Buck Strewler, MD

Professor & Senior Advisor

Gordon "Buck" Strewler grew up in northern Minnesota and graduated from Dartmouth College and Harvard Medical School. He was an intern and resident at Peter Bent Brigham Hospital, the predecessor of Brigham and Women's. After clinical and research training in Endocrinology-Metabolism at the National Institutes of Health, he joined the UCSF faculty in 1979. He is an expert in calcium and bone metabolism; With Robert Nissenson, PhD,his laboratory identified, sequenced and cloned the parathyroid hormone-related protein, PTHrP, developed an assay to detect PTHrP in patients with hypercalcemia, and led the way to the understanding of its role in disease. He was Chief of the Endocrine Unit at the SFVAMC and also directed the UCSF Endocrinology Fellowship Program. Dr. Strewler returned to Boston in 1996. He was Chief of Medicine at the West Roxbury VA Medical Center (now part of the VA Boston Healthcare System) until 2001, when he became Master of the Walter Bradford Cannon Society, one of five learning communities in which Harvard medical students spend their academic lives. He subsequently became Director of the Scholars in Medicine program at HMS and Vice Chair for Education in the department of medicine at Beth Israel Deaconess Medical Center. He returned to UCSF in September, 2015 to join the Inquiry leadership team.

Education
Fellowship, 1979 - Endocrinology-Metabolism, NHLBI/NIH
Internship and Residency, 1973 - , Peter Bent Brigham Hospital
M.D., 1971 - , Harvard Medical School
A.B., 1968 - , Dartmouth College
Honors and Awards
  • Tutorial Excellence Award, Harvard Medical School, 2014
  • Mentorship of Resident Research Award, Dept of Medicine, Beth Israel Deaconess, 2009
  • Best Doctors in Boston, Boston Magazine, 2006
  • Best Lecturer, Module 2, HMS Second Year Class, 2003
  • Elected to Aesculapian Club, Harvard Medical School, 2003
  • Best Doctors in America, 1996
  • American Society for Clinical Investigation, 1987
Publications

  1. Krupat E, Camargo CA, Espinola JA, Fleenor TJ, Strewler GJ, Dienstag JL. A snapshot of underrepresented physicians 15 years after medical school. Volume 25 of Issue 3. Advances in health sciences education : theory and practice 2020. PMID: 31982974


  2. Brondfield S, Boscardin C, Strewler G, Hyland K, Oakes SA, Nishimura H, Crawford J, Hauer KE. A Medical Student Inquiry Behavior Assessment Tool: Development and Validity Evidence. Academic medicine : journal of the Association of American Medical Colleges 2019. PMID: 30431452


  3. Libman H, Malabanan AO, Strewler GJ, Reynolds EE. Should We Screen for Vitamin D Deficiency?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center. Volume 165 of Issue 11. Annals of internal medicine 2016. PMID: 27919096


  4. Krupat E, Camargo CA, Strewler GJ, Espinola JA, Fleenor TJ, Dienstag JL. Factors associated with physicians' choice of a career in research: a retrospective report 15 years after medical school graduation. Volume 22 of Issue 1. Advances in health sciences education : theory and practice 2016. PMID: 27112959


  5. Farag N, Delbanco T, Strewler GJ. Update: A 64-year-old woman with primary hyperparathyroidism. Volume 300 of Issue 17. JAMA 2008. PMID: 18984891


  6. Strewler GJ. Untangling klotho's role in calcium homeostasis. Volume 6 of Issue 2. Cell metabolism 2007. PMID: 17681143


  7. Wang EP, Kaban LB, Strewler GJ, Raje N, Troulis MJ. Incidence of osteonecrosis of the jaw in patients with multiple myeloma and breast or prostate cancer on intravenous bisphosphonate therapy. Volume 65 of Issue 7. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 2007. PMID: 17577497


  8. Strewler GJ. A 64-year-old woman with primary hyperparathyroidism. Volume 293 of Issue 14. JAMA 2005. PMID: 15827317


  9. Elmquist JK, Strewler GJ. Physiology: do neural signals remodel bone? Volume 434 of Issue 7032. Nature 2005. PMID: 15791237


  10. Strewler GJ. Decimal point--osteoporosis therapy at the 10-year mark. Volume 350 of Issue 12. The New England journal of medicine 2004. PMID: 15028820


  11. Strewler GJ. FGF23, hypophosphatemia, and rickets: has phosphatonin been found? Volume 98 of Issue 11. Proceedings of the National Academy of Sciences of the United States of America 2001. PMID: 11371627


  12. Strewler GJ. Local and systemic control of the osteoblast. Volume 107 of Issue 3. The Journal of clinical investigation 2001. PMID: 11160149


  13. Strewler GJ. Medical approaches to primary hyperparathyroidism. Volume 29 of Issue 3. Endocrinology and metabolism clinics of North America 2000. PMID: 11033759


  14. Strewler GJ. The parathyroid hormone-related protein. Volume 29 of Issue 3. Endocrinology and metabolism clinics of North America 2000. PMID: 11033764


  15. Strewler GJ. The physiology of parathyroid hormone-related protein. Volume 342 of Issue 3. The New England journal of medicine 2000. PMID: 10639544


  16. Chang W, Tu C, Bajra R, Komuves L, Miller S, Strewler G, Shoback D. Calcium sensing in cultured chondrogenic RCJ3.1C5.18 cells. Endocrinology 1999. PMID: 10098531


  17. Lane NE, Kimmel DB, Nilsson MH, Cohen FE, Newton S, Nissenson RA, Strewler GJ. Bone-selective analogs of human PTH(1-34) increase bone formation in an ovariectomized rat model. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1996. PMID: 9157776


  18. Funk JL, Moser AH, Strewler GJ, Feingold KR, Grünfeld C. Parathyroid hormone-related protein is induced during lethal endotoxemia and contributes to endotoxin-induced mortality in rodents. Volume 2 of Issue 2. Molecular medicine (Cambridge, Mass.) 1996. PMID: 8726463


  19. Lane NE, Thompson JM, Strewler GJ, Kinney JH. Intermittent treatment with human parathyroid hormone (hPTH[1-34]) increased trabecular bone volume but not connectivity in osteopenic rats. Volume 10 of Issue 10. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1995. PMID: 8686502


  20. Funk JL, Lausier J, Moser AH, Shigenaga JK, Huling S, Nissenson RA, Strewler GJ, Grunfeld C, Feingold KR. Endotoxin induces parathyroid hormone-related protein gene expression in splenic stromal and smooth muscle cells, not in splenic lymphocytes. Endocrinology 1995. PMID: 7628377


  21. Strewler GJ. Indications for surgery in patients with minimally symptomatic primary hyperparathyroidism. Volume 75 of Issue 3. The Surgical clinics of North America 1995. PMID: 7747251


  22. Funk JL, Shigenaga JK, Moser AH, Krul EJ, Strewler GJ, Feingold KR, Grunfeld C. Cytokine regulation of parathyroid hormone-related protein messenger ribonucleic acid levels in mouse spleen: paradoxical effects of interferon-gamma and interleukin-4. Endocrinology 1994. PMID: 7516868


  23. Schermer DT, Bradley MS, Bambino TH, Nissenson RA, Strewler GJ. Functional properties of a synthetic chicken parathyroid hormone-related protein 1-36 fragment. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994. PMID: 7942150


  24. Strewler GJ. Familial benign hypocalciuric hypercalcemia--from the clinic to the calcium sensor. Volume 160 of Issue 6. The Western journal of medicine 1994. PMID: 8053190


  25. Funk JL, Krul EJ, Moser AH, Shigenaga JK, Strewler GJ, Grunfeld C, Feingold KR. Endotoxin increases parathyroid hormone-related protein mRNA levels in mouse spleen. Mediation by tumor necrosis factor. The Journal of clinical investigation 1993. PMID: 8227368


  26. Strewler GJ, Budayr AA, Clark OH, Nissenson RA. Production of parathyroid hormone by a malignant nonparathyroid tumor in a hypercalcemic patient. The Journal of clinical endocrinology and metabolism 1993. PMID: 7684395


  27. Marino MT, Asp AA, Budayer AA, Marsden JS, Strewler GJ. Hypercalcaemia and elevated levels of parathyroid hormone-related protein in cutaneous squamous/basal cell carcinoma. Volume 233 of Issue 2. Journal of internal medicine 1993. PMID: 8433083


  28. Chan SD, Karpf DB, Fowlkes ME, Hooks M, Bradley MS, Vuong V, Bambino T, Liu MY, Arnaud CD, Strewler GJ. Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues. Volume 267 of Issue 35. The Journal of biological chemistry 1992. PMID: 1334084


  29. Strewler GJ, Chan SD, Globus RK, Schermer DT, Nissenson RA. Actions of parathyroid hormone-related protein as an embryonic differentiation factor. Journal of endocrinological investigation 1992. PMID: 1300340


  30. Klein RF, Nissenson RA, Strewler GJ. Pertussis toxin inhibits hormonal stimulation of bone resorption in fetal rat limb bones. The Journal of pharmacology and experimental therapeutics 1991. PMID: 1653845


  31. Schermer DT, Chan SD, Bruce R, Nissenson RA, Wood WI, Strewler GJ. Chicken parathyroid hormone-related protein and its expression during embryologic development. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1991. PMID: 1709333


  32. Cohen FE, Strewler GJ, Bradley MS, Carlquist M, Nilsson M, Ericsson M, Ciardelli TL, Nissenson RA. Analogues of parathyroid hormone modified at positions 3 and 6. Effects on receptor binding and activation of adenylyl cyclase in kidney and bone. The Journal of biological chemistry 1991. PMID: 1846369


  33. Strewler GJ, Nissenson RA. Hypercalcemia in malignancy. The Western journal of medicine 1990. PMID: 2293469


  34. Chan SD, Strewler GJ, Nissenson RA. Transcriptional activation of Gs alpha expression by retinoic acid and parathyroid hormone-related protein in F9 teratocarcinoma cells. The Journal of biological chemistry 1990. PMID: 2122968


  35. Chan SD, Strewler GJ, King KL, Nissenson RA. Expression of a parathyroid hormone-like protein and its receptor during differentiation of embryonal carcinoma cells. Molecular endocrinology (Baltimore, Md.) 1990. PMID: 2177844


  36. Strewler GJ, Nissenson RA. Peptide mediators of hypercalcemia in malignancy. Annual review of medicine 1990. PMID: 2184736


  37. Budayr AA, Nissenson RA, Klein RF, Pun KK, Clark OH, Diep D, Arnaud CD, Strewler GJ. Increased serum levels of a parathyroid hormone-like protein in malignancy-associated hypercalcemia. Annals of internal medicine 1989. PMID: 2817628


  38. Budayr AA, Halloran BP, King JC, Diep D, Nissenson RA, Strewler GJ. High levels of a parathyroid hormone-like protein in milk. Proceedings of the National Academy of Sciences of the United States of America 1989. PMID: 2550932


  39. Nissenson RA, Diep D, Strewler GJ. Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney. The Journal of biological chemistry 1988. PMID: 2843501


  40. Klein RF, Nissenson RA, Strewler GJ. Forskolin mimics the effects of calcitonin but not parathyroid hormone on bone resorption in vitro. Bone and mineral 1988. PMID: 2847839


  41. Thiede MA, Strewler GJ, Nissenson RA, Rosenblatt M, Rodan GA. Human renal carcinoma expresses two messages encoding a parathyroid hormone-like peptide: evidence for the alternative splicing of a single-copy gene. Proceedings of the National Academy of Sciences of the United States of America 1988. PMID: 3290897


  42. Strewler GJ, Stern PH, Jacobs JW, Eveloff J, Klein RF, Leung SC, Rosenblatt M, Nissenson RA. Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone. The Journal of clinical investigation 1987. PMID: 3680530


  43. Klein RF, Strewler GJ, Leung SC, Nissenson RA. Parathyroid hormone-like adenylate cyclase-stimulating activity from a human carcinoma is associated with bone-resorbing activity. Endocrinology 1987. PMID: 3026777


  44. Strewler GJ, Nissenson RA. Nonparathyroid hypercalcemia. Advances in internal medicine 1987. PMID: 3030065


  45. Strewler GJ, Wronski TJ, Halloran BP, Miller SC, Leung SC, Williams RD, Nissenson RA. Pathogenesis of hypercalcemia in nude mice bearing a human renal carcinoma. Endocrinology 1986. PMID: 3013591


  46. Pollock AS, Warnock DG, Strewler GJ. Parathyroid hormone inhibition of Na+-H+ antiporter activity in a cultured renal cell line. Volume 250 of Issue 2 Pt 2. The American journal of physiology 1986. PMID: 2418691


  47. Nissenson RA, Strewler GJ, Williams RD, Leung SC. Activation of the parathyroid hormone receptor-adenylate cyclase system in osteosarcoma cells by a human renal carcinoma factor. Cancer research 1985. PMID: 2996759


  48. Stern PH, Krieger NS, Nissenson RA, Williams RD, Winkler ME, Derynck R, Strewler GJ. Human transforming growth factor-alpha stimulates bone resorption in vitro. The Journal of clinical investigation 1985. PMID: 3877079


  49. Bikle DD, Genant HK, Cann C, Recker RR, Halloran BP, Strewler GJ. Bone disease in alcohol abuse. Annals of internal medicine 1985. PMID: 2988390


  50. Pollock AS, Strewler GJ, Miller RT, Lawlor D, Horowitz DD, Warnock DG. Biologic regulation of Na/H antiporter activity in a cultured kidney cell line: effects of parathyroid hormone (PTH). Volume 456. Annals of the New York Academy of Sciences 1985. PMID: 3867312


  51. Strewler GJ. Paget's disease of bone. Volume 140 of Issue 5. The Western journal of medicine 1984. PMID: 6730492


  52. Teitelbaum AP, Strewler GJ. Parathyroid hormone receptors coupled to cyclic adenosine monophosphate formation in an established renal cell line. Volume 114 of Issue 3. Endocrinology 1984. PMID: 6321147


  53. Strewler GJ. Release of cAMP from a renal epithelial cell line. Volume 246 of Issue 3 Pt 1. The American journal of physiology 1984. PMID: 6322592


  54. Gogel E, Halloran BP, Strewler GJ. Probenecid inhibits the secretion of nephrogenous adenosine 3',5'-monophosphate in normal man. The Journal of clinical endocrinology and metabolism 1983. PMID: 6309880


  55. Strewler GJ, Danello MA, Manganiello VC, Vaughan M. Ca2+-independent cyclic GMP phosphodiesterases from rat liver and HTC hepatoma cells. Volume 213 of Issue 2. The Biochemical journal 1983. PMID: 6311163


  56. Strewler GJ, Williams RD, Nissenson RA. Human renal carcinoma cells produce hypercalcemia in the nude mouse and a novel protein recognized by parathyroid hormone receptors. The Journal of clinical investigation 1983. PMID: 6298282


  57. Strewler GJ, Fallon BG, Orloff J. Defective protein phosphorylation in renal medulla of vasopressin-resistant mice. Volume 103 of Issue 2. Biochemical and biophysical research communications 1981. PMID: 7332566


  58. Vaughan M, Danello MA, Manganiello VC, Strewler GJ. Regulation of cyclic nucleotide phosphodiesterase activity. Volume 14. Advances in cyclic nucleotide research 1981. PMID: 6169258


  59. Strewler GJ, Manganiello VC. Purification and characterization of phosphodiesterase activator from kidney. A lysosomal protease. Volume 254 of Issue 23. The Journal of biological chemistry 1979. PMID: 227882


  60. Pinkett MO, Strewler GJ, Anderson WB. Stimulation of adenylate cyclase activity by a protease which activates cyclic nucleotide phosphodiesterase. Volume 90 of Issue 4. Biochemical and biophysical research communications 1979. PMID: 229831


  61. Strewler GJ, Manganiello VC, Vaughan M. Phosphodiesterase activator from rat kidney cortex. Volume 253 of Issue 2. The Journal of biological chemistry 1978. PMID: 201632


  62. Eastman RC, Come SE, Strewler GJ, Gorden P, Kahn CR. Adriamycin therapy for advanced insulinoma. Volume 44 of Issue 1. The Journal of clinical endocrinology and metabolism 1977. PMID: 188859


  63. Strewler GJ, Orloff J. Role of cyclic nucleotides in the transport of water and electrolytes. Volume 8. Advances in cyclic nucleotide research 1977. PMID: 200128


  64. Rothman IK, Alter HJ, Strewler GJ. Delayed overt hemolytic transfusion reaction due to anti-U antibody. Volume 16 of Issue 4. Transfusion 1976. PMID: 951732


  65. Strewler GJ, Bernstein DS, Pletka P. Pseudo-vitamin D deficiency rickets (PDR) and relative hypoparathyroidism: a report of a family. Volume 37 of Issue 2. The Journal of clinical endocrinology and metabolism 1973. PMID: 4720069


  66. Strewler GJ, Hinrichs KJ, Guiod LR, Hollenberg NK. Sodium intake and vascular smooth muscle responsiveness to norepinephrine and angiotensin in the rabbit. Volume 31 of Issue 5. Circulation research 1972. PMID: 4343577


  67. Woods BT, Strewler GJ. Hemiparesis occurring six hours after intravenous heroin injection. Volume 22 of Issue 8. Neurology 1972. PMID: 4673415


  68. Mudge GH, Strewler GJ, Desbiens N, Berndt WO, Wade DN. Excretion and distribution of iophenoxic acid. Volume 178 of Issue 1. The Journal of pharmacology and experimental therapeutics 1971. PMID: 5087394


  69. Wade DN, Desbiens N, Strewler GJ, Berndt WO, Mudge GH. Metabolism of iophenoxic acid in the dog. Volume 178 of Issue 1. The Journal of pharmacology and experimental therapeutics 1971. PMID: 5087395