Stephen Gluck, MD

HS Full Clinical Professor

Professor, Division of Nephrology
Areas of expertise: acute and chronic kidney disease, electrolyte disorders, kidney stones, outpatient and home dialysis

Publications

  1. Breeggemann MC, Gluck SL, Stoller ML, Lee MM. A Case Report of Kidney-Only Transplantation in Primary Hyperoxaluria Type 1: A Novel Approach with the Use of Nedosiran. Case reports in nephrology and dialysis 2023. PMID: 37497389


  2. Breeggemann MC, Gluck SL. Transient Hyperkalemia Following Treatment of Chronic Hypokalemia: A Case Report and Review of Distal Tubule Physiology. 2022. PMID: 35224021


  3. Khalkhali-Ellis Z, Abbott DE, Bailey CM, Goossens W, Margaryan NV, Gluck SL, Reuveni M, Hendrix MJ. IFN-gamma regulation of vacuolar pH, cathepsin D processing and autophagy in mammary epithelial cells. Volume 105 of Issue 1. Journal of cellular biochemistry 2008. PMID: 18494001


  4. Lu M, Ammar D, Ives H, Albrecht F, Gluck SL. Physical interaction between aldolase and vacuolar H+-ATPase is essential for the assembly and activity of the proton pump. Volume 282 of Issue 34. The Journal of biological chemistry 2007. PMID: 17576770


  5. Curtis LM, Gluck S. Distribution of Rab GTPases in mouse kidney and comparison with vacuolar H+-ATPase. Volume 100 of Issue 3. Nephron. Physiology 2005. PMID: 15838183


  6. Sautin YY, Lu M, Gaugler A, Zhang L, Gluck SL. Phosphatidylinositol 3-kinase-mediated effects of glucose on vacuolar H+-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cells. Volume 25 of Issue 2. Molecular and cellular biology 2005. PMID: 15632060


  7. Gluck SL. Acid sensing in renal epithelial cells. Volume 114 of Issue 12. The Journal of clinical investigation 2004. PMID: 15599393


  8. Lu M, Sautin YY, Holliday LS, Gluck SL. The glycolytic enzyme aldolase mediates assembly, expression, and activity of vacuolar H+-ATPase. Volume 279 of Issue 10. The Journal of biological chemistry 2003. PMID: 14672945


  9. Chen SH, Bubb MR, Yarmola EG, Zuo J, Jiang J, Lee BS, Lu M, Gluck SL, Hurst IR, Holliday LS. Vacuolar H+-ATPase binding to microfilaments: regulation in response to phosphatidylinositol 3-kinase activity and detailed characterization of the actin-binding site in subunit B. Volume 279 of Issue 9. The Journal of biological chemistry 2003. PMID: 14662773


  10. Holliday LS, Welgus HG, Hanna J, Lee BS, Lu M, Jeffrey JJ, Gluck SL. Interstitial collagenase activity stimulates the formation of actin rings and ruffled membranes in mouse marrow osteoclasts. Calcified tissue international 2003. PMID: 12522662


  11. Lu M, Vergara S, Zhang L, Holliday LS, Aris J, Gluck SL. The amino-terminal domain of the E subunit of vacuolar H(+)-ATPase (V-ATPase) interacts with the H subunit and is required for V-ATPase function. Volume 277 of Issue 41. The Journal of biological chemistry 2002. PMID: 12163484


  12. Lu M, Holliday LS, Zhang L, Dunn WA, Gluck SL. Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump. The Journal of biological chemistry 2001. PMID: 11399750


  13. Holliday LS, Lu M, Lee BS, Nelson RD, Solivan S, Zhang L, Gluck SL. The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site. The Journal of biological chemistry 2000. PMID: 10915794


  14. Holliday LS, Gluck SL, Slatopolsky E, Brown AJ. 1,25-Dihydroxy-19-nor-vitamin D(2), a vitamin D analog with reduced bone resorbing activity in vitro. Journal of the American Society of Nephrology : JASN 2000. PMID: 11004216


  15. Lee BS, Holliday LS, Krits I, Gluck SL. Vacuolar H+-ATPase activity and expression in mouse bone marrow cultures. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999. PMID: 10620072


  16. Lee BS, Gluck SL, Holliday LS. Interaction between vacuolar H(+)-ATPase and microfilaments during osteoclast activation. The Journal of biological chemistry 1999. PMID: 10506172


  17. Gluck SL, Lee BS, Wang SP, Underhill D, Nemoto J, Holliday LS. Plasma membrane V-ATPases in proton-transporting cells of the mammalian kidney and osteoclast. Acta physiologica Scandinavica. Supplementum 1998. PMID: 9789562


  18. Niessen H, Meisenholder GW, Li HL, Gluck SL, Lee BS, Bowman B, Engler RL, Babior BM, Gottlieb RA. Granulocyte colony-stimulating factor upregulates the vacuolar proton ATPase in human neutrophils. Blood 1997. PMID: 9373271


  19. Holliday LS, Welgus HG, Fliszar CJ, Veith GM, Jeffrey JJ, Gluck SL. Initiation of osteoclast bone resorption by interstitial collagenase. The Journal of biological chemistry 1997. PMID: 9268345


  20. Bastani B, Underhill D, Chu N, Nelson RD, Haragsim L, Gluck S. Preservation of intercalated cell H(+)-ATPase in two patients with lupus nephritis and hyperkalemic distal renal tubular acidosis. Journal of the American Society of Nephrology : JASN 1997. PMID: 9219160


  21. Wax MB, Saito I, Tenkova T, Krupin T, Becker B, Nelson N, Brown D, Gluck SL. Vacuolar H+-ATPase in ocular ciliary epithelium. Proceedings of the National Academy of Sciences of the United States of America 1997. PMID: 9192637


  22. Bastani B, Gluck S. Adaptational changes in renal vacuolar H(+)-ATPase in the rat remnant kidney. Journal of the American Society of Nephrology : JASN 1997. PMID: 9189852


  23. Holliday LS, Dean AD, Lin RH, Greenwald JE, Gluck SL. Low NO concentrations inhibit osteoclast formation in mouse marrow cultures by cGMP-dependent mechanism. The American journal of physiology 1997. PMID: 9087669


  24. Lee BS, Krits I, Crane-Zelkovic MK, Gluck SL. A novel transcription factor regulates expression of the vacuolar H+-ATPase B2 subunit through AP-2 sites during monocytic differentiation. The Journal of biological chemistry 1997. PMID: 8995244


  25. Sabolic I, Brown D, Gluck SL, Alper SL. Regulation of AE1 anion exchanger and H(+)-ATPase in rat cortex by acute metabolic acidosis and alkalosis. Kidney international 1997. PMID: 8995726


  26. Gluck SL, Iyori M, Holliday LS, Kostrominova T, Lee BS. Distal urinary acidification from Homer Smith to the present. Kidney international 1996. PMID: 8743472


  27. Bastani B, Ross FP, Kopito RR, Gluck SL. Immunocytochemical localization of vacuolar H+-ATPase and Cl--HCO3- anion exchanger (erythrocyte band-3 protein) in avian osteoclasts: effect of calcium-deficient diet on polar expression of the H+-ATPase pump. Calcified tissue international 1996. PMID: 8661962


  28. Lee BS, Holliday LS, Ojikutu B, Krits I, Gluck SL. Osteoclasts express the B2 isoform of vacuolar H(+)-ATPase intracellularly and on their plasma membranes. The American journal of physiology 1996. PMID: 8772466


  29. Gluck SL, Underhill DM, Iyori M, Holliday LS, Kostrominova TY, Lee BS. Physiology and biochemistry of the kidney vacuolar H+-ATPase. Annual review of physiology 1996. PMID: 8815802


  30. Sires UI, Schmid TM, Fliszar CJ, Wang ZQ, Gluck SL, Welgus HG. Complete degradation of type X collagen requires the combined action of interstitial collagenase and osteoclast-derived cathepsin-B. The Journal of clinical investigation 1995. PMID: 7738176


  31. Lee BS, Underhill DM, Crane MK, Gluck SL. Transcriptional regulation of the vacuolar H(+)-ATPase B2 subunit gene in differentiating THP-1 cells. The Journal of biological chemistry 1995. PMID: 7706273


  32. Gluck SL, Nelson RD, Lee BS. Properties and regulation of the renal vacuolar H(+)-ATPase and H(+)-K(+)-ATPase. Current opinion in nephrology and hypertension 1993. PMID: 7922214


  33. Gluck SL. The vacuolar H(+)-ATPases: versatile proton pumps participating in constitutive and specialized functions of eukaryotic cells. International review of cytology 1993. PMID: 8486470


  34. Gluck SL, Nelson RD, Lee BS, Wang ZQ, Guo XL, Fu JY, Zhang K. Biochemistry of the renal V-ATPase. The Journal of experimental biology 1992. PMID: 1337093


  35. Gluck SL, Nelson RD, Lee BS. Introduction to the principles and methods of recombinant DNA technology. Seminars in nephrology 1992. PMID: 1282273


  36. Gluck S, Nelson R. The role of the V-ATPase in renal epithelial H+ transport. The Journal of experimental biology 1992. PMID: 1337092


  37. Cohen EP, Bastani B, Cohen MR, Kolner S, Hemken P, Gluck SL. Absence of H(+)-ATPase in cortical collecting tubules of a patient with Sjogren's syndrome and distal renal tubular acidosis. 1992. PMID: 1391725


  38. Wang ZQ, Hemken P, Menton D, Gluck S. Expression of vacuolar H(+)-ATPase in mouse osteoclasts during in vitro differentiation. The American journal of physiology 1992. PMID: 1387291


  39. Gluck SL. The structure and biochemistry of the vacuolar H+ ATPase in proximal and distal urinary acidification. Journal of bioenergetics and biomembranes 1992. PMID: 1400280


  40. Marushack MM, Lee BS, Masood K, Gluck S. cDNA sequence and tissue expression of bovine vacuolar H(+)-ATPase M(r) 70,000 subunit. The American journal of physiology 1992. PMID: 1386191


  41. Hemken P, Guo XL, Wang ZQ, Zhang K, Gluck S. Immunologic evidence that vacuolar H+ ATPases with heterogeneous forms of Mr = 31,000 subunit have different membrane distributions in mammalian kidney. The Journal of biological chemistry 1992. PMID: 1533641


  42. Nelson RD, Guo XL, Masood K, Brown D, Kalkbrenner M, Gluck S. Selectively amplified expression of an isoform of the vacuolar H(+)-ATPase 56-kilodalton subunit in renal intercalated cells. Proceedings of the National Academy of Sciences of the United States of America 1992. PMID: 1373501


  43. Bastani B, Purcell H, Hemken P, Trigg D, Gluck S. Expression and distribution of renal vacuolar proton-translocating adenosine triphosphatase in response to chronic acid and alkali loads in the rat. The Journal of clinical investigation 1991. PMID: 1829094


  44. Schuster VL, Fejes-Tóth G, Naray-Fejes-Tóth A, Gluck S. Colocalization of H(+)-ATPase and band 3 anion exchanger in rabbit collecting duct intercalated cells. The American journal of physiology 1991. PMID: 1849362


  45. Rodman JS, Stahl PD, Gluck S. Distribution and structure of the vacuolar H+ ATPase in endosomes and lysosomes from LLC-PK1 cells. Experimental cell research 1991. PMID: 1824836


  46. Wang ZQ, Gluck S. Isolation and properties of bovine kidney brush border vacuolar H(+)-ATPase. A proton pump with enzymatic and structural differences from kidney microsomal H(+)-ATPase. The Journal of biological chemistry 1990. PMID: 2147691


  47. Blair HC, Teitelbaum SL, Ghiselli R, Gluck S. Osteoclastic bone resorption by a polarized vacuolar proton pump. Science (New York, N.Y.) 1989. PMID: 2528207


  48. Alper SL, Natale J, Gluck S, Lodish HF, Brown D. Subtypes of intercalated cells in rat kidney collecting duct defined by antibodies against erythroid band 3 and renal vacuolar H+-ATPase. Proceedings of the National Academy of Sciences of the United States of America 1989. PMID: 2526338


  49. Brown D, Hirsch S, Gluck S. Localization of a proton-pumping ATPase in rat kidney. The Journal of clinical investigation 1988. PMID: 2904451


  50. Aithal HN, Walsh-Reitz MM, Kartha S, Gluck SL, Franklin WA, Knigge KM, Toback FG. Kinetics of a novel cytosolic protein during the onset of renal epithelial cell growth. The American journal of physiology 1988. PMID: 3189562


  51. Hirsch S, Strauss A, Masood K, Lee S, Sukhatme V, Gluck S. Isolation and sequence of a cDNA clone encoding the 31-kDa subunit of bovine kidney vacuolar H+-ATPase. Proceedings of the National Academy of Sciences of the United States of America 1988. PMID: 2896353


  52. Gluck S, Caldwell J. Immunoaffinity purification and characterization of vacuolar H+ATPase from bovine kidney. The Journal of biological chemistry 1987. PMID: 2890634


  53. Yurko MA, Gluck S. Production and characterization of a monoclonal antibody to vacuolar H+ATPase of renal epithelia. The Journal of biological chemistry 1987. PMID: 2890633


  54. Brown D, Gluck S, Hartwig J. Structure of the novel membrane-coating material in proton-secreting epithelial cells and identification as an H+ATPase. The Journal of cell biology 1987. PMID: 2889740


  55. Gluck S, Al-Awqati Q. An electrogenic proton-translocating adenosine triphosphatase from bovine kidney medulla. The Journal of clinical investigation 1984. PMID: 6327769