Publications

Department of Medicine faculty members published more than 3,000 peer-reviewed articles in 2022.

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Head & neck

Major prognostic factors for recurrence and survival independent of the American Joint Committee on Cancer eighth edition staging system in patients with cutaneous squamous cell carcinoma treated with multimodality therapy.

2018

Authors: Xu MJ, Lazar AA, Garsa AA, Arron ST, Ryan WR, El-Sayed IH, George JR, Algazi AP, Heaton CM, Ha PK, Yom SS

Human mutation

Mutations in the fourth ß-propeller domain of LRP4 are associated with isolated syndactyly with fusion of the third and fourth fingers.

2018

Authors: Sukenik Halevy R, Chien HC, Heinz B, Bamshad MJ, Nickerson DA

Clinical journal of the American Society of Nephrology : CJASN

Overcoming Translational Barriers in Acute Kidney Injury: A Report from an NIDDK Workshop.

2018

Authors: Zuk A, Palevsky PM, Fried L, Harrell FE, Khan S, McKay DB, Devey L, Chawla L, de Caestecker M, Kaufman JS, Thompson BT, Agarwal A, Greene T, Okusa MD, Bonventre JV, Dember LM, Liu KD, Humphreys BD, Gossett D, Xie Y, Norton JM, Kimmel PL, Star RA

Lung cancer (Amsterdam, Netherlands)

Economic impact of preventing brain metastases with alectinib in ALK-positive non-small cell lung cancer.

2018

Authors: Burudpakdee C, Wong W, Seetasith A, Corvino FA, Yeh W, Gubens M

Marine biology

Ocean acidification and desalination: climate-driven change in a Baltic Sea summer microplanktonic community.

2018

Authors: Wulff A, Karlberg M, Olofsson M, Torstensson A, Riemann L, Steinhoff FS, Mohlin M, Ekstrand N, Chierici M

American journal of nephrology

Race/Ethnicity, Dietary Acid Load, and Risk of End-Stage Renal Disease among US Adults with Chronic Kidney Disease.

2018

Authors: Crews DC, Banerjee T, Wesson DE, Morgenstern H, Saran R, Burrows NR, Williams DE, Powe NR

Volume 7 | eLife

IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate.

2018

Authors: Noviski M, Mueller JL, Satterthwaite A, Garrett-Sinha LA, Brombacher F, Zikherman J

View Abstract

Naive B cells co-express two BCR isotypes, IgM and IgD, with identical antigen-binding domains but distinct constant regions. IgM but not IgD is downregulated on autoreactive B cells. Because these isotypes are presumed to be redundant, it is unknown how this could impose tolerance. We introduced the Nur77-eGFP reporter of BCR signaling into mice that express each BCR isotype alone. Despite signaling strongly in vitro, IgD is less sensitive than IgM to endogenous antigen in vivo and developmental fate decisions are skewed accordingly. IgD-only B cells cannot generate autoantibodies and short-lived plasma cells (SLPCs) in vivo, a fate thought to be driven by intense BCR signaling induced by endogenous antigens. Similarly, IgD-only B cells generate normal germinal center, but impaired IgG1 SLPC responses to T-dependent immunization. We propose a role for IgD in maintaining the quiescence of autoreactive B cells and restricting their differentiation into autoantibody secreting cells.

View on PubMed

Volume 7 of Issue 6 | Journal of the American Heart Association

Single-Molecule Counting of High-Sensitivity Troponin I in Patients Referred for Diagnostic Angiography: Results From the CASABLANCA (Catheter Sampled Blood Archive in Cardiovascular Diseases) Study.

2018

Authors: McCarthy CP, Ibrahim NE, Lyass A, Li Y, Gaggin HK, Simon ML, Mukai R, Gandhi P, Kelly N, Motiwala SR, van Kimmenade RRJ, Massaro JM, D'Agostino RB, Januzzi JL

View Abstract

BACKGROUND

The meaning of high-sensitivity troponin I (hsTnI) concentrations in patients without acute myocardial infarction (MI) requires clarity. We hypothesized that among patients referred for diagnostic coronary angiography without acute MI, hsTnI concentrations would correlate with prevalent coronary artery disease (CAD) and predict incident cardiovascular events and mortality.

METHODS AND RESULTS

We measured hsTnI using a single-molecule counting assay (99th percentile, 6 ng/L) in samples from 991 patients obtained at the time of angiography. Concentrations of hsTnI were assessed relative to the severity of CAD and prognosis during mean follow-up of 3.7 years. Median hsTnI concentration was 4.19 ng/L; 38% of patients had hsTnI concentrations ≥99th percentile. Across increasing hsTnI quartiles, patients had higher prevalence of angiographic CAD; in multivariate models, hsTnI ≥99th percentile independently predicted obstructive CAD (odds ratio: 2.57; <0.001) and incident MI (hazard ratio [HR]: 2.68; <0.001), cardiovascular death (HR: 2.29; =0.001), and all-cause death (HR: 1.84; =0.004). In those with >70% coronary stenosis, hsTnI ≥99th percentile independently predicted incident MI (HR: 1.87; =0.01), cardiovascular mortality (HR: 2.74; =0.001), and the composite end point of MI and all-cause death (HR: 2.06; <0.001). In participants with coronary stenosis <70%, hsTnI ≥99th percentile even more strongly predicted incident MI (HR: 8.41; <0.001), cardiovascular mortality (HR: 3.60; =0.03), and the composite end point of MI and all-cause death (HR: 3.62; <0.001).

CONCLUSIONS

In a large prospective cohort of patients who were free of prevalent MI and undergoing diagnostic coronary angiography, hsTnI concentrations were associated with higher prevalence of CAD and predicted incident MI, cardiovascular death, and all-cause death.