Publications

Department of Medicine faculty members published more than 3,000 peer-reviewed articles in 2022.

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Frontiers in psychiatry

Feasibility and Preliminary Efficacy of a Novel RDoC-Based Treatment Program for Adolescent Depression: "Training for Awareness Resilience and Action" (TARA)-A Pilot Study.

2017

Authors: Henje Blom E, Tymofiyeva O, Chesney MA, Ho TC, Moran P, Connolly CG, Duncan LG, Baldini L, Weng HY, Acree M, Goldman V, Hecht FM, Yang TT

American journal of respiratory and critical care medicine

Reply: The New Idiopathic Pulmonary Fibrosis Acute Exacerbations Document: One Step Ahead but Still Suspended in the Air.

2017

Authors: Ryerson CJ, Corte TJ, Martinez FJ, Collard HR

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

Improving Accuracy of Home Sleep Apnea Testing.

2017

Authors: Claman D, Sunwoo B

Development (Cambridge, England)

Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes.

2017

Authors: Hu DP, Ferro F, Yang F, Taylor AJ, Chang W, Miclau T, Marcucio RS, Bahney CS

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

Treatment of OSA with CPAP Is Associated with Improvement in PTSD Symptoms among Veterans.

2017

Authors: Orr JE, Smales C, Alexander TH, Stepnowsky C, Pillar G, Malhotra A, Sarmiento KF

Immediate initiation of cART is associated with lower levels of cerebrospinal fluid YKL-40, a marker of microglial activation, in HIV-1 infection.

2017

Authors: Peluso MJ, Valcour V, Phanuphak N, Ananworanich J, Fletcher JL, Chalermchai T, Krebs SJ, Robb ML, Hellmuth J, Gisslén M, Zetterberg H, Spudich S, RV254SEARCH 010, RV304SEARCH 013, and SEARCH 011 Study Teams

View Abstract

OBJECTIVE

To characterize cerebrospinal fluid (CSF) YKL-40, a unique biomarker that reflects activation of microglial cells, in acute (AHI) and chronic HIV-1 infection (CHI) and to determine the effect of treatment initiation on levels of this marker.

DESIGN

A cross-sectional study of two groups of HIV-infected participants at baseline and follow-up timepoints.

METHODS

AHI (n = 33) and CHI (n = 34) participants underwent CSF and blood sampling before treatment initiation with combination antiretroviral therapy (cART) and at follow-up on cART in a subset of these individuals [6 months in AHI participants (n = 24), 1 year in CHI participants (n = 10)]. Measured parameters were analyzed at each timepoint. Analyses employed Mann-Whitney tests and Spearman correlations.

RESULTS

Baseline median YKL-40 was higher in CHI than AHI (96844 versus 80754 ng/l; P = 0.011). Elevations in the CHI group relative to the AHI group persisted at follow-up despite treatment (87414 versus 66130 ng/l; P = 0.003). In untreated CHI, YKL-40 correlated with neopterin (r = 0.51, P = 0.0025), chemokine (CXC-motif) ligand-10 (r = 0.44, P = 0.011), and neurofilament light chain (r = 0.56, P = 0.0008) in CSF.

CONCLUSIONS

This study is the first to describe the dynamics of CSF YKL-40 in two groups of HIV-infected individuals before and after cART and demonstrates the value of this marker in understanding HIV neuropathogenesis. The results suggest the utility of further exploring the prognostic value of YKL-40, particularly in individuals with early HIV infection or those initiating treatment during CHI.

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AIDS (London, England)

Increased glucose transporter-1 expression on intermediate monocytes from HIV-infected women with subclinical cardiovascular disease.

2017

Authors: Butterfield TR, Hanna DB, Kaplan RC, Kizer JR, Durkin HG, Young MA, Nowicki MJ, Tien PC, Golub ET, Floris-Moore MA, Titanji K, Fischl MA, Heath SL, Martinson J, Crowe SM, Palmer CS, Landay AL, Anzinger JJ

Volume 31 of Issue 2 | AIDS (London, England)

The Lorenz curve: a novel method for understanding viral load distribution at the population level.

2017

Authors: Christopoulos KA, Hartogensis W, Glidden DV, Pilcher CD, Gandhi M, Geng EH

View Abstract

Existing HIV care cascade metrics fail to capture whether viremia is equally distributed in a population or concentrated within groups. We applied the Lorenz curve, which has been used to describe disparities in the distribution of income and other resources, to the distribution of viremia in a safety-net HIV clinic in 2012. Among 1855 established clinic patients, 1% of the population held 50% of the virus and 10% of the population held 94% of virus.

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Kidney international

Glucocorticoid-induced leucine zipper protein regulates sodium and potassium balance in the distal nephron.

2017

Authors: Rashmi P, Colussi G, Ng M, Wu X, Kidwai A, Pearce D

Scientific Reports

Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals.

2017

Authors: Tauriainen J, Scharf L, Frederiksen J, Naji A, Ljunggren HG, Sönnerborg A, Lund O, Reyes-Terán G, Hecht FM, Deeks SG, Betts MR, Buggert M, Karlsson AC