Clinical cardiology
Authors: Cardoso R, Willems S, Gerstenfeld EP, Verma A, Schilling R, Hohnloser SH, Okumura K, Nordaby M, Brouwer MA, Calkins H
Journal of the American Geriatrics Society
Authors: Schwartz JB, Schmader KE, Hanlon JT, Abernethy DR, Gray S, Dunbar-Jacob J, Holmes HM, Murray MD, Roberts R, Joyner M, Peterson J, Lindeman D, Tai-Seale M, Downey L, Rich MW
Circulation research
Authors: Alexanian M, Haldar SM
JAMA network open
Authors: Sadhu JS, Novak E, Mukamal KJ, Kizer JR, Psaty BM, Stein PK, Brown DL
JAMA network open
Authors: Marafino BJ, Park M, Davies JM, Thombley R, Luft HS, Sing DC, Kazi DS, DeJong C, Boscardin WJ, Dean ML, Dudley RA
Neuroscience
Authors: Ferrari LF, Araldi D, Bogen O, Green PG, Levine JD
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Authors: Kim TY, Bauer DC, McNabb BL, Schafer AL, Cosman F, Black DM, Eastell R
International journal of epidemiology
Authors: Zeki Al Hazzouri A, Vittinghoff E, Zhang Y, Pletcher MJ, Moran AE, Bibbins-Domingo K, Golden SH, Yaffe K
Volume 29 of Issue 7 | Trends in cardiovascular medicine
Authors: Patel RAG, Morin DP
Volume 363 of Issue 6422 | Science (New York, N.Y.)
Authors: Harrison OJ, Linehan JL, Shih HY, Bouladoux N, Han SJ, Smelkinson M, Sen SK, Byrd AL, Enamorado M, Yao C, Tamoutounour S, Van Laethem F, Hurabielle C, Collins N, Paun A, Salcedo R, O'Shea JJ, Belkaid Y
Barrier tissues are primary targets of environmental stressors and are home to the largest number of antigen-experienced lymphocytes in the body, including commensal-specific T cells. We found that skin-resident commensal-specific T cells harbor a paradoxical program characterized by a type 17 program associated with a poised type 2 state. Thus, in the context of injury and exposure to inflammatory mediators such as interleukin-18, these cells rapidly release type 2 cytokines, thereby acquiring contextual functions. Such acquisition of a type 2 effector program promotes tissue repair. Aberrant type 2 responses can also be unleashed in the context of local defects in immunoregulation. Thus, commensal-specific T cells co-opt tissue residency and cell-intrinsic flexibility as a means to promote both local immunity and tissue adaptation to injury.
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