Journal of global oncology
Authors: Mmbaga EJ, Deardorff KV, Mushi B, Mgisha W, Merritt M, Hiatt RA, Mwaiselage J, Zhang L, Van Loon K
Families, systems & health : the journal of collaborative family healthcare
Authors: Mao AY, Willard-Grace R, Dubbin L, Aronson L, Fernandez A, Burke NJ, Finch J, Davis E
International journal of STD & AIDS
Authors: Baillargeon J, Pulvino JS, Leonardson JE, Linthicum LC, Williams B, Penn J, Williams RS, Baillargeon G, Murray OJ
Volume 7 of Issue 9 | Cancer discovery
Authors: Quigley D, Alumkal JJ, Wyatt AW, Kothari V, Foye A, Lloyd P, Aggarwal R, Kim W, Lu E, Schwartzman J, Beja K, Annala M, Das R, Diolaiti M, Pritchard C, Thomas G, Tomlins S, Knudsen K, Lord CJ, Ryan C, Youngren J, Beer TM, Ashworth A, Small EJ, Feng FY
Approximately 20% of metastatic prostate cancers harbor mutations in genes required for DNA repair by homologous recombination repair (HRR) such as HRR defects confer synthetic lethality to PARP inhibitors (PARPi) such as olaparib and talazoparib. In ovarian or breast cancers, olaparib resistance has been associated with HRR restoration, including by mutation reversion. Whether similar mechanisms operate in prostate cancer, and could be detected in liquid biopsies, is unclear. Here, we identify reversion mutations associated with olaparib and talazoparib resistance in patients with prostate cancer. Analysis of circulating cell-free DNA (cfDNA) reveals reversion mutation heterogeneity not discernable from a single solid-tumor biopsy and potentially allows monitoring for the emergence of PARPi resistance. The mechanisms of clinical resistance to PARPi in DNA repair-deficient prostate cancer have not been described. Here, we show reversion mutations in patients with prostate cancer with metastatic disease who developed resistance to talazoparib and olaparib. Furthermore, we show that PARPi resistance is highly multiclonal and that cfDNA allows monitoring for PARPi resistance. .
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Journal of investigative medicine high impact case reports
Authors: Hannaford A, Del Bello D, Leng S, Chari A, Perumalswami P, Dieterich D, Branch A
Clinical journal of the American Society of Nephrology : CJASN
Authors: Ikeme JC, Pergola PE, Scherzer R, Shlipak MG, Benavente OR, Peralta CA
JACC. Clinical electrophysiology
Authors: Yadav AV, Nazer B, Drew BJ, Miller JM, El Masry H, Groh WJ, Natale A, Marrouche N, Badhwar N, Yang Y, Scheinman MM
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Authors: Park M, Katz R, Shlipak MG, Weiner D, Tracy R, Jotwani V, Hughes-Austin J, Gabbai F, Hsu CY, Pfeffer M, Bansal N, Bostom A, Gutierrez O, Sarnak M, Levey A, Ix JH
Thorax
Authors: Faust HE, Golden JA, Rajalingam R, Wang AS, Green G, Hays SR, Kukreja J, Singer JP, Wolters PJ, Greenland JR
Chemical biology & drug design
Authors: Singh A, Rani A, Gut J, Rosenthal PJ, Kumar V
