Kelly Wentworth, MD

Asst Professor in Residence

My research focuses on understanding the role of Gs-protein coupled receptor signaling in skeletal development, with a focused interest in craniofacial fibrous dysplasia of the bone (FD) and McCune-Albright syndrome (MAS).

Education
2019 - non-ACGME Endocrinology Research Fellowship, University of California
2017 - Fellowship- Diabetes, Endocrinology and Metabolism, University of California
2011 - Residency-Internal Medicine, University of Washington
MD, 2008 - Medicine, University of Connecticut School of Medicine
BA, 2003 - Biology, University of Rochester
Publications

  1. Lounev V, Groppe JC, Brewer N, Wentworth KL, Smith V, Xu M, Schomburg L, Bhargava P, Al Mukaddam M, Hsiao EC, Shore EM, Pignolo RJ, Kaplan FS. MMP-9 deficiency confers resilience in Fibrodysplasia Ossificans Progressiva in a man and mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2024. PMID: 38477818


  2. Atomwise AIMS Program. AI is a viable alternative to high throughput screening: a 318-target study. Scientific Reports 2024. PMID: 38565852


  3. Lung H, Wentworth KL, Moody T, Zamarioli A, Ram A, Ganesh G, Kang M, Ho S, Hsiao EC. Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone. JBMR plus 2024. PMID: 38577521


  4. Pasieka JL, Wentworth K, Yeo CT, Cremers S, Dempster D, Fukumoto S, Goswami R, Houillier P, Levine MA, Pasternak JD, Perrier ND, Sitges-Serra A, Shoback DM. Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022. PMID: 36153665


  5. Wentworth KL, Lalonde RL, Groppe JC, Brewer N, Moody T, Hansberry S, Taylor K, Shore EM, Kaplan FS, Pignolo RJ, Yelick PC, Hsiao EC. Functional testing of BMP pathway variants identified on whole exome sequencing in a patient with delayed-onset fibrodysplasia ossificans progressiva (FOP) using ACVR1R206H -specific human cellular and zebrafish models. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022. PMID: 36153796


  6. Singh S, Morshed S, Motamedi D, Kidane J, Paul A, Hsiao EC, Wentworth KL. Identification of Risk Factors in the Development of Heterotopic Ossification after Primary Total Hip Arthroplasty. 2022. PMID: 35451005


  7. Yu X, Ton AN, Niu Z, Morales BM, Chen J, Braz J, Lai MH, Barruet E, Liu H, Cheung K, Ali S, Chan T, Bigay K, Ho J, Nikolli I, Hansberry S, Wentworth K, Kriegstein A, Basbaum A, Hsiao EC. An ACVR1 activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans. 2022. PMID: 35442931


  8. Kou S, Kile S, Kambampati SS, Brady EC, Wallace H, De Sousa CM, Cheung K, Dickey L, Wentworth KL, Hsiao EC. Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva. 2022. PMID: 35246171


  9. Kou S, De Cunto C, Baujat G, Wentworth KL, Grogan DR, Brown MA, Di Rocco M, Keen R, Al Mukaddam M, le Quan Sang KH, Masharani U, Kaplan FS, Pignolo RJ, Hsiao EC. Patients with ACVR1R206H mutations have an increased prevalence of cardiac conduction abnormalities on electrocardiogram in a natural history study of Fibrodysplasia Ossificans Progressiva. Orphanet journal of rare diseases 2020. PMID: 32727600


  10. Singh S, Kidane J, Wentworth KL, Motamedi D, Morshed S, Schober AE, Hsiao EC. Surgical management of bilateral hip fractures in a patient with fibrodysplasia ossificans progressiva treated with the RAR-? agonist palovarotene: a case report. BMC musculoskeletal disorders 2020. PMID: 32245464


  11. Lung H, Hsiao EC, Wentworth KL. Advances in Models of Fibrous Dysplasia/McCune-Albright Syndrome. Frontiers in endocrinology 2020. PMID: 32038487


  12. Cheng C, Wentworth K, Shoback DM. New Frontiers in Osteoporosis Therapy. Annual review of medicine 2019. PMID: 31509477


  13. Wentworth K, Shoback D. Applying the Guidelines for Primary Hyperparathyroidism: The Path Not Taken. JAMA internal medicine 2019. PMID: 31305872


  14. Wentworth KL, Masharani U, Hsiao EC. Therapeutic advances for blocking heterotopic ossification in fibrodysplasia ossificans progressiva. British journal of clinical pharmacology 2018. PMID: 30501012


  15. Barruet E, Morales BM, Cain CJ, Ton AN, Wentworth KL, Chan TV, Moody TA, Haks MC, Ottenhoff TH, Hellman J, Nakamura MC, Hsiao EC. NF-?B/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification. JCI insight 2018. PMID: 30429363


  16. Wentworth KL, Bigay K, Chan TV, Ho JP, Morales BM, Connor J, Brooks E, Shahriar Salamat M, Sanchez HC, Wool G, Pignolo RJ, Kaplan FS, Hsiao EC. Clinical-pathological correlations in three patients with fibrodysplasia ossificans progressiva. Bone 2017. PMID: 29033382


  17. Wentworth K, Hsing A, Urrutia A, Zhu Y, Horvai AE, Bastepe M, Hsiao EC. A Novel T55A Variant of Gs a Associated with Impaired cAMP Production, Bone Fragility, and Osteolysis. Case reports in endocrinology 2016. PMID: 27579188


  18. Sparks R, Salskov AH, Chang AS, Wentworth KL, Gupta PP, Staiger TO, Anawalt BD. Pocket change: a simple educational intervention increases hospitalist documentation of comorbidities and improves hospital quality performance measures. Volume 24 of Issue 2. Quality management in health care 2015. PMID: 25830615


  19. Mookherjee S, Narayanan M, Uchiyama T, Wentworth KL. Three hospital admissions in 9 days to diagnose azathioprine hypersensitivity in a patient with Crohn's disease. Volume 22 of Issue 2. American journal of therapeutics 2015. PMID: 23782763


  20. Mookherjee S, Monash B, Wentworth KL, Sharpe BA. Faculty development for hospitalists: structured peer observation of teaching. Journal of hospital medicine 2014. PMID: 24446215