Publications

Department of Medicine faculty members published more than 3,000 peer-reviewed articles in 2022.

Filter by

Volume 31 of Issue 5 | AIDS (London, England)

Limitations of using the Lorenz curve framework to understand the distribution of population viral load: authors' reply.

2017

Authors: Christopoulos KA, Hartogensis W, Glidden DV, Pilcher CD, Gandhi M, Geng EH

Volume 8 of Issue 42 | Oncotarget

Androgen receptor amplification is concordant between circulating tumor cells and biopsies from men undergoing treatment for metastatic castration resistant prostate cancer.

2017

Authors: Podolak J, Eilers K, Newby T, Slottke R, Tucker E, Olson SB, Lue HW, Youngren J, Aggarwal R, Small EJ, Graff JN, Alumkal JJ, Beer TM, Thomas GV

View Abstract

Increased activity has been shown to be preserved in spatially distinct metastatic tumors from the same patient suggesting the requirement for lineage-specific dependencies for metastatic castration resistant prostate cancer (mCRPC). Amplification of the gene is a common mechanism by which mCRPC increase activity. To determine whether amplification in circulating tumor cells (CTC) could complement metastatic tissue biopsies in men undergoing treatment for mCRPC, we developed a novel two-step assay to isolate CTCs and subsequently analyzed amplification status in CTCs and matched biopsy tissue from the same patient by fluorescence hybridization (FISH). gene status in CTCs showed strong concordance with gene status in matched tissue samples in 24 of 25 patients (Correlation: 96%; Kappa: 0.83; Sensitivity: 100%, Specificity: 83%). Our work demonstrates that amplification is conserved between CTCs and biopsies and that CTCs can serve as non-invasive surrogate to document amplification in mCRPC.

View on PubMed

American journal of nephrology

Oxidative Balance Score and the Risk of End-Stage Renal Disease and Cardiovascular Disease.

2017

Authors: Ilori TO, Wang X, Huang M, Gutierrez OM, Narayan KM, Goodman M, McClellan W, Plantinga L, Ojo AO

Improving documentation of surrogate decision makers in medical oncology clinic.

2017

Authors:

Nature reviews. Drug discovery

Marked for death: targeting epigenetic changes in cancer.

2017

Authors: Pfister SX, Ashworth A

Heart rhythm

Cardiac autonomic neuromodulation: Can "kilohertz frequency" reduce arrhythmia frequency?

2017

Authors: Nazer B, Gerstenfeld EP

European journal of heart failure

Measurement of troponin and natriuretic peptides shortly after admission in patients with heart failure-does it add useful prognostic information? An analysis of the Value of Endothelin Receptor Inhibition with Tezosentan in Acute heart failure Studies (V

2017

Authors: Cleland JGF, Teerlink JR, Davison BA, Shoaib A, Metra M, Senger S, Milo O, Cotter G, Bourge RC, Parker JD, Jondeau G, Krum H, O'Connor CM, Torre-Amione G, van Veldhuisen DJ, McMurray JJV

Breast (Edinburgh, Scotland)

Efficacy of NEPA (netupitant/palonosetron) across multiple cycles of chemotherapy in breast cancer patients: A subanalysis from two phase III trials.

2017

Authors: Rugo HS, Rossi G, Rizzi G, Aapro M

International journal of hygiene and environmental health

Exposure to polycyclic aromatic hydrocarbons and volatile organic compounds among recently pregnant rural Guatemalan women cooking and heating with solid fuels.

2017

Authors: Weinstein JR, Asteria-Peñaloza R, Diaz-Artiga A, Davila G, Hammond SK, Ryde IT, Meyer JN, Benowitz N, Thompson LM

Science immunology

Natural killer cell-mediated inflammation resolution is disabled in severe asthma.

2017

Authors: Duvall MG, Barnig C, Cernadas M, Ricklefs I, Krishnamoorthy N, Grossman NL, Bhakta NR, Fahy JV, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Israel E, Levy BD