18. S. Moron-Lopez, S. Bernal, J.M. Steens, J.K. Wong, J. Martinez-Picado, S.A. Yukl. OP 8.3 Intensification of ART with ABX464 decreases the total HIV reservoir and HIV transcription initiation in CD4 T cells from HIV-infected ART-suppressed individuals. Journal of virus eradication 2019. PMID:


  19. S. Telwatte, M. Montano, R. Resop, E. Battivelli, S. Morón-López, E. Verdin, W. Greene, A. Bosque, J. Wong, S. Yukl. PP 1.3 Single cell analysis reveals molecular signatures of HIV latency in primary cell models. Journal of virus eradication 2019. PMID:


  20. Telwatte S, Morón-López S, Aran D, Kim P, Hsieh C, Joshi S, Montano M, Greene WC, Butte AJ, Wong JK, Yukl SA. Heterogeneity in HIV and cellular transcription profiles in cell line models of latent and productive infection: implications for HIV latency. Retrovirology 2019. PMID: 31711503


  21. S. Telwatte, P. Kim, T.-H. Chen, J. Milush, M. Somsouk, P. Hunt, S. Deeks, J. Wong, S. Yukl. 10 Tissue-specific effects of latency-reversing agents on HIV transcriptional blocks in gut and blood. Journal of virus eradication 2019. PMID:


  22. S. Moron-Lopez, I. Sarabia, E. Battivelli, M. Montano, S. Telwatte, A. Bosque, E. Verdin, W. Greene, J.K. Wong, S.A. Yukl. 12 In-depth transcription profile comparison of multiple primary cell HIV latency models. Journal of virus eradication 2019. PMID:


  23. Jiang G, Maverakis E, Cheng MY, Elsheikh MM, Deleage C, Méndez-Lagares G, Shimoda M, Yukl SA, Hartigan-O'Connor DJ, Thompson GR, Estes JD, Wong JK, Dandekar S. Disruption of latent HIV in vivo during the clearance of actinic keratosis by ingenol mebutate. JCI insight 2019. PMID: 30944245


  24. Moron-Lopez S, Kim P, SøGaard OS, Tolstrup M, Wong JK, Yukl SA. Characterization of the HIV-1 transcription profile after romidepsin administration in ART-suppressed individuals. AIDS (London, England) 2018. PMID: 30531314


  25. . HIV POST SCD: RATES OF AUTOPSY-DEFINED SUDDEN ARRHYTHMIC DEATH AND CARDIAC FIBROSIS ARE >60% HIGHER IN PERSONS WITH HIV. 2019. PMID:


  26. Telwatte S, Lee S, Somsouk M, Hatano H, Baker C, Kaiser P, Kim P, Chen TH, Milush J, Hunt PW, Deeks SG, Wong JK, Yukl SA. Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency. PLoS pathogens 2018. PMID: 30440043


  27. Yukl SA, Kaiser P, Kim P, Telwatte S, Joshi SK, Vu M, Lampiris H, Wong JK. HIV latency in isolated patient CD4+ T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing. Science translational medicine 2018. PMID: 29491188


  28. Jiang G, Nguyen D, Archin NM, Yukl SA, Méndez-Lagares G, Tang Y, Elsheikh MM, Thompson GR, Hartigan-O'Connor DJ, Margolis DM, Wong JK, Dandekar S. HIV latency is reversed by ACSS2-driven histone crotonylation. The Journal of clinical investigation 2018. PMID: 29457784


  29. Anna Cereseto, Yuntao Wu, Jan Davidson-Moncada, Thomas S. Uldrick, Joel Palefsky, Steven A. Yukl, Joseph K. Wong, Shokouh Makvandi-Nejad, Courtney V. Fletcher, Anthony T. Podany, Andrea Calcagno, C. William Wester, Francoise Brun-Vezinet, Sophie Matheron, Diane Descamps, Sima S. Toussi, Michael Rosenberg, Harjot K. Singh, Marshall J. Glesby, Charles Muiruri, Habib R. Omar, John A. Bartlett, Camille Libre, Julien Batisse, Santiago Guerrero, Roland Marquet, Jean-Christophe Paillart, Mark Spear, Yuntao Wu, Christina Karsten, Stefan Pöhlmann, Laure Papin, Coralie F. Daussy, Jamal Alfaisal, Lucile Espert, Fabien P. Blanchet, Julià Blanco, Martine Biard-Piechaczyk. Acetylation. 2018. PMID:


  30. . Anatomic Compartments as a Barrier to HIV Cure. 2018. PMID:


  31. S. Telwatte, S. Lee, M. Somsouk, H. Hatano, C. Baker, P. Kim, T.-H. Chen, J. Milush, P. Hunt, S. Deeks, J.K. Wong, S.A. Yukl. OP4.6 Gut and blood differ in mechanisms governing HIV transcription/latency. 2017. PMID:


  32. Beliakova-Bethell N, Hezareh M, Wong JK, Strain MC, Lewinski MK, Richman DD, Spina CA. Relative efficacy of T cell stimuli as inducers of productive HIV-1 replication in latently infected CD4 lymphocytes from patients on suppressive cART. Virology 2017. PMID: 28527342


  33. Koelsch KK, Rasmussen TA, Hey-Nguyen WJ, Pearson C, Xu Y, Bailey M, Marks KH, Sasson SC, Taylor MS, Tantau R, Obeid S, Milner B, Morrissey O, Pinto AN, Suzuki K, Busch MP, Keating SM, Kaiser P, Yukl S, Wong JK, Hiener BM, Palmer S, Zaunders J, Post JJ, Chan DJ, Avery S, Milliken ST, Kelleher AD, Lewin SR, Cooper DA. Impact of Allogeneic Hematopoietic Stem Cell Transplantation on the HIV Reservoir and Immune Response in 3 HIV-Infected Individuals. Volume 75 of Issue 3. Journal of acquired immune deficiency syndromes (1999) 2017. PMID: 28350553


  34. Jiang G, Santos Rocha C, Hirao LA, Mendes EA, Tang Y, Thompson GR, Wong JK, Dandekar S. HIV Exploits Antiviral Host Innate GCN2-ATF4 Signaling for Establishing Viral Replication Early in Infection. mBio 2017. PMID: 28465428


  35. Kaiser P, Joshi SK, Kim P, Li P, Liu H, Rice AP, Wong JK, Yukl SA. Assays for precise quantification of total (including short) and elongated HIV-1 transcripts. Volume 242. Journal of virological methods 2016. PMID: 28034670


  36. Wong JK, Yukl SA. Tissue reservoirs of HIV. Volume 11 of Issue 4. Current opinion in HIV and AIDS 2016. PMID: 27259045


  37. Li P, Kaiser P, Lampiris HW, Kim P, Yukl SA, Havlir DV, Greene WC, Wong JK. Stimulating the RIG-I pathway to kill cells in the latent HIV reservoir following viral reactivation. Volume 22 of Issue 7. Nature medicine 2016. PMID: 27294875


  38. Ma Q, Vaida F, Wong J, Sanders CA, Kao YT, Croteau D, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur JC, Morgello S, Simpson DM, Heaton RK, Grant I, Letendre SL. Long-term efavirenz use is associated with worse neurocognitive functioning in HIV-infected patients. Journal of neurovirology 2015. PMID: 26407716


  39. Jiang G, Mendes EA, Kaiser P, Wong DP, Tang Y, Cai I, Fenton A, Melcher GP, Hildreth JE, Thompson GR, Wong JK, Dandekar S. Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation. Volume 11 of Issue 7. PLoS pathogens 2015. PMID: 26225771


  40. Yukl SA, Shergill AK, Girling V, Li Q, Killian M, Epling L, Li P, Kaiser P, Haase A, Havlir DV, McQuaid K, Sinclair E, Wong JK. Site-specific differences in T cell frequencies and phenotypes in the blood and gut of HIV-uninfected and ART-treated HIV+ adults. Volume 10 of Issue 3. PloS one 2015. PMID: 25811360


  41. Yu M, Wong JK, Tang C, Turner P, Todd MH, Rutledge PJ. Efficient deprotection of F-BODIPY derivatives: removal of BF2 using Brønsted acids. Beilstein journal of organic chemistry 2015. PMID: 25670990


  42. . Anatomic Compartments as a Barrier to HIV Cure. 2015. PMID:


  43. Chartier M, Crouch PC, Tullis V, Catella S, Frawley E, Filanosky C, Carmody T, McQuaid J, Lampiris H, Wong JK. The Montreal Cognitive Assessment: A Pilot Study of a Brief Screening Tool for Mild and Moderate Cognitive Impairment in HIV-Positive Veterans. Journal of the International Association of Providers of AIDS Care 2014. PMID: 25487428


  44. Abdel-Mohsen M, Deng X, Danesh A, Liegler T, Jacobs ES, Rauch A, Ledergerber B, Norris PJ, Günthard HF, Wong JK, Pillai SK. Role of microRNA modulation in the interferon-a/ribavirin suppression of HIV-1 in vivo. Volume 9 of Issue 10. PloS one 2014. PMID: 25275557


  45. Jiang G, Mendes EA, Kaiser P, Sankaran-Walters S, Tang Y, Weber MG, Melcher GP, Thompson GR, Tanuri A, Pianowski LF, Wong JK, Dandekar S. Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cd-NF-?B signaling. Volume 28 of Issue 11. AIDS (London, England) 2014. PMID: 24804860


  46. Li P, Fujimoto K, Bourguingnon L, Yukl S, Deeks S, Wong JK. Exogenous and endogenous hyaluronic acid reduces HIV infection of CD4(+) T cells. Volume 92 of Issue 9. Immunology and cell biology 2014. PMID: 24957217


  47. Liegler T, Abdel-Mohsen M, Bentley LG, Atchison R, Schmidt T, Javier J, Mehrotra M, Eden C, Glidden DV, McMahan V, Anderson PL, Li P, Wong JK, Buchbinder S, Guanira JV, Grant RM. HIV-1 drug resistance in the iPrEx preexposure prophylaxis trial. The Journal of infectious diseases 2014. PMID: 24740633


  48. Yukl SA, Kaiser P, Kim P, Li P, Wong JK. Advantages of using the QIAshredder instead of restriction digestion to prepare DNA for droplet digital PCR. Volume 56 of Issue 4. BioTechniques 2014. PMID: 24724845


  49. Dunham RM, Vujkovic-Cvijin I, Yukl SA, Broadhurst MJ, Loke P, Albright RG, Wong JK, Lederman MM, Somsouk M, Hunt PW, Martin JN, Deeks SG, McCune JM. Discordance between peripheral and colonic markers of inflammation during suppressive ART. Volume 65 of Issue 2. Journal of acquired immune deficiency syndromes (1999) 2014. PMID: 24121758


  50. Yukl SA, Sinclair E, Somsouk M, Hunt PW, Epling L, Killian M, Girling V, Li P, Havlir DV, Deeks SG, Wong JK, Hatano H. A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cells. Volume 28 of Issue 3. AIDS (London, England) 2014. PMID: 24322272


  51. Moyers BS, Secemsky EA, Vittinghoff E, Wong JK, Havlir DV, Hsue PY, Tseng ZH. Effect of left ventricular dysfunction and viral load on risk of sudden cardiac death in patients with human immunodeficiency virus. Volume 113 of Issue 7. The American journal of cardiology 2014. PMID: 24521717


  52. McDermott GP, Do D, Litterst CM, Maar D, Hindson CM, Steenblock ER, Legler TC, Jouvenot Y, Marrs SH, Bemis A, Shah P, Wong J, Wang S, Sally D, Javier L, Dinio T, Han C, Brackbill TP, Hodges SP, Ling Y, Klitgord N, Carman GJ, Berman JR, Koehler RT, Hiddessen AL, Walse P, Bousse L, Tzonev S, Hefner E, Hindson BJ, Cauly TH, Hamby K, Patel VP, Regan JF, Wyatt PW, Karlin-Neumann GA, Stumbo DP, Lowe AJ. Multiplexed target detection using DNA-binding dye chemistry in droplet digital PCR. Analytical chemistry 2013. PMID: 24180464


  53. Abdel-Mohsen M, Deng X, Liegler T, Guatelli JC, Salama MS, Ghanem Hel-D, Rauch A, Ledergerber B, Deeks SG, Günthard HF, Wong JK, Pillai SK. Effects of alpha interferon treatment on intrinsic anti-HIV-1 immunity in vivo. Volume 88 of Issue 1. Journal of virology 2013. PMID: 24155399


  54. Abdel-Mohsen M, Raposo RA, Deng X, Li M, Liegler T, Sinclair E, Salama MS, Ghanem Hel-D, Hoh R, Wong JK, David M, Nixon DF, Deeks SG, Pillai SK. Expression profile of host restriction factors in HIV-1 elite controllers. Volume 10. Retrovirology 2013. PMID: 24131498


  55. Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, Shacklett BL, Wong JK, Deeks SG. Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers. Volume 9 of Issue 10. PLoS pathogens 2013. PMID: 24130489


  56. Hatano H, Somsouk M, Sinclair E, Harvill K, Gilman L, Cohen M, Hoh R, Hunt PW, Martin JN, Wong JK, Deeks SG, Yukl SA. Comparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollers. Volume 27 of Issue 14. AIDS (London, England) 2013. PMID: 24157906


  57. Yukl SA, Shergill AK, Ho T, Killian M, Girling V, Epling L, Li P, Wong LK, Crouch P, Deeks SG, Havlir DV, McQuaid K, Sinclair E, Wong JK. The distribution of HIV DNA and RNA in cell subsets differs in gut and blood of HIV-positive patients on ART: implications for viral persistence. Volume 208 of Issue 8. The Journal of infectious diseases 2013. PMID: 23852128


  58. Yukl SA, Boritz E, Busch M, Bentsen C, Chun TW, Douek D, Eisele E, Haase A, Ho YC, Hütter G, Justement JS, Keating S, Lee TH, Li P, Murray D, Palmer S, Pilcher C, Pillai S, Price RW, Rothenberger M, Schacker T, Siliciano J, Siliciano R, Sinclair E, Strain M, Wong J, Richman D, Deeks SG. Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient. Volume 9 of Issue 5. PLoS pathogens 2013. PMID: 23671416


  59. . PROLONGED QT INTERVAL PREDICTS SUDDEN CARDIAC DEATH IN HIV-INFECTED INDIVIDUALS. 2013. PMID:


  60. Eriksson S, Graf EH, Dahl V, Strain MC, Yukl SA, Lysenko ES, Bosch RJ, Lai J, Chioma S, Emad F, Abdel-Mohsen M, Hoh R, Hecht F, Hunt P, Somsouk M, Wong J, Johnston R, Siliciano RF, Richman DD, O'Doherty U, Palmer S, Deeks SG, Siliciano JD. Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies. Volume 9 of Issue 2. PLoS pathogens 2013. PMID: 23459007


  61. Jain V, Liegler T, Kabami J, Chamie G, Clark TD, Black D, Geng EH, Kwarisiima D, Wong JK, Abdel-Mohsen M, Sonawane N, Aweeka FT, Thirumurthy H, Petersen ML, Charlebois ED, Kamya MR, Havlir DV. Assessment of population-based HIV RNA levels in a rural east African setting using a fingerprick-based blood collection method. Volume 56 of Issue 4. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012. PMID: 23243180


  62. Hightower GK, Wong JK, Letendre SL, Umlauf AA, Ellis RJ, Ignacio CC, Heaton RK, Collier AC, Marra CM, Clifford DB, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Grant I, Little SJ, Richman DD, Kosakovsky Pond SL, Smith DM. Higher HIV-1 genetic diversity is associated with AIDS and neuropsychological impairment. Virology 2012. PMID: 22999095


  63. Tseng ZH, Secemsky EA, Dowdy D, Vittinghoff E, Moyers B, Wong JK, Havlir DV, Hsue PY. Sudden cardiac death in patients with human immunodeficiency virus infection. Volume 59 of Issue 21. Journal of the American College of Cardiology 2012. PMID: 22595409


  64. Choi JY, Hightower GK, Wong JK, Heaton R, Woods S, Grant I, Marcotte TD, Ellis RJ, Letendre SL, Collier AC, Marra CM, Clifford DB, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Richman DD, Smith DM. Genetic features of cerebrospinal fluid-derived subtype B HIV-1 tat. Journal of neurovirology 2012. PMID: 22528397


  65. Pillai SK, Abdel-Mohsen M, Guatelli J, Skasko M, Monto A, Fujimoto K, Yukl S, Greene WC, Kovari H, Rauch A, Fellay J, Battegay M, Hirschel B, Witteck A, Bernasconi E, Ledergerber B, Günthard HF, Wong JK. Role of retroviral restriction factors in the interferon-a-mediated suppression of HIV-1 in vivo. Volume 109 of Issue 8. Proceedings of the National Academy of Sciences of the United States of America 2012. PMID: 22315404


  66. Ruel TD, Boivin MJ, Boal HE, Bangirana P, Charlebois E, Havlir DV, Rosenthal PJ, Dorsey G, Achan J, Akello C, Kamya MR, Wong JK. Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell counts. Volume 54 of Issue 7. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012. PMID: 22308272


  67. Yukl SA, Li P, Fujimoto K, Lampiris H, Lu CM, Hare CB, Deeks SG, Liegler T, Pandori M, Havlir DV, Wong JK. Modification of the Abbott RealTime assay for detection of HIV-1 plasma RNA viral loads less than one copy per milliliter. Volume 175 of Issue 2. Journal of virological methods 2011. PMID: 21536073


  68. Lerner P, Guadalupe M, Donovan R, Hung J, Flamm J, Prindiville T, Sankaran-Walters S, Syvanen M, Wong JK, George MD, Dandekar S. The gut mucosal viral reservoir in HIV-infected patients is not the major source of rebound plasma viremia following interruption of highly active antiretroviral therapy. Journal of virology 2011. PMID: 21345945


  69. Ruel TD, Kamya MR, Li P, Pasutti W, Charlebois ED, Liegler T, Dorsey G, Rosenthal PJ, Havlir DV, Wong JK, Achan J. Early virologic failure and the development of antiretroviral drug resistance mutations in HIV-infected Ugandan children. Volume 56 of Issue 1. Journal of acquired immune deficiency syndromes (1999) 2011. PMID: 21099693


  70. Heaton RK, Franklin DR, Ellis RJ, McCutchan JA, Letendre SL, Leblanc S, Corkran SH, Duarte NA, Clifford DB, Woods SP, Collier AC, Marra CM, Morgello S, Mindt MR, Taylor MJ, Marcotte TD, Atkinson JH, Wolfson T, Gelman BB, McArthur JC, Simpson DM, Abramson I, Gamst A, Fennema-Notestine C, Jernigan TL, Wong J, Grant I. HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. Journal of neurovirology 2010. PMID: 21174240


  71. Heaton RK, Clifford DB, Franklin DR, Woods SP, Ake C, Vaida F, Ellis RJ, Letendre SL, Marcotte TD, Atkinson JH, Rivera-Mindt M, Vigil OR, Taylor MJ, Collier AC, Marra CM, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Abramson I, Gamst A, Fennema-Notestine C, Jernigan TL, Wong J, Grant I. HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology 2010. PMID: 21135382


  72. . CD4+ T cell reconstitution, T cell activation, and memory T cell subset composition in blood and gut of HIV-negative and ART-suppressed HIV-positive patients: implications for HIV persistence in the gut. 2010. PMID:


  73. Yukl SA, Shergill AK, McQuaid K, Gianella S, Lampiris H, Hare CB, Pandori M, Sinclair E, Günthard HF, Fischer M, Wong JK, Havlir DV. Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy. Volume 24 of Issue 16. AIDS (London, England) 2010. PMID: 20827162


  74. Yukl SA, Gianella S, Sinclair E, Epling L, Li Q, Duan L, Choi AL, Girling V, Ho T, Li P, Fujimoto K, Lampiris H, Hare CB, Pandori M, Haase AT, Günthard HF, Fischer M, Shergill AK, McQuaid K, Havlir DV, Wong JK. Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy. Volume 202 of Issue 10. The Journal of infectious diseases 2010. PMID: 20939732


  75. Li P, Ruel T, Fujimoto K, Hatano H, Yukl S, Eller LA, Liegler T, Kamya M, Gassasira A, Dorsey G, Rosenthal PJ, Havlir DV, Wong JK. Novel application of Locked Nucleic Acid chemistry for a Taqman assay for measuring diverse human immunodeficiency virus type 1 subtypes. Volume 170 of Issue 1-2. Journal of virological methods 2010. PMID: 20863855


  76. Boivin MJ, Ruel TD, Boal HE, Bangirana P, Cao H, Eller LA, Charlebois E, Havlir DV, Kamya MR, Achan J, Akello C, Wong JK. HIV-subtype A is associated with poorer neuropsychological performance compared with subtype D in antiretroviral therapy-naive Ugandan children. AIDS (London, England) 2010. PMID: 20425886


  77. Robertson K, Liner J, Hakim J, Sankalé JL, Grant I, Letendre S, Clifford D, Diop AG, Jaye A, Kanmogne G, Njamnshi A, Langford TD, Weyessa TG, Wood C, Banda M, Hosseinipour M, Sacktor N, Nakasuja N, Bangirana P, Paul R, Joska J, Wong J, Boivin M, Holding P, Kammerer B, Van Rie A, Ive P, Nath A, Lawler K, Adebamowo C, Royal W, Joseph J. NeuroAIDS in Africa. Journal of neurovirology 2010. PMID: 20500018


  78. Wong JK, Strain MC, Porrata R, Reay E, Sankaran-Walters S, Ignacio CC, Russell T, Pillai SK, Looney DJ, Dandekar S. In vivo CD8+ T-cell suppression of siv viremia is not mediated by CTL clearance of productively infected cells. Volume 6 of Issue 1. PLoS pathogens 2010. PMID: 20126442


  79. Joos B, Rieder P, Fischer M, Kuster H, Rusert P, Trkola A, Pillai SK, Wong JK, Weber R, Günthard HF. Association between specific HIV-1 Env traits and virologic control in vivo. Volume 10 of Issue 3. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2009. PMID: 19524069


  80. Ruel T, Ssewanyana I, Achan J, Gasasira A, Kamya MR, Kekitiinwa A, Wong JK, Cao H, Havlir D, Charlebois ED. Dynamics of T cell activation accompanying CD4 recovery in antiretroviral treated HIV-infected Ugandan children. Clinical immunology (Orlando, Fla.) 2009. PMID: 19303366


  81. Yukl S, Pillai S, Li P, Chang K, Pasutti W, Ahlgren C, Havlir D, Strain M, Günthard H, Richman D, Rice AP, Daar E, Little S, Wong JK. Latently-infected CD4+ T cells are enriched for HIV-1 Tat variants with impaired transactivation activity. Volume 387 of Issue 1. Virology 2009. PMID: 19268337


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  92. Koelsch KK, Liu L, Haubrich R, May S, Havlir D, Günthard HF, Ignacio CC, Campos-Soto P, Little SJ, Shafer R, Robbins GK, D'Aquila RT, Kawano Y, Young K, Dao P, Spina CA, Richman DD, Wong JK. Dynamics of total, linear nonintegrated, and integrated HIV-1 DNA in vivo and in vitro. The Journal of infectious diseases 2008. PMID: 18248304


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  97. Pillai SK, Pond SL, Liu Y, Good BM, Strain MC, Ellis RJ, Letendre S, Smith DM, Günthard HF, Grant I, Marcotte TD, McCutchan JA, Richman DD, Wong JK. Genetic attributes of cerebrospinal fluid-derived HIV-1 env. Volume 129 of Issue Pt 7. Brain : a journal of neurology 2006. PMID: 16735456


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  100. Strain MC, Little SJ, Daar ES, Havlir DV, Gunthard HF, Lam RY, Daly OA, Nguyen J, Ignacio CC, Spina CA, Richman DD, Wong JK. Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1. The Journal of infectious diseases 2005. PMID: 15809898


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  109. Havlir DV, Strain MC, Clerici M, Ignacio C, Trabattoni D, Ferrante P, Wong JK. Productive infection maintains a dynamic steady state of residual viremia in human immunodeficiency virus type 1-infected persons treated with suppressive antiretroviral therapy for five years. Journal of virology 2003. PMID: 14512569


  110. Koelsch KK, Smith DM, Little SJ, Ignacio CC, Macaranas TR, Brown AJ, Petropoulos CJ, Richman DD, Wong JK. Clade B HIV-1 superinfection with wild-type virus after primary infection with drug-resistant clade B virus. AIDS (London, England) 2003. PMID: 12700477


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