Publications
Department of Medicine faculty members published more than 3,000 peer-reviewed articles in 2022.
1983
1983
Response of adenylate cyclase to parathyroid hormone and prostaglandins by human isolated glomeruli.
1983
1983
(--)-alpha-Acetylmethadol effects on alcohol and diazepam use, sexual function and cardiac function.
1983
1983
1983
1983
1983
Autoantibody-secreting hybridomas were produced by somatic cell fusion of B lymphocytes from a patient with systemic lupus erythematosus with two different human myeloma lines. Selection of hybrids formed from one of these cell lines was performed by using aminopterine-containing culture medium as this cell line was deficient in hypoxanthine-guanine-phosphoribosyl transferase (HGPRT). The second myeloma line was not HGPRT-deficient but instead was treated with diethylpyrocarbonate, which assured death of unfused myeloma cells. This novel technique has wide applicability. Hybridomas were found to secrete antibodies to native DNA and to extractable nuclear antigen. The binding specificities of one IgM anti-DNA antibody was characterized and found to be specific for double-stranded DNA and had particular binding affinity for poly(dG) . poly(dC).
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