Mark Jacobson, MD

Professor of Medicine, Emeritu

Dr. Jacobson is a clinician, educator, and researcher who specialized in HIV/AIDS and its complications after joining the UCSF faculty in 1986. His career began with leading multicenter, interventional trials that focused on developing effective treatments for AIDS-associated opportunistic infections. His subsequent research was translational, investigating protective immunity against chronic viral infections, in particular cytomegalovirus (CMV), HIV, and human papillomavirus (HPV). He taught medicine residents and medical students and provided clinical care in the Ward 86 HIV clinic at San Francisco General Hospital until March, 2020, when he moved to the Occupational Medicine division to become the infectious diseases consultant for a team of MDs, NPs and RNs who created a system to manage employee COVID-19 health issues for health care personnel working at SF General and affiliated SF Department of Public Health facilities. This included a Occupational Health Service COVID-19 Hotline and Hotline staff standard work guidance for testing/off-return to work decisions, vaccination, and management of COVID-19 vaccine adverse events. Dr. Jacobson initiated a quality improvement program that analyzes data collected by the Hotline to address questions regarding optimal employee management policies. His QI efforts have resulted in 4 medical journal publications to date. He continues to teach Hotline staff and Occupational Medicine residents, consult with Occupational Medicine leadership re policy changes and special issues that arise, and mentor junior faculty conducting observational studies of COVID-19 in health care personnel. Dr. Jacobson is also the author of Sensing Light, a novel published in 2016 about the unfolding of the AIDS epidemic in 1980s San Francisco from the perspective of front-line, treating physicians (see http://markajacobsonauthor.com/).

Education
Fellowship, 1986 - Infectious Diseases, University of California, Los Angeles
Internship/Residency, 1984 - Medicine, Kaiser Foundation Hospital, Oakland, CA
M.D., 1981 - Medicine, University of California, San Francisco
Honors and Awards
  • AIDS Research Institute Sarlo Award for Teaching Excellence, UCSF, 2013
  • Positive Health Program Teaching Award, UCSF, 2007
Websites
Publications

  1. Jacobson MA, Blanc PD, Tulsky J, Tilly M, Meister R, Huen W, McNicholas JE. Risk of subsequent SARS-CoV-2 infection among vaccinated employees with or without hybrid immunity acquired early in the Omicron-predominant era of the COVID-19 pandemic. American journal of industrial medicine 2024. PMID: 38316635


  2. Jacobson M, Hart C, Huen W, Suarez Guardado G, Villanueva A, Whitman J, Blanc PD. A Rapid Nucleic-Acid-Amplification-Test-Based, Conditional-Release-to-Work Policy for Health Care Personnel with Symptoms Consistent with COVID-19. Journal of occupational and environmental medicine 2022. PMID: 36240750


  3. Jacobson MA, Zakaria A, Maung Z, Hart C, McCalmont T, Fassett M, Amerson E. Incidence and Characteristics of Delayed Injection Site Reaction to the mRNA-1273 SARS-CoV2 Vaccine (Moderna) in a Cohort of Hospital Employees. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2021. PMID: 34086881


  4. Maung Z, Kristensen M, Hoffman B, Jacobson MA. Temperature Screening of Healthcare Personnel is Ineffective in Controlling COVID-19. 2022. PMID: 35166255


  5. Presti RM, Handley SA, Droit L, Ghannoum M, Jacobson M, Shiboski CH, Webster-Cyriaque J, Brown T, Yin MT, Overton ET. Alterations in the oral microbiome in HIV-infected participants after antiretroviral therapy administration are influenced by immune status. AIDS (London, England) 2018. PMID: 29851662


  6. Shiboski CH, Lee A, Chen H, Webster-Cyriaque J, Seaman T, Landovitz RJ, John M, Reilly N, Naini L, Palefsky J, Jacobson MA. Human papillomavirus infection in the oral cavity of HIV patients is not reduced by initiating antiretroviral therapy. AIDS (London, England) 2016. PMID: 26919735


  7. Weinberg A, Bosch R, Bennett K, Tovar-Salazar A, Benson CA, Collier AC, Zolopa A, Gulick RM, Wohl D, Polsky B, Erice A, Jacobson MA. Regulatory T cells and the risk of CMV end-organ disease in patients with AIDS. Journal of acquired immune deficiency syndromes (1999) 2014. PMID: 24378728


  8. Wohl DA, Kendall MA, Feinberg J, Alston-Smith B, Owens S, Chafey S, Marco M, Maxwell S, Benson C, Keiser P, van der Horst C, Jacobson MA. The clinical impact of continuing to prescribe antiretroviral therapy in patients with advanced AIDS who manifest no virologic or immunologic benefit. PloS one 2013. PMID: 24260125


  9. Meyer AC, Jacobson M. Asymptomatic cryptococcemia in resource-limited settings. Current HIV/AIDS reports 2013. PMID: 23715897


  10. Jacobson M, Lurain N, Hunt P. Cytomegalovirus viraemia in the modern antiretroviral era(*). Volume 12 of Issue 7. HIV medicine 2011. PMID: 21729228


  11. Hunt PW, Martin JN, Sinclair E, Epling L, Teague J, Jacobson MA, Tracy RP, Corey L, Deeks SG. Valganciclovir reduces T cell activation in HIV-infected individuals with incomplete CD4+ T cell recovery on antiretroviral therapy. Volume 203 of Issue 10. The Journal of infectious diseases 2011. PMID: 21502083


  12. Hartigan-O'Connor DJ, Jacobson MA, Tan QX, Sinclair E. Development of cytomegalovirus (CMV) immune recovery uveitis is associated with Th17 cell depletion and poor systemic CMV-specific T cell responses. Volume 52 of Issue 3. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2010. PMID: 21189271


  13. Jagannathan P, Davis E, Jacobson M, Huang L. Life-threatening immune reconstitution inflammatory syndrome after Pneumocystis pneumonia: a cautionary case series. AIDS (London, England) 2009. PMID: 19684486


  14. Wohl DA, Kendall MA, Andersen J, Crumpacker C, Spector SA, Feinberg J, Alston-Smith B, Owens S, Chafey S, Marco M, Maxwell S, Lurain N, Jabs D, Benson C, Keiser P, Jacobson MA. Low rate of CMV end-organ disease in HIV-infected patients despite low CD4+ cell counts and CMV viremia: results of ACTG protocol A5030. HIV clinical trials 2009. PMID: 19632953


  15. Jacobson MA, Ditmer DP, Sinclair E, Martin JN, Deeks SG, Hunt P, Mocarski ES, Shiboski C. Human herpesvirus replication and abnormal CD8+ T cell activation and low CD4+ T cell counts in antiretroviral-suppressed HIV-infected patients. Volume 4 of Issue 4. PloS one 2009. PMID: 19381272


  16. Jacobson MA, Adler SP, Sinclair E, Black D, Smith A, Chu A, Moss RB, Wloch MK. A CMV DNA vaccine primes for memory immune responses to live-attenuated CMV (Towne strain). Volume 27 of Issue 10. Vaccine 2009. PMID: 19168107


  17. Graber CJ, Jacobson MA, Perdreau-Remington F, Chambers HF, Diep BA. Recurrence of skin and soft tissue infection caused by methicillin-resistant Staphylococcus aureus in a HIV primary care clinic. Volume 49 of Issue 2. Journal of acquired immune deficiency syndromes (1999) 2008. PMID: 18820536


  18. Jacobson MA, Tan QX, Girling V, Poon C, Van Natta M, Jabs DA, Inokuma M, Maecker HT, Bredt B, Sinclair E. Poor predictive value of cytomegalovirus (CMV)-specific T cell assays for the development of CMV retinitis in patients with AIDS. Volume 46 of Issue 3. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008. PMID: 18173357


  19. Jacobson MA. Do CD4+ T cell functional responses to Epstein-Barr virus provide protective immunity against CNS lymphoma in AIDS? PLoS medicine 2007. PMID: 17388670


  20. Sinclair E, Tan QX, Sharp M, Girling V, Poon C, Natta MV, Jabs DA, Inokuma M, Maecker HT, Bredt B, Jacobson MA. Protective immunity to cytomegalovirus (CMV) retinitis in AIDS is associated with CMV-specific T cells that express interferon- gamma and interleukin-2 and have a CD8+ cell early maturational phenotype. Volume 194 of Issue 11. The Journal of infectious diseases 2006. PMID: 17083038


  21. Jacobson MA, Sinclair E, Bredt B, Agrillo L, Black D, Epling CL, Carvidi A, Ho T, Bains R, Girling V, Adler SP. Safety and immunogenicity of Towne cytomegalovirus vaccine with or without adjuvant recombinant interleukin-12. Volume 24 of Issue 25. Vaccine 2006. PMID: 16701925


  22. Jacobson MA, Sinclair E, Bredt B, Agrillo L, Black D, Epling CL, Carvidi A, Ho T, Bains R, Adler SP. Antigen-specific T cell responses induced by Towne cytomegalovirus (CMV) vaccine in CMV-seronegative vaccine recipients. Volume 35 of Issue 3. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2006. PMID: 16387547


  23. Jacobson MA, Nicolau DP, Sutherland C, Smith A, Aweeka F. Pharmacokinetics of clarithromycin extended-release (ER) tablets in patients with AIDS. HIV clinical trials 2005. PMID: 16306031


  24. Jabs DA, Holbrook JT, Van Natta ML, Clark R, Jacobson MA, Kempen JH, Murphy RL. Risk factors for mortality in patients with AIDS in the era of highly active antiretroviral therapy. Ophthalmology 2005. PMID: 15878056


  25. Wohl DA, Kendall MA, Owens S, Holland G, Nokta M, Spector SA, Schrier R, Fiscus S, Davis M, Jacobson MA, Currier JS, Squires K, Alston-Smith B, Andersen J, Freeman WR, Higgins M, Torriani FJ. The safety of discontinuation of maintenance therapy for cytomegalovirus (CMV) retinitis and incidence of immune recovery uveitis following potent antiretroviral therapy. HIV clinical trials 2005. PMID: 16192248


  26. Jacobson MA. Editorial comment: failure of HAART to reconstitute CMV-specific protective immunity. The AIDS reader 2005. PMID: 15844239


  27. D'Amico R, Yang Y, Mildvan D, Evans SR, Schnizlein-Bick CT, Hafner R, Webb N, Basar M, Zackin R, Jacobson MA. Lower CD4+ T lymphocyte nadirs may indicate limited immune reconstitution in HIV-1 infected individuals on potent antiretroviral therapy: analysis of immunophenotypic marker results of AACTG 5067. Journal of clinical immunology 2005. PMID: 15821887


  28. Winter HR, Trapnell CB, Slattery JT, Jacobson M, Greenspan DL, Hooton TM, Unadkat JD. The effect of clarithromycin, fluconazole, and rifabutin on sulfamethoxazole hydroxylamine formation in individuals with human immunodeficiency virus infection (AACTG 283). Clinical pharmacology and therapeutics 2004. PMID: 15470330


  29. Shacklett BL, Cox CA, Quigley MF, Kreis C, Stollman NH, Jacobson MA, Andersson J, Sandberg JK, Nixon DF. Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: implications for immune control of HIV-1 infection. Journal of immunology (Baltimore, Md. : 1950) 2004. PMID: 15210827


  30. Jacobson MA, Maecker HT, Orr PL, D'Amico R, Van Natta M, Li XD, Pollard RB, Bredt BM. Results of a cytomegalovirus (CMV)-specific CD8+/interferon- gamma+ cytokine flow cytometry assay correlate with clinical evidence of protective immunity in patients with AIDS with CMV retinitis. The Journal of infectious diseases 2004. PMID: 15073672


  31. Marshall BC, Jacobson MA, Adler SP. Avidity of antibodies to cytomegalovirus in HIV-seropositive patients with and without CMV retinitis. Viral immunology 2004. PMID: 15018666


  32. Sinclair E, Black D, Epling CL, Carvidi A, Josefowicz SZ, Bredt BM, Jacobson MA. CMV antigen-specific CD4+ and CD8+ T cell IFNgamma expression and proliferation responses in healthy CMV-seropositive individuals. Volume 17 of Issue 3. Viral immunology 2004. PMID: 15357911


  33. Jacobson JM, Lederman MM, Spritzler J, Valdez H, Tebas P, Skowron G, Wang R, Jackson JB, Fox L, Landay A, Gilbert MJ, O'Neil D, Bancroft L, Al-Harthi L, Jacobson MA, Merigan TC, Glesby MJ. Granulocyte-macrophage colony-stimulating factor induces modest increases in plasma human immunodeficiency virus (HIV) type 1 RNA levels and CD4+ lymphocyte counts in patients with uncontrolled HIV infection. The Journal of infectious diseases 2003. PMID: 14673758


  34. Shacklett BL, Cox CA, Sandberg JK, Stollman NH, Jacobson MA, Nixon DF. Trafficking of human immunodeficiency virus type 1-specific CD8+ T cells to gut-associated lymphoid tissue during chronic infection. Journal of virology 2003. PMID: 12719554


  35. Jacobson MA, Liu L, Khayam-Bashi H, Deeks SG, Hecht FM, Kahn J. Absolute or total lymphocyte count as a marker for the CD4 T lymphocyte criterion for initiating antiretroviral therapy. AIDS (London, England) 2003. PMID: 12660541


  36. Jacobson MA, Khayam-Bashi H, Martin JN, Black D, Ng V. Effect of long-term highly active antiretroviral therapy in restoring HIV-induced abnormal B-lymphocyte function. Journal of acquired immune deficiency syndromes (1999) 2002. PMID: 12473834


  37. Jacobson MA, Bredt BM. Association of cytomegalovirus (CMV)-specific CD4+ T lymphocyte reactivity and protective immunity against acquired immunodeficiency syndrome-related CMV retinitis. The Journal of infectious diseases 2002. PMID: 12447752


  38. Lalezari JP, Aberg JA, Wang LH, Wire MB, Miner R, Snowden W, Talarico CL, Shaw S, Jacobson MA, Drew WL. Phase I dose escalation trial evaluating the pharmacokinetics, anti-human cytomegalovirus (HCMV) activity, and safety of 1263W94 in human immunodeficiency virus-infected men with asymptomatic HCMV shedding. Antimicrobial agents and chemotherapy 2002. PMID: 12183255


  39. Nokta MA, Holland F, De Gruttola V, Emery VC, Jacobson MA, Griffiths P, Pollard RB, Feinberg JE. Cytomegalovirus (CMV) polymerase chain reaction profiles in individuals with advanced human immunodeficiency virus infection: relationship to CMV disease. The Journal of infectious diseases 2002. PMID: 12085316


  40. Jacobson MA, Spritzler J, Landay A, Chan E, Katzenstein D, Schock B, Fox L, Roe J, Kundu S, Pollard R. A Phase I, placebo-controlled trial of multi-dose recombinant human interleukin-12 in patients with HIV infection. AIDS (London, England) 2002. PMID: 12004273


  41. Aberg JA, Wong MK, Flamm R, Notario GF, Jacobson MA. Presence of macrolide resistance in respiratory flora of HIV-Infected patients receiving either clarithromycin or azithromycin for Mycobacterium avium complex prophylaxis. HIV clinical trials 2001. PMID: 11742432


  42. Jacobson MA, Schrier R, McCune JM, Torriani FJ, Holland GN, O'Donnell JJ, Freeman WR, Bredt BM. Cytomegalovirus (CMV)-specific CD4+ T lymphocyte immune function in long-term survivors of AIDS-related CMV end-organ disease who are receiving potent antiretroviral therapy. The Journal of infectious diseases 2001. PMID: 11294673


  43. Chin-Hong PV, Sutton DA, Roemer M, Jacobson MA, Aberg JA. Invasive fungal sinusitis and meningitis due to Arthrographis kalrae in a patient with AIDS. Journal of clinical microbiology 2001. PMID: 11158158


  44. Angel JB, Jacobson MA, Skolnik PR, Giordano M, Shapiro L, LeBeaut A, Greaves W, Fuchs AC. A multicenter, randomized, double-blind, placebo-controlled trial of recombinant human interleukin-10 in HIV-infected subjects. AIDS (London, England) 2000. PMID: 11101061


  45. Jacobson MA, Hardy D, Connick E, Watson J, DeBruin M. Phase 1 trial of a single dose of recombinant human interleukin-12 in human immunodeficiency virus-infected patients with 100-500 CD4 cells/microL. The Journal of infectious diseases 2000. PMID: 10979901


  46. Jacobson MA, Stanley H, Holtzer C, Margolis TP, Cunningham ET. Natural history and outcome of new AIDS-related cytomegalovirus retinitis diagnosed in the era of highly active antiretroviral therapy. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2000. PMID: 10619774


  47. Aweeka FT, Jacobson MA, Martin-Munley S, Hedman A, Schoenfeld P, Omachi R, Tsunoda S, Gambertoglio JG. Effect of renal disease and hemodialysis on foscarnet pharmacokinetics and dosing recommendations. Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1999. PMID: 10096579


  48. Jacobson MA. Editorial comment: when to discontinue maintenance therapy for OIs in patients on HAART. The AIDS reader 1999. PMID: 12728895


  49. Jacobson MA, Wilson S, Stanley H, Holtzer C, Cherrington J, Safrin S. Phase I study of combination therapy with intravenous cidofovir and oral ganciclovir for cytomegalovirus retinitis in patients with AIDS. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1999. PMID: 10194072


  50. Robles R, Lugo D, Gee L, Jacobson MA. Effect of antiviral drugs used to treat cytomegalovirus end-organ disease on subsequent course of previously diagnosed Kaposi's sarcoma in patients with AIDS. Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1999. PMID: 9928727


  51. Aberg JA, Yajko DM, Jacobson MA. Eradication of AIDS-related disseminated mycobacterium avium complex infection after 12 months of antimycobacterial therapy combined with highly active antiretroviral therapy. The Journal of infectious diseases 1998. PMID: 9780266


  52. Gambertoglio J, Kumar P, Dieterich D, Jacobson MA. Absence of effect of glutamic acid hydrochloride on the bioavailability of oral ganciclovir in AIDS patients with cytomegalovirus disease. Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1998. PMID: 9704949


  53. Komanduri KV, Viswanathan MN, Wieder ED, Schmidt DK, Bredt BM, Jacobson MA, McCune JM. Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1. Nature medicine 1998. PMID: 9701250


  54. Whitley RJ, Jacobson MA, Friedberg DN, Holland GN, Jabs DA, Dieterich DT, Hardy WD, Polis MA, Deutsch TA, Feinberg J, Spector SA, Walmsley S, Drew WL, Powderly WG, Griffiths PD, Benson CA, Kessler HA. Guidelines for the treatment of cytomegalovirus diseases in patients with AIDS in the era of potent antiretroviral therapy: recommendations of an international panel. International AIDS Society-USA. Archives of internal medicine 1998. PMID: 9588429


  55. Jacobson MA. AIDS-related cytomegalovirus retinitis. Drugs of today (Barcelona, Spain : 1998) 1998. PMID: 15010704


  56. Zegans ME, Walton RC, Holland GN, O'Donnell JJ, Jacobson MA, Margolis TP. Transient vitreous inflammatory reactions associated with combination antiretroviral therapy in patients with AIDS and cytomegalovirus retinitis. American journal of ophthalmology 1998. PMID: 9512145


  57. Feinberg JE, Hurwitz S, Cooper D, Sattler FR, MacGregor RR, Powderly W, Holland GN, Griffiths PD, Pollard RB, Youle M, Gill MJ, Holland FJ, Power ME, Owens S, Coakley D, Fry J, Jacobson MA. A randomized, double-blind trial of valaciclovir prophylaxis for cytomegalovirus disease in patients with advanced human immunodeficiency virus infection. AIDS Clinical Trials Group Protocol 204/Glaxo Wellcome 123-014 International CMV Prophylaxis Study G The Journal of infectious diseases 1998. PMID: 9419169


  58. Jacobson MA, French M. Altered natural history of AIDS-related opportunistic infections in the era of potent combination antiretroviral therapy. AIDS (London, England) 1998. PMID: 9632998


  59. Kuritzkes DR, Parenti D, Ward DJ, Rachlis A, Wong RJ, Mallon KP, Rich WJ, Jacobson MA. Filgrastim prevents severe neutropenia and reduces infective morbidity in patients with advanced HIV infection: results of a randomized, multicenter, controlled trial. G-CSF 930101 Study Group. AIDS (London, England) 1998. PMID: 9456256


  60. Jacobson MA. Ganciclovir therapy for severe cytomegalovirus infection in immunocompetent patients. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1997. PMID: 9431412


  61. Fredricks DN, Rojanasthien N, Jacobson MA. AIDS-related disseminated histoplasmosis in San Francisco, California. The Western journal of medicine 1997. PMID: 9392979


  62. Jacobson MA, Liu RC, Davies D, Cohen PT. Human immunodeficiency virus disease-related neutropenia and the risk of hospitalization for bacterial infection. Archives of internal medicine 1997. PMID: 9290541


  63. Holtzer CD, Stanley HD, Jacobson MA. Severe reversible thrombocytopenia caused by recombinant human granulocyte colony-stimulating factor in an AIDS patient receiving chronic ganciclovir therapy. AIDS (London, England) 1997. PMID: 9302457


  64. Jacobson MA. Treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome. The New England journal of medicine 1997. PMID: 9211681


  65. Jacobson MA, Zegans M, Pavan PR, O'Donnell JJ, Sattler F, Rao N, Owens S, Pollard R. Cytomegalovirus retinitis after initiation of highly active antiretroviral therapy. Lancet (London, England) 1997. PMID: 9164318


  66. Mueller AJ, Jacobson MA, Hurwitz S, Chuang EL, Friedberg DN, Haidt SJ, Heinemann MH, Jabs DA, Kaplan HJ, Freeman WR. Re-evaluation of time to progression of foscarnet salvage therapy for cytomegalovirus retinitis in AIDS patients clinically resistant to ganciclovir. AIDS (London, England) 1997. PMID: 9147441


  67. Kohl S, Sigaroudinia M, Charlebois ED, Jacobson MA. Interleukin-12 administered in vivo decreases human NK cell cytotoxicity and antibody-dependent cellular cytotoxicity to human immunodeficiency virus-infected cells. The Journal of infectious diseases 1996. PMID: 8896517


  68. Marra CM, Gary DW, Kuypers J, Jacobson MA. Diagnosis of neurosyphilis in patients infected with human immunodeficiency virus type 1. The Journal of infectious diseases 1996. PMID: 8655999


  69. Jacobson MA. Current management of cytomegalovirus retinitis in AIDS update on ganciclovir and foscarnet for CMV infections. Advances in experimental medicine and biology 1996. PMID: 8815712


  70. Harb GE, Mandema JW, Delahunty T, Benowitz NB, Coleman R, Sheiner LB, Jacobson MA. Population pharmacokinetics of didanosine in patients with human immunodeficiency virus infection. The Journal of infectious diseases 1996. PMID: 8537676


  71. Jacobson MA, Gundacker H, Hughes M, Fischl M, Volberding P. Zidovudine side effects as reported by black, Hispanic, and white/non-Hispanic patients with early HIV disease: combined analysis of two multicenter placebo-controlled trials. Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1996. PMID: 8528732


  72. Jacobson MA, De Gruttola V, Reddy M, Arduino JM, Strickland S, Reichman RC, Bartlett JA, Phair JP, Hirsch MS, Collier AC. The predictive value of changes in serologic and cell markers of HIV activity for subsequent clinical outcome in patients with asymptomatic HIV disease treated with zidovudine. AIDS (London, England) 1995. PMID: 7546418


  73. Spector SA, Busch DF, Follansbee S, Squires K, Lalezari JP, Jacobson MA, Connor JD, Jung D, Shadman A, Mastre B. Pharmacokinetic, safety, and antiviral profiles of oral ganciclovir in persons infected with human immunodeficiency virus: a phase I/II study. AIDS Clinical Trials Group, and Cytomegalovirus Cooperative Study Group. The Journal of infectious diseases 1995. PMID: 7769276


  74. Holland GN, Levinson RD, Jacobson MA. Dose-related difference in progression rates of cytomegalovirus retinopathy during foscarnet maintenance therapy. AIDS Clinical Trials Group Protocol 915 Team. American journal of ophthalmology 1995. PMID: 7733183


  75. Aweeka FT, Gambertoglio JG, Kramer F, van der Horst C, Polsky B, Jayewardene A, Lizak P, Emrick L, Tong W, Jacobson MA. Foscarnet and ganciclovir pharmacokinetics during concomitant or alternating maintenance therapy for AIDS-related cytomegalovirus retinitis. Clinical pharmacology and therapeutics 1995. PMID: 7712668


  76. Jacobson MA. Update (1995) on clinical trials of antiviral therapy and prophylaxis for AIDS-related cytomegalovirus disease. Scandinavian journal of infectious diseases. Supplementum 1995. PMID: 8668951


  77. Flexner C, van der Horst C, Jacobson MA, Powderly W, Duncanson F, Ganes D, Barditch-Crovo PA, Petty BG, Baron PA, Armstrong D. Relationship between plasma concentrations of 3'-deoxy-3'-fluorothymidine (alovudine) and antiretroviral activity in two concentration-controlled trials. The Journal of infectious diseases 1994. PMID: 7995977


  78. Burack JH, Hahn JA, Saint-Maurice D, Jacobson MA. Microbiology of community-acquired bacterial pneumonia in persons with and at risk for human immunodeficiency virus type 1 infection. Implications for rational empiric antibiotic therapy. Archives of internal medicine 1994. PMID: 7979856


  79. Jacobson MA. Current management of cytomegalovirus disease in patients with AIDS. AIDS research and human retroviruses 1994. PMID: 7811543


  80. Jacobson MA, Gallant J, Wang LH, Coakley D, Weller S, Gary D, Squires L, Smiley ML, Blum MR, Feinberg J. Phase I trial of valaciclovir, the L-valyl ester of acyclovir, in patients with advanced human immunodeficiency virus disease. Antimicrobial agents and chemotherapy 1994. PMID: 7979285


  81. Jacobson MA, Kramer F, Bassiakos Y, Hooton T, Polsky B, Geheb H, O'Donnell JJ, Walker JD, Korvick JA, van der Horst C. Randomized phase I trial of two different combination foscarnet and ganciclovir chronic maintenance therapy regimens for AIDS patients with cytomegalovirus retinitis: AIDS clinical Trials Group Protocol 151. The Journal of infectious diseases 1994. PMID: 8014496


  82. Jacobson MA, Polsky B, Causey D, Davis R, Tong W, O'Donnell JJ, Kuppermann BD, Heinemann MH, Feinberg J, Lizak P. Pharmacodynamic relationship of pharmacokinetic parameters of maintenance doses of foscarnet and clinical outcome of cytomegalovirus retinitis. Antimicrobial agents and chemotherapy 1994. PMID: 8067763


  83. Jacobson MA, Wulfsohn M, Feinberg JE, Davis R, Power M, Owens S, Causey D, Heath-Chiozzi ME, Murphy RL, Cheung TW. Phase II dose-ranging trial of foscarnet salvage therapy for cytomegalovirus retinitis in AIDS patients intolerant of or resistant to ganciclovir (ACTG protocol 093). AIDS Clinical Trials Group of the National Institute of Allergy and Infectious Diseases. AIDS (London, England) 1994. PMID: 8011248


  84. Stanley HD, Charlebois E, Harb G, Jacobson MA. Central venous catheter infections in AIDS patients receiving treatment for cytomegalovirus disease. Journal of acquired immune deficiency syndromes 1994. PMID: 8106966


  85. Chin DP, Hopewell PC, Yajko DM, Vittinghoff E, Horsburgh CR, Hadley WK, Stone EN, Nassos PS, Ostroff SM, Jacobson MA. Mycobacterium avium complex in the respiratory or gastrointestinal tract and the risk of M. avium complex bacteremia in patients with human immunodeficiency virus infection. The Journal of infectious diseases 1994. PMID: 7906290


  86. Jacobson MA, Besch CL, Child C, Hafner R, Matts JP, Muth K, Wentworth DN, Neaton JD, Abrams D, Rimland D. Primary prophylaxis with pyrimethamine for toxoplasmic encephalitis in patients with advanced human immunodeficiency virus disease: results of a randomized trial. Terry Beirn Community Programs for Clinical Research on AIDS. The Journal of infectious diseases 1994. PMID: 8106772


  87. Jacobson MA, Causey D, Polsky B, Hardy D, Chown M, Davis R, O'Donnell JJ, Kuppermann BD, Heinemann MH, Holland GN. A dose-ranging study of daily maintenance intravenous foscarnet therapy for cytomegalovirus retinitis in AIDS. The Journal of infectious diseases 1993. PMID: 8393058


  88. Harb GE, Alldredge BK, Coleman R, Jacobson MA. Pharmacoepidemiology of adverse drug reactions in hospitalized patients with human immunodeficiency virus disease. Journal of acquired immune deficiency syndromes 1993. PMID: 8315576


  89. Harb GE, Jacobson MA. Human immunodeficiency virus (HIV) infection. Does it increase susceptibility to adverse drug reactions? Drug safety 1993. PMID: 8347288


  90. Jacobson MA, Yajko D, Northfelt D, Charlebois E, Gary D, Brosgart C, Sanders CA, Hadley WK. Randomized, placebo-controlled trial of rifampin, ethambutol, and ciprofloxacin for AIDS patients with disseminated Mycobacterium avium complex infection. The Journal of infectious diseases 1993. PMID: 8515098


  91. Dyner TS, Lang W, Geaga J, Golub A, Stites D, Winger E, Galmarini M, Masterson J, Jacobson MA. An open-label dose-escalation trial of oral dehydroepiandrosterone tolerance and pharmacokinetics in patients with HIV disease. Journal of acquired immune deficiency syndromes 1993. PMID: 8097787


  92. Jacobson MA, Owen W, Campbell J, Brosgart C, Abrams DI. Tolerability of combined ganciclovir and didanosine for the treatment of cytomegalovirus disease associated with AIDS. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1993. PMID: 8381032


  93. Jacobson MA. Valaciclovir (BW256U87): the L-valyl ester of acyclovir. Journal of medical virology 1993. PMID: 8245883


  94. Bayard PJ, Berger TG, Jacobson MA. Drug hypersensitivity reactions and human immunodeficiency virus disease. Journal of acquired immune deficiency syndromes 1992. PMID: 1453334


  95. Reddy MM, Grieco MH, McKinley GF, Causey DM, van der Horst CM, Parenti DM, Hooton TM, Davis RB, Jacobson MA. Effect of foscarnet therapy on human immunodeficiency virus p24 antigen levels in AIDS patients with cytomegalovirus retinitis. The Journal of infectious diseases 1992. PMID: 1323624


  96. Aweeka FT, Gambertoglio JG, van der Horst C, Raasch R, Jacobson MA. Pharmacokinetics of concomitantly administered foscarnet and zidovudine for treatment of human immunodeficiency virus infection (AIDS Clinical Trials Group protocol 053). Antimicrobial agents and chemotherapy 1992. PMID: 1416864


  97. Jacobson MA, Stanley HD, Heard SE. Ganciclovir with recombinant methionyl human granulocyte colony-stimulating factor for treatment of cytomegalovirus disease in AIDS patients. AIDS (London, England) 1992. PMID: 1377475


  98. Jacobson MA. Maintenance therapy for cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome: foscarnet. The American journal of medicine 1992. PMID: 1310573


  99. Jacobson MA, Besch CL, Child C, Hafner R, Matts JP, Muth K, Wentworth DN, Deyton L. Toxicity of clindamycin as prophylaxis for AIDS-associated toxoplasmic encephalitis. Community Programs for Clinical Research on AIDS. Lancet (London, England) 1992. PMID: 1346413


  100. Bacchetti P, Moss AR, Andrews JC, Jacobson MA. Early predictors of survival in symptomatic HIV-infected persons treated with high-dose zidovudine. Journal of acquired immune deficiency syndromes 1992. PMID: 1535375


  101. Jacobson MA. Review of the toxicities of foscarnet. Journal of acquired immune deficiency syndromes 1992. PMID: 1534839


  102. Jacobson MA, Fusaro RE, Galmarini M, Lang W. Decreased serum dehydroepiandrosterone is associated with an increased progression of human immunodeficiency virus infection in men with CD4 cell counts of 200-499. The Journal of infectious diseases 1991. PMID: 1682393


  103. Jacobson MA, Hopewell PC, Yajko DM, Hadley WK, Lazarus E, Mohanty PK, Modin GW, Feigal DW, Cusick PS, Sande MA. Natural history of disseminated Mycobacterium avium complex infection in AIDS. The Journal of infectious diseases 1991. PMID: 1682396


  104. Harb GE, Bacchetti P, Jacobson MA. Survival of patients with AIDS and cytomegalovirus disease treated with ganciclovir or foscarnet. AIDS (London, England) 1991. PMID: 1663770


  105. Jacobson MA, Mills J, Rush J, Peiperl L, Seru V, Mohanty PK, Hopewell PC, Hadley WK, Broadus VC, Leoung G. Morbidity and mortality of patients with AIDS and first-episode Pneumocystis carinii pneumonia unaffected by concomitant pulmonary cytomegalovirus infection. The American review of respiratory disease 1991. PMID: 1648316


  106. Jacobson MA, Drew WL, Feinberg J, O'Donnell JJ, Whitmore PV, Miner RD, Parenti D. Foscarnet therapy for ganciclovir-resistant cytomegalovirus retinitis in patients with AIDS. The Journal of infectious diseases 1991. PMID: 1645385


  107. Jacobson MA, Gambertoglio JG, Aweeka FT, Causey DM, Portale AA. Foscarnet-induced hypocalcemia and effects of foscarnet on calcium metabolism. The Journal of clinical endocrinology and metabolism 1991. PMID: 1827127


  108. Jacobson MA, Besch CL, Child C, Hafner R, Muth K, Deyton L. Clinical programs for clinical research on AIDS: description of a randomized prospective study of clindamycin versus pyrimethamine for prevention of Toxoplasma gondii infection. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1991. PMID: 1676364


  109. Jacobson MA, Bacchetti P, Kolokathis A, Chaisson RE, Szabo S, Polsky B, Valainis GT, Mildvan D, Abrams D, Wilber J. Surrogate markers for survival in patients with AIDS and AIDS related complex treated with zidovudine. BMJ (Clinical research ed.) 1991. PMID: 1671651


  110. Jacobson MA, O'Donnell JJ. Approaches to the treatment of cytomegalovirus retinitis: ganciclovir and foscarnet. Journal of acquired immune deficiency syndromes 1991. PMID: 1848616


  111. Wilcox CM, Diehl DL, Cello JP, Margaretten W, Jacobson MA. Cytomegalovirus esophagitis in patients with AIDS. A clinical, endoscopic, and pathologic correlation. Annals of internal medicine 1990. PMID: 2169217


  112. Wilcox CM, Byford BA, Forsmark CE, Hadley WK, Cello JP, Jacobson MA. Campylobacter-like organisms are uncommon pathogens in patients infected with the human immunodeficiency virus. Journal of clinical microbiology 1990. PMID: 2229366


  113. Leoung GS, Feigal DW, Montgomery AB, Corkery K, Wardlaw L, Adams M, Busch D, Gordon S, Jacobson MA, Volberding PA. Aerosolized pentamidine for prophylaxis against Pneumocystis carinii pneumonia. The San Francisco community prophylaxis trial. The New England journal of medicine 1990. PMID: 1975426


  114. Farese RV, Schambelan M, Hollander H, Stringari S, Jacobson MA. Nephrogenic diabetes insipidus associated with foscarnet treatment of cytomegalovirus retinitis. Annals of internal medicine 1990. PMID: 2160217


  115. Jacobson MA, Peiperl L, Volberding PA, Porteous D, Toy PT, Feigal D. Red cell transfusion therapy for anemia in patients with AIDS and ARC: incidence, associated factors, and outcome. Transfusion 1990. PMID: 2305441


  116. Hassanzadeh MK, Aweeka FT, Wu S, Jacobson MA, Gambertoglio JG. Determination of phosphonoformic acid in human plasma and urine by high-performance liquid chromatography with electrochemical detection. Journal of chromatography 1990. PMID: 2140113


  117. Jacobson MA, O'Donnell JJ, Rousell R, Dionian B, Mills J. Failure of adjunctive cytomegalovirus intravenous immune globulin to improve efficacy of ganciclovir in patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis: a phase 1 study. Antimicrobial agents and chemotherapy 1990. PMID: 2158273


  118. Jacobson MA, Abrams DI, Volberding PA, Bacchetti P, Wilber J, Chaisson RE, Crowe S, Howard W, Moss A. Serum beta 2-microglobulin decreases in patients with AIDS or ARC treated with azidothymidine. The Journal of infectious diseases 1989. PMID: 2566637


  119. Erlich KS, Jacobson MA, Koehler JE, Follansbee SE, Drennan DP, Gooze L, Safrin S, Mills J. Foscarnet therapy for severe acyclovir-resistant herpes simplex virus type-2 infections in patients with the acquired immunodeficiency syndrome (AIDS). An uncontrolled trial. Annals of internal medicine 1989. PMID: 2522751


  120. Jacobson MA, O'Donnell JJ, Mills J. Foscarnet treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome. Antimicrobial agents and chemotherapy 1989. PMID: 2546490


  121. Aweeka F, Gambertoglio J, Mills J, Jacobson MA. Pharmacokinetics of intermittently administered intravenous foscarnet in the treatment of acquired immunodeficiency syndrome patients with serious cytomegalovirus retinitis. Antimicrobial agents and chemotherapy 1989. PMID: 2546491


  122. O'Donnell JJ, Jacobson MA. Cotton-wool spots and cytomegalovirus retinitis in AIDS. International ophthalmology clinics 1989. PMID: 2541095


  123. Small PM, McPhaul LW, Sooy CD, Wofsy CB, Jacobson MA. Cytomegalovirus infection of the laryngeal nerve presenting as hoarseness in patients with acquired immunodeficiency syndrome. The American journal of medicine 1989. PMID: 2535917


  124. Jacobson MA, McGrath MS, Joseph P, Molaghan JB, Tadepalli S, Quinn R. Zidovudine-induced fever. Journal of acquired immune deficiency syndromes 1989. PMID: 2666640


  125. Jacobson MA, Crowe S, Levy J, Aweeka F, Gambertoglio J, McManus N, Mills J. Effect of Foscarnet therapy on infection with human immunodeficiency virus in patients with AIDS. The Journal of infectious diseases 1988. PMID: 2844921


  126. Jacobson MA, Mills J, Rush J, O'Donnell JJ, Miller RG, Greco C, Gonzales MF. Failure of antiviral therapy for acquired immunodeficiency syndrome-related cytomegalovirus myelitis. Archives of neurology 1988. PMID: 2845899


  127. Jacobson MA, de Miranda P, Gordon SM, Blum MR, Volberding P, Mills J. Prolonged pancytopenia due to combined ganciclovir and zidovudine therapy. The Journal of infectious diseases 1988. PMID: 3261316


  128. Jacobson MA, Gellermann H, Chambers H. Staphylococcus aureus bacteremia and recurrent staphylococcal infection in patients with acquired immunodeficiency syndrome and AIDS-related complex. The American journal of medicine 1988. PMID: 3400693


  129. Jacobson MA, O'Donnell JJ, Brodie HR, Wofsy C, Mills J. Randomized prospective trial of ganciclovir maintenance therapy for cytomegalovirus retinitis. Journal of medical virology 1988. PMID: 2844981


  130. Mills J, Jacobson MA, O'Donnell JJ, Cederberg D, Holland GN. Treatment of cytomegalovirus retinitis in patients with AIDS. Reviews of infectious diseases 1988. PMID: 2847289


  131. Ng VL, Jacobson MA, Khayam-Bashi H, McGrath MS. Lymphoma in an HIV-positive man after disappearance of a paraprotein. The New England journal of medicine 1988. PMID: 3259675


  132. Jacobson MA, O'Donnell JJ, Porteous D, Brodie HR, Feigal D, Mills J. Retinal and gastrointestinal disease due to cytomegalovirus in patients with the acquired immune deficiency syndrome: prevalence, natural history, and response to ganciclovir therapy. The Quarterly journal of medicine 1988. PMID: 2854894


  133. Jacobson MA, Mills J. Serious cytomegalovirus disease in the acquired immunodeficiency syndrome (AIDS). Clinical findings, diagnosis, and treatment. Annals of internal medicine 1988. PMID: 2831765


  134. Jacobson MA, Cello JP, Sande MA. Cholestasis and disseminated cytomegalovirus disease in patients with the acquired immunodeficiency syndrome. The American journal of medicine 1988. PMID: 2841850


  135. Jacobson MA, de Miranda P, Cederberg DM, Burnette T, Cobb E, Brodie HR, Mills J. Human pharmacokinetics and tolerance of oral ganciclovir. Antimicrobial agents and chemotherapy 1987. PMID: 2820301


  136. O'Donnell JJ, Jacobson MA, Mills J. Development of cytomegalovirus (CMV) retinitis in a patient with AIDS during ganciclovir therapy for CMV colitis. The New England journal of medicine 1987. PMID: 3035374