Chris Lau, PhD

Adjunct Professor

Publications

  1. Vogt PH, Besikoglu B, Bettendorf M, Frank-Herrmann P, Zimmer J, Bender U, Knauer-Fischer S, Choukair D, Sinn P, Doerr HG, Woelfle J, Heidemann PH, Lau YC, Strowitzki T. Sex chromosome DSD individuals with mosaic 45,X0 and aberrant Y chromosomes in 46,XY cells: distinct gender phenotypes and germ cell tumour risks§. Systems biology in reproductive medicine 2022. PMID: 35481403


  2. Lau YC. The 2020 Ming K. Jeang awards for excellence in Cell & Bioscience. 2021. PMID: 34906230


  3. Lau YC. Y chromosome in health and diseases. Cell & bioscience 2020. PMID: 32817785


  4. Kido T, Tabatabai ZL, Chen X, Lau YC. Potential dual functional roles of the Y-linked RBMY in hepatocarcinogenesis. Cancer science 2020. PMID: 32473614


  5. Lau YC, Li Y, Kido T. Battle of the sexes: contrasting roles of testis-specific protein Y-encoded (TSPY) and TSPX in human oncogenesis. Asian journal of andrology 2018. PMID: 29974883


  6. Vogt PH, Besikoglu B, Bettendorf M, Frank-Herrmann P, Zimmer J, Bender U, Knauer-Fischer S, Choukair D, Sinn P, Lau YC, Heidemann PH, Strowitzki T. Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include DDX3Y and TSPY. Human reproduction (Oxford, England) 2019. PMID: 30753444


  7. Kido T, Lau YC. The Y-linked proto-oncogene TSPY contributes to poor prognosis of the male hepatocellular carcinoma patients by promoting the pro-oncogenic and suppressing the anti-oncogenic gene expression. Cell & bioscience 2019. PMID: 30867900


  8. Kido T, Li Y, Tanaka Y, Dahiya R, Chris Lau YF. The X-linked tumor suppressor TSPX downregulates cancer-drivers/oncogenes in prostate cancer in a C-terminal acidic domain dependent manner. Oncotarget 2019. PMID: 30863497


  9. Kido T, Sun Z, Lau YC. Aberrant activation of the human sex-determining gene in early embryonic development results in postnatal growth retardation and lethality in mice. Scientific Reports 2017. PMID: 28646221


  10. Li Y, Zhang DJ, Qiu Y, Kido T, Lau YC. The Y-located proto-oncogene TSPY exacerbates and its X-homologue TSPX inhibits transactivation functions of androgen receptor and its constitutively active variants. Human molecular genetics 2017. PMID: 28169398


  11. Kido T, Lau YC. Identification of a TSPY co-expression network associated with DNA hypomethylation and tumor gene expression in somatic cancers. Journal of genetics and genomics = Yi chuan xue bao 2016. PMID: 27771326


  12. Fukuhara S, Chang I, Mitsui Y, Chiyomaru T, Yamamura S, Majid S, Saini S, Deng G, Gill A, Wong DK, Shiina H, Nonomura N, Lau YF, Dahiya R, Tanaka Y. Functional role of DNA mismatch repair gene PMS2 in prostate cancer cells. Oncotarget 2015. PMID: 26036629


  13. Kido T, Lau YF. Roles of the Y chromosome genes in human cancers. Asian journal of andrology 2015. PMID: 25814157


  14. Li Y, Kido T, Garcia-Barcelo MM, Tam PK, Tabatabai ZL, Lau YF. SRY interference of normal regulation of the RET gene suggests a potential role of the Y-chromosome gene in sexual dimorphism in Hirschsprung disease. Human molecular genetics 2014. PMID: 25267720


  15. Li Y, Zheng M, Lau YF. The sex-determining factors SRY and SOX9 regulate similar target genes and promote testis cord formation during testicular differentiation. Cell reports 2014. PMID: 25088423


  16. Kido T, Lo RC, Li Y, Lee J, Tabatabai ZL, Ng IO, Lau YF. The potential contributions of a Y-located protooncogene and its X homologue in sexual dimorphisms in hepatocellular carcinoma. Human pathology 2014. PMID: 25017435


  17. Kido T, Lau YF. The Y-located gonadoblastoma gene TSPY amplifies its own expression through a positive feedback loop in prostate cancer cells. Biochemical and biophysical research communications 2014. PMID: 24583132


  18. Kido T, Schubert S, Hatakeyama S, Ohyama C, Schmidtke J, Lau YF. Expression of a Y-located human proto-oncogene TSPY in a transgenic mouse model of prostate cancer. Cell & bioscience 2014. PMID: 24528896


  19. Zheng M, Li Y, Lau YF. Application of the simple and efficient Mpeak modeling in binding peak identification in ChIP-chip studies. Methods in molecular biology (Clifton, N.J.) 2013. PMID: 23975793


  20. Li Y, Taketo T, Lau YF. Isolation of fetal gonads from embryos of timed-pregnant mice for morphological and molecular studies. Methods in molecular biology (Clifton, N.J.) 2012. PMID: 22144232


  21. Kido T, Ou JH, Lau YF. The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the proteasome pathway. PloS one 2011. PMID: 21829568


  22. Kido T, Schubert S, Schmidtke J, Chris Lau YF. Expression of the human TSPY gene in the brains of transgenic mice suggests a potential role of this Y chromosome gene in neural functions. Journal of genetics and genomics = Yi chuan xue bao 2011. PMID: 21621739


  23. Lau YF, Li Y, Kido T. Role of the Y-located putative gonadoblastoma gene in human spermatogenesis. Systems biology in reproductive medicine 2011. PMID: 21204751


  24. Kido T, Hatakeyama S, Ohyama C, Lau YF. Expression of the Y-Encoded TSPY is Associated with Progression of Prostate Cancer. Genes 2010. PMID: 24710046


  25. Lee TL, Li Y, Cheung HH, Claus J, Singh S, Sastry C, Rennert OM, Lau YF, Chan WY. GonadSAGE: a comprehensive SAGE database for transcript discovery on male embryonic gonad development. Bioinformatics (Oxford, England) 2009. PMID: 20028690


  26. Peng H, Ivanov AV, Oh HJ, Lau YF, Rauscher FJ. Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery. The Journal of biological chemistry 2009. PMID: 19850934


  27. Wu JB, Chen K, Li Y, Lau YF, Shih JC. Regulation of monoamine oxidase A by the SRY gene on the Y chromosome. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009. PMID: 19661285


  28. Lee TL, Li Y, Alba D, Vong QP, Wu SM, Baxendale V, Rennert OM, Lau YF, Chan WY. Developmental staging of male murine embryonic gonad by SAGE analysis. Journal of genetics and genomics = Yi chuan xue bao 2009. PMID: 19376482


  29. Lau YF, Li Y. The human and mouse sex-determining SRY genes repress the Rspol/beta-catenin signaling. Journal of genetics and genomics = Yi chuan xue bao 2009. PMID: 19376480


  30. Lau YF, Li Y, Kido T. Gonadoblastoma locus and the TSPY gene on the human Y chromosome. Birth defects research. Part C, Embryo today : reviews 2009. PMID: 19306348


  31. Dell'Orco D. Fast predictions of thermodynamics and kinetics of protein-protein recognition from structures: from molecular design to systems biology. Molecular bioSystems 2009. PMID: 19396368


  32. Li Y, Kido T, Luo J, Fukuda M, Dobrinski I, Lau YF. Intratubular transplantation as a strategy for establishing animal models of testicular germ cell tumours. International journal of experimental pathology 2008. PMID: 18808526


  33. Kido T, Lau YF. The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein. International journal of cancer 2008. PMID: 18649364


  34. Li Y, Lau YF. TSPY and its X-encoded homologue interact with cyclin B but exert contrasting functions on cyclin-dependent kinase 1 activities. Oncogene 2008. PMID: 18591933


  35. Oh HJ, Kido T, Lau YF. PIAS1 interacts with and represses SOX9 transactivation activity. Molecular reproduction and development 2007. PMID: 17440973


  36. de Jong J, Stoop H, Gillis AJ, van Gurp RJ, van Drunen E, Beverloo HB, Lau YF, Schneider DT, Sherlock JK, Baeten J, Hatakeyama S, Ohyama C, Oosterhuis JW, Looijenga LH. JKT-1 is not a human seminoma cell line. International journal of andrology 2007. PMID: 17705808


  37. Cools M, Boter M, van Gurp R, Stoop H, Poddighe P, Lau YF, Drop SL, Wolffenbuttel KP, Looijenga LH. Impact of the Y-containing cell line on histological differentiation patterns in dysgenetic gonads. Clinical endocrinology 2007. PMID: 17547684


  38. LAU YFC
    CHAN WY. Y Chromosome and Male Germ Cell Biology in Health and Diseases Y Chromosome and Male Germ Cell Biology in Health and Diseases 2007. PMID:


  39. Li Y, Tabatabai ZL, Lee TL, Hatakeyama S, Ohyama C, Chan WY, Looijenga LH, Lau YF. The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors. Human pathology 2007. PMID: 17521702


  40. Li Y, Vilain E, Conte F, Rajpert-De Meyts E, Lau YF. Testis-specific protein Y-encoded gene is expressed in early and late stages of gonadoblastoma and testicular carcinoma in situ. Urologic oncology 2007. PMID: 17349529


  41. Kido T, Lau YF. The rat Tspy is preferentially expressed in elongated spermatids and interacts with the core histones. Biochemical and biophysical research communications 2006. PMID: 16996029


  42. Li Y, Oh HJ, Lau YF. The poly(ADP-ribose) polymerase 1 interacts with Sry and modulates its biological functions. Molecular and cellular endocrinology 2006. PMID: 16904257


  43. Oram SW, Liu XX, Lee TL, Chan WY, Lau YF. TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells. BMC cancer 2006. PMID: 16762081


  44. Vong QP, Li Y, Lau YF, Dym M, Rennert OM, Chan WY. Structural characterization and expression studies of Dby and its homologs in the mouse. Journal of andrology 2006. PMID: 16728723


  45. Hoei-Hansen CE, Sehested A, Juhler M, Lau YF, Skakkebaek NE, Laursen H, Rajpert-de Meyts E. New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers. The Journal of pathology 2006. PMID: 16456896


  46. Honecker F, Stoop H, Mayer F, Bokemeyer C, Castrillon DH, Lau YF, Looijenga LH, Oosterhuis JW. Germ cell lineage differentiation in non-seminomatous germ cell tumours. The Journal of pathology 2006. PMID: 16273510


  47. Oh HJ, Lau YF. KRAB: a partner for SRY action on chromatin. Molecular and cellular endocrinology 2006. PMID: 16414182


  48. Cools M, Honecker F, Stoop H, Veltman JD, de Krijger RR, Steyerberg E, Wolffenbuttel KP, Bokemeyer C, Lau YF, Drop SL, Looijenga LH. Maturation delay of germ cells in fetuses with trisomy 21 results in increased risk for the development of testicular germ cell tumors. Human pathology 2006. PMID: 16360422


  49. Kido T, Lau YF. A Cre gene directed by a human TSPY promoter is specific for germ cells and neurons. Genesis (New York, N.Y. : 2000) 2005. PMID: 16035036


  50. Taketo T, Lee CH, Zhang J, Li Y, Lee CY, Lau YF. Expression of SRY proteins in both normal and sex-reversed XY fetal mouse gonads. Developmental dynamics : an official publication of the American Association of Anatomists 2005. PMID: 15789443


  51. Williams K, Fernandez S, Stien X, Ishii K, Love HD, Lau YF, Roberts RL, Hayward SW. Unopposed c-MYC expression in benign prostatic epithelium causes a cancer phenotype. The Prostate 2005. PMID: 15937962


  52. Kersemaekers AM, Honecker F, Stoop H, Cools M, Molier M, Wolffenbuttel K, Bokemeyer C, Li Y, Lau YF, Oosterhuis JW, Looijenga LH. Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY. Human pathology 2005. PMID: 15948118


  53. Oh HJ, Li Y, Lau YF. Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein. Biology of reproduction 2004. PMID: 15469996


  54. Lau YF, Lau HW, Kömüves LG. Expression pattern of a gonadoblastoma candidate gene suggests a role of the Y chromosome in prostate cancer. Cytogenetic and genome research 2003. PMID: 14684991


  55. Li Y, Yue L, Taketo T, Lau YF. Protein transduction as a strategy for evaluating important factors in mammalian sex determination and differentiation. Cytogenetic and genome research 2003. PMID: 14684989


  56. Liu WS, Nordqvist K, Lau YF, Fredga K. Characterization of the Xp21-23 region in the wood lemming, a region involved in XY sex reversal. The Journal of experimental zoology 2001. PMID: 11748603


  57. Xian M, Zhang J, Lau YF. Sry promoters from domesticus (Tirano) and C57BL/6 mice function similarly in embryos and adult animals. The Journal of experimental zoology 2001. PMID: 11748612


  58. Kren V, Qi N, Krenova D, Zidek V, Sladká M, Jáchymová M, Míková B, Horky K, Bonne A, Van Lith HA, Van Zutphen BF, Lau YF, Pravenec M, St Lezin E. Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR. Hypertension (Dallas, Tex. : 1979) 2001. PMID: 11304517


  59. Karliner JS, Honbo N, Epstein CJ, Xian M, Lau YF, Gray MO. Neonatal mouse cardiac myocytes exhibit cardioprotection induced by hypoxic and pharmacologic preconditioning and by transgenic overexpression of human Cu/Zn superoxide dismutase. Journal of molecular and cellular cardiology 2000. PMID: 11013122


  60. Lau YF, Zhang J. Expression analysis of thirty one Y chromosome genes in human prostate cancer. Molecular carcinogenesis 2000. PMID: 10747295


  61. Xian M, Honbo N, Zhang J, Liew CC, Karliner JS, Lau YF. The green fluorescent protein is an efficient biological marker for cardiac myocytes. Journal of molecular and cellular cardiology 1999. PMID: 10640443


  62. Zhang J, Coward P, Xian M, Lau YF. In vitro binding and expression studies demonstrate a role for the mouse Sry Q-rich domain in sex determination. The International journal of developmental biology 1999. PMID: 10410901


  63. Lau YF. Gonadoblastoma, testicular and prostate cancers, and the TSPY gene. American journal of human genetics 1999. PMID: 10090875


  64. Diatchenko L, Lukyanov S, Lau YF, Siebert PD. Suppression subtractive hybridization: a versatile method for identifying differentially expressed genes. Methods in enzymology 1999. PMID: 10349654


  65. Lau YF, Zhang J. Sry interactive proteins: implication for the mechanisms of sex determination. Cytogenetics and cell genetics 1998. PMID: 9678346


  66. Shimamura R, Fraizer GC, Trapman J, Saunders GF. The Wilms' tumor gene WT1 can regulate genes involved in sex determination and differentiation: SRY, Müllerian-inhibiting substance, and the androgen receptor. Clinical cancer research : an official journal of the American Association for Cancer Research 1997. PMID: 9815658


  67. Liou JD, Ma YY, Gibson LH, Su H, Charest N, Lau YF, Yang-Feng TL. Cytogenetic and molecular studies of a familial paracentric inversion of Y chromosome present in a patient with ambiguous genitalia. American journal of medical genetics 1997. PMID: 9128931


  68. Vogt PH, Affara N, Davey P, Hammer M, Jobling MA, Lau YF, Mitchell M, Schempp W, Tyler-Smith C, Williams G, Yen P, Rappold GA. Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997. Cytogenetics and cell genetics 1997. PMID: 9533010


  69. Diatchenko L, Lau YF, Campbell AP, Chenchik A, Moqadam F, Huang B, Lukyanov S, Lukyanov K, Gurskaya N, Sverdlov ED, Siebert PD. Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries. Proceedings of the National Academy of Sciences of the United States of America 1996. PMID: 8650213


  70. Affara N, Bishop C, Brown W, Cooke H, Davey P, Ellis N, Graves JM, Jones M, Mitchell M, Rappold G, Tyler-Smith C, Yen P, Lau YF. Report of the Second International Workshop on Y Chromosome Mapping 1995. Cytogenetics and cell genetics 1996. PMID: 8646888


  71. Dubin RA, Coward P, Lau YF, Ostrer H. Functional comparison of the Mus musculus molossinus and Mus musculus domesticus Sry genes. Molecular endocrinology (Baltimore, Md.) 1995. PMID: 8614401


  72. Coward P, Nagai K, Chen D, Thomas HD, Nagamine CM, Lau YF. Polymorphism of a CAG trinucleotide repeat within Sry correlates with B6.YDom sex reversal. Nature genetics 1994. PMID: 8012385


  73. Affara NA, Lau YF, Briggs H, Davey P, Jones MH, Khwaja O, Mitchell M, Sargent C. Report and abstracts of the First International Workshop on Y Chromosome Mapping 1994. Cambridge, England, April 2-5, 1994. Cytogenetics and cell genetics 1994. PMID: 7924456


  74. Boissonneault G, Lau YF. A testis-specific gene encoding a nuclear high-mobility-group box protein located in elongating spermatids. Molecular and cellular biology 1993. PMID: 8321234


  75. Su H, Lau YF. Identification of the transcriptional unit, structural organization, and promoter sequence of the human sex-determining region Y (SRY) gene, using a reverse genetic approach. American journal of human genetics 1993. PMID: 8434602


  76. Zhang JS, Yang-Feng TL, Muller U, Mohandas TK, de Jong PJ, Lau YF. Molecular isolation and characterization of an expressed gene from the human Y chromosome. Human molecular genetics 1992. PMID: 1284595


  77. Su H, Lau YF. Demonstration of a stage-specific expression of the ZFY protein in fetal mouse testis using anti-peptide antibodies. Molecular reproduction and development 1992. PMID: 1449792


  78. Su H, Kozak CA, Veerhuis R, Lau YF, Wiberg U. Isolation of a phylogenetically conserved and testis-specific gene using a monoclonal antibody against the serological H-Y antigen. Journal of reproductive immunology 1992. PMID: 1522559


  79. Nagamine CM, Nishioka Y, Moriwaki K, Boursot P, Bonhomme F, Lau YF. The musculus-type Y chromosome of the laboratory mouse is of Asian origin. Mammalian genome : official journal of the International Mammalian Genome Society 1992. PMID: 1352158


  80. Lau YF, Yang-Feng TL, Elder B, Fredga K, Wiberg UH. Unusual distribution of Zfy and Zfx sequences on the sex chromosomes of the wood lemming, a species exhibiting XY sex reversal. Cytogenetics and cell genetics 1992. PMID: 1349859


  81. . American Academy of Pediatrics Committee on Drugs: Prescription drug advertising direct to the consumer. Pediatrics 1991. PMID: 2057258


  82. Liu MS, Chan KM, Lau YF, Lee CY. Molecular cloning of an acrosomal sperm antigen gene and the production of its recombinant protein for immunocontraceptive vaccine. Molecular reproduction and development 1990. PMID: 2331378


  83. Leung WY, Lindgren V, Lau YF, Yang-Feng YL. Regional assignments of the zinc finger Y-linked gene (ZFY) and related sequences on human and mouse chromosomes. Cytogenetics and cell genetics 1990. PMID: 2265557


  84. Jen J, Deschepper CF, Shackleford GM, Lee CY, Lau YF. Stage-specific expression of the lactate dehydrogenase-X gene in adult and developing mouse testes. Molecular reproduction and development 1990. PMID: 2393579


  85. Nagamine CM, Chan K, Hake LE, Lau YF. The two candidate testis-determining Y genes (Zfy-1 and Zfy-2) are differentially expressed in fetal and adult mouse tissues. Genes & development 1990. PMID: 1968414


  86. Lau YF, Chan KM. The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues. American journal of human genetics 1989. PMID: 2511751


  87. Lau YF, Chan KM, Sparkes R. Male-enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis. Proceedings of the National Academy of Sciences of the United States of America 1989. PMID: 2813404


  88. Nagamine CM, Chan K, Lau YF. A PCR artifact: generation of heteroduplexes. American journal of human genetics 1989. PMID: 2631699


  89. Poole SJ, Law ML, Kao FT, Lau YF. Isolation and chromosomal localization of the human En-2 gene. Genomics 1989. PMID: 2565873


  90. Nagamine CM, Chan KM, Kozak CA, Lau YF. Chromosome mapping and expression of a putative testis-determining gene in mouse. Science (New York, N.Y.) 1989. PMID: 2563174


  91. Gross MS, Sefiani A, de Tand MF, Lau YF, Saidi-Mehtar N, Hors-Cayla MC, Frezal J, Van Cong N. The anonymous PAS45 probe detects RFLPs in 13q31. Annales de genetique 1989. PMID: 2569289


  92. Kao FT, Wu KC, Law ML, Hartz JA, Lau YF. Assignment of human gene encoding testis-specific lactate dehydrogenase C to chromosome 11, region p14.3-p15.5. Somatic cell and molecular genetics 1988. PMID: 3175768


  93. LAU YF. Endocrine Genes: Analytical Methods, Experimental Approaches and Selected Systems Endocrine Genes: Analytical Methods, Experimental Approaches and Selected Systems 1988. PMID:


  94. Kim YK, Wells S, Lau YF, Lee AS. Sequences contained within the promoter of the human thymidine kinase gene can direct cell-cycle regulation of heterologous fusion genes. Proceedings of the National Academy of Sciences of the United States of America 1988. PMID: 3413063


  95. Tagawa M, Ito T, Kanno M, Okitsu A, Sakamoto T, Imai K, Kuwabara I, Koseki H, Matsubara H, Lau YF. Method of genomic DNA cloning by the combination of cosmid shuttle vector and monoclonal antibody. Microbiology and immunology 1988. PMID: 3231129


  96. Bray PF, Rosa JP, Johnston GI, Shiu DT, Cook RG, Lau C, Kan YW, McEver RP, Shuman MA. Platelet glycoprotein IIb. Chromosomal localization and tissue expression. The Journal of clinical investigation 1987. PMID: 3479442


  97. Boer PH, Adra CN, Lau YF, McBurney MW. The testis-specific phosphoglycerate kinase gene pgk-2 is a recruited retroposon. Molecular and cellular biology 1987. PMID: 2823118


  98. Wu KC, Chan K, Lee CY, Lau YF. Molecular isolation and sequence determination of the cDNA for the mouse sperm-specific lactate dehydrogenase-X gene. Biochemical and biophysical research communications 1987. PMID: 3619944


  99. Manavathu EK, Suryanarayana K, Hasnain SE, Leung M, Lau YF, Leung WC. Expression of herpes simplex virus thymidine kinase gene in aquatic filamentous fungus Achlya ambisexualis. Gene 1987. PMID: 2828182


  100. Lau YF, Chan KM, Kan YW, Goldberg E. Male-enhanced expression and genetic conservation of a gene isolated with an anti-H-Y antibody. Transactions of the Association of American Physicians 1987. PMID: 3455075


  101. Reardon CA, Lau YF, Paik YK, Weisgraber KH, Mahley RW, Taylor JM. Expression of the human apolipoprotein E gene in cultured mammalian cells. The Journal of biological chemistry 1986. PMID: 3733697


  102. Reardon CA, Paik YK, Chang DJ, Davies GE, Mahley RW, Lau YF, Taylor JM. Cloning and expression of the human apolipoprotein E gene. Methods in enzymology 1986. PMID: 3014273


  103. Choo KH, Filby G, Greco S, Lau YF, Kan YW. Cosmid vectors for high efficiency DNA-mediated transformation and gene amplification in mammalian cells: studies with the human growth hormone gene. Gene 1986. PMID: 3468045


  104. Lebo RV, Anderson LA, Lau YF, Flandermeyer R, Kan YW. Flow-sorting analysis of normal and abnormal human genomes. Cold Spring Harbor symposia on quantitative biology 1986. PMID: 3472713


  105. Lau YF, Ying KL, Donnell GN. Identification of a case of Y:18 translocation using a Y-specific repetitive DNA probe. Human genetics 1985. PMID: 2982722


  106. Lau YF, Schonberg S. A male-specific DNA probe detects heterochromatin sequences in a familial Yq- chromosome. American journal of human genetics 1984. PMID: 6517059


  107. Lau YF, Lin CC, Kan YW. Amplification and expression of human alpha-globin genes in Chinese hamster ovary cells. Molecular and cellular biology 1984. PMID: 6493227


  108. Lau YF, Huang JC, Dozy AM, Kan YW. A rapid screening test for antenatal sex determination. Lancet (London, England) 1984. PMID: 6140342


  109. Lau YF, Kan YW. Direct isolation of the functional human thymidine kinase gene with a cosmid shuttle vector. Proceedings of the National Academy of Sciences of the United States of America 1984. PMID: 6320187


  110. Lau YF, Kan YW. Versatile cosmid vectors for the isolation, expression, and rescue of gene sequences: studies with the human alpha-globin gene cluster. Proceedings of the National Academy of Sciences of the United States of America 1983. PMID: 6310566


  111. Lau YF, Lin CC, Kan YW. Amplification of the human alpha-globin gene enhances its expression. Transactions of the Association of American Physicians 1983. PMID: 6679967


  112. Lau YF, Arrighi FE. Studies of mammalian chromosome replication. II. Evidence for the existence of defined chromosome replicating units. Chromosoma 1981. PMID: 7028418


  113. Hubbell HR, Lau YF, Brown RL, Hsu TC. Cell cycle analysis and drug inhibition studies of silver staining in synchronous HeLa cells. Experimental cell research 1980. PMID: 6159216


  114. Arrighi FE, Lau YF, Spallone A. Nucleolar activity in differentiated cells after stimulation. Cytogenetics and cell genetics 1980. PMID: 6156056


  115. Lau YF, Arrighi FE. Studies of mammalian chromosome replication. I. BrdU-induced differential staining patterns in interphase and metaphase chromosomes. Cytogenetics and cell genetics 1980. PMID: 6156800


  116. Lau YF, Wertelecki W, Pfeiffer RA, Arrighi FE. Cytological analyses of 14p+ variant by means of N-banding and combinations of silver staining and chromosome bandings. Human genetics 1979. PMID: 85597


  117. Lau YF, Pfeiffer RA, Arrighi FE, Hsu TC. Combination of silver and fluorescent staining for metaphase chromosomes. American journal of human genetics 1978. PMID: 74950


  118. Lau YF, Brown RL, Arrighi FE. Induction of premature chromosome condensation in CHO cells fused with polyethylene glycol. Experimental cell research 1977. PMID: 923665


  119. Lau YF, Arrighi FE, Chuang CR. Studies of the squirel monkey, Saimiri sciureus, genome. II. C-band characterization and DNA replication patterns. Cytogenetics and cell genetics 1977. PMID: 408102


  120. Lau YF, Hsu TC. Variable modes of Robertsonian fusions. Cytogenetics and cell genetics 1977. PMID: 74307


  121. Lau YF, Hittelman WN, Arrighi FE. Sister chromatid differential staining pattern in prematurely condensed chromosomes. Experientia 1976. PMID: 954984


  122. Lau YF, Arrighi FE. Studies of the squirrel monkey, Saimiri sciureus, genome. I. Cytological characterization of chromosomal heterozygosity. Cytogenetics and cell genetics 1976. PMID: 820523