Christine Hsieh, PhD

Assistant Professor

Dr. Christine Hsieh is a cellular neuroimmunologist focused on understanding mechanisms of inflammation that contribute to diseases with an urgent need for therapies, such as lupus, frontotemporal dementia (FTD) and traumatic brain injury (TBI). Her research has largely focused on the roles of innate immune receptors expressed by macrophages, microglia, B cells, and/or NK cells in disease, and how receptor activity can be modulated for therapy.

Education
Postdoctoral Fellowship, 2010 - Department of Medicine, Rheumatology Division, University of California, San Francisco
Ph.D., 2006 - School of Medicine, Immunology Program, Stanford University
B.S., 1999 - Molecular, Cell and Developmental Biology, University of California, Los Angeles
Honors and Awards
  • Innovation Award, Curia Biologics, 2022
  • Career Development Award-2, VA Biomedical Laboratory Research & Development, 2011-2015
  • NIH Ruth L. Kirschstein National Research Service Award, NIH National Institute of Neurological Disorders and Stroke, 2007-2009
  • B.S. with Magna Cum Laude Honors and College Honors, University of California, Los Angeles, 1999
Websites
Publications

  1. Omodaka S, Kato Y, Sato Y, Falcone-Juengert J, Zhang H, Kanoke A, Eckalbar WL, Endo H, Hsieh CL, Aran D, Liu J. Defective interferon signaling in the circulating monocytes of type 2 diabetic mice. bioRxiv : the preprint server for biology 2024. PMID: 38895236


  2. Clark D, Brazina S, Miclau T, Park S, Hsieh CL, Nakamura M, Marcucio R. Age-related changes to macrophage subpopulations and TREM2 dysregulation characterize attenuated fracture healing in old mice. Aging cell 2024. PMID: 38825965


  3. Somebang K, Rudolph J, Imhof I, Li L, Niemi EC, Shigenaga J, Tran H, Gill TM, Lo I, Zabel BA, Schmajuk G, Wipke BT, Gyoneva S, Jandreski L, Craft M, Benedetto G, Plowey ED, Charo I, Campbell J, Ye CJ, Panter SS, Nakamura MC, Eckalbar W, Hsieh CL. CCR2 deficiency alters activation of microglia subsets in traumatic brain injury. Cell reports 2021. PMID: 34551293


  4. Kanoke A, Nishijima Y, Ljungberg M, Omodaka S, Yang SY, Wong S, Rabiller G, Tominaga T, Hsieh CL, Liu J. The effect of type 2 diabetes on CD36 expression and the uptake of oxLDL: Diabetes affects CD36 and oxLDL uptake. Experimental neurology 2020. PMID: 32926860


  5. Clark D, Brazina S, Yang F, Hu D, Hsieh CL, Niemi EC, Miclau T, Nakamura MC, Marcucio R. Age-related changes to macrophages are detrimental to fracture healing in mice. Aging cell 2020. PMID: 32096907


  6. Telwatte S, Morón-López S, Aran D, Kim P, Hsieh C, Joshi S, Montano M, Greene WC, Butte AJ, Wong JK, Yukl SA. Heterogeneity in HIV and cellular transcription profiles in cell line models of latent and productive infection: implications for HIV latency. Retrovirology 2019. PMID: 31711503


  7. Boza-Serrano A, Ruiz R, Sanchez-Varo R, García-Revilla J, Yang Y, Jimenez-Ferrer I, Paulus A, Wennström M, Vilalta A, Allendorf D, Davila JC, Stegmayr J, Jiménez S, Roca-Ceballos MA, Navarro-Garrido V, Swanberg M, Hsieh CL, Real LM, Englund E, Linse S, Leffler H, Nilsson UJ, Brown GC, Gutierrez A, Vitorica J, Venero JL, Deierborg T. Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease. Acta neuropathologica 2019. PMID: 31006066


  8. Kurisu K, Zheng Z, Kim JY, Shi J, Kanoke A, Liu J, Hsieh CL, Yenari MA. Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2018. PMID: 30523715


  9. . ADAM17 Is The Main Sheddase For The Generation Of Human Triggering Receptor Expressed In Myeloid Cells (hTREM2) Ectodomain And Cleaves TREM2 After Histidine 157. 2017. PMID:


  10. Bucay N, Sekhon K, Yang T, Majid S, Shahryari V, Hsieh C, Mitsui Y, Deng G, Tabatabai ZL, Yamamura S, Calin GA, Dahiya R, Tanaka Y, Saini S. MicroRNA-383 located in frequently deleted chromosomal locus 8p22 regulates CD44 in prostate cancer. Volume 36 of Issue 19. Oncogene 2016. PMID: 27893706


  11. Kim CC, Nakamura MC, Hsieh CL. Brain trauma elicits non-canonical macrophage activation states. Volume 13 of Issue 1. Journal of neuroinflammation 2016. PMID: 27220367


  12. Lui H, Zhang J, Makinson SR, Cahill MK, Kelley KW, Huang HY, Shang Y, Oldham MC, Martens LH, Gao F, Coppola G, Sloan SA, Hsieh CL, Kim CC, Bigio EH, Weintraub S, Mesulam MM, Rademakers R, Mackenzie IR, Seeley WW, Karydas A, Miller BL, Borroni B, Ghidoni R, Farese RV, Paz JT, Barres BA, Huang EJ. Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation. Volume 165 of Issue 4. Cell 2016. PMID: 27114033


  13. Kawabori M, Kacimi R, Kauppinen T, Calosing C, Kim JY, Hsieh CL, Nakamura MC, Yenari MA. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. Volume 35 of Issue 8. The Journal of neuroscience : the official journal of the Society for Neuroscience 2015. PMID: 25716838


  14. Hsieh CL, Niemi EC, Wang SH, Lee CC, Bingham D, Zhang J, Cozen ML, Charo I, Huang EJ, Liu J, Nakamura MC. CCR2 deficiency impairs macrophage infiltration and improves cognitive function after traumatic brain injury. Volume 31 of Issue 20. Journal of neurotrauma 2014. PMID: 24806994


  15. Kawabori M, Hokari M, Zheng Z, Kim JY, Calosing C, Hsieh CL, Nakamura MC, Yenari MA. Triggering Receptor Expressed on Myeloid Cells-2 Correlates to Hypothermic Neuroprotection in Ischemic Stroke. Volume 3 of Issue 4. Therapeutic hypothermia and temperature management 2013. PMID: 24380032


  16. Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE. Traumatic brain injury induces macrophage subsets in the brain. Volume 43 of Issue 8. European journal of immunology 2013. PMID: 23630120


  17. Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, Nakamura MC, Seaman WE. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. Volume 109 of Issue 4. Journal of neurochemistry 2009. PMID: 19302484


  18. Hsieh CL, Nagasaki K, Martinez OM, Krams SM. NKp30 is a functional activation receptor on a subset of rat natural killer cells. Volume 36 of Issue 8. European journal of immunology 2006. PMID: 16821237


  19. Obara H, Nagasaki K, Hsieh CL, Ogura Y, Esquivel CO, Martinez OM, Krams SM. IFN-gamma, produced by NK cells that infiltrate liver allografts early after transplantation, links the innate and adaptive immune responses. Volume 5 of Issue 9. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005. PMID: 16095488


  20. Hsieh CL, Ogura Y, Obara H, Ali UA, Rodriguez GM, Nepomuceno RR, Martinez OM, Krams SM. Identification, cloning, and characterization of a novel rat natural killer receptor, RNKP30: a molecule expressed in liver allografts. Volume 77 of Issue 1. Transplantation 2004. PMID: 14724446


  21. Land KM, Delgadillo-Correa MG, Tachezy J, Vanacova S, Hsieh CL, Sutak R, Johnson PJ. Targeted gene replacement of a ferredoxin gene in Trichomonas vaginalis does not lead to metronidazole resistance. Volume 51 of Issue 1. Molecular microbiology 2004. PMID: 14651615


  22. Bradley PJ, Hsieh CL, Boothroyd JC. Unprocessed Toxoplasma ROP1 is effectively targeted and secreted into the nascent parasitophorous vacuole. Volume 125 of Issue 1-2. Molecular and biochemical parasitology 2002. PMID: 12467986


  23. Hsieh CL, Obara H, Ogura Y, Martinez OM, Krams SM. NK cells and transplantation. Volume 9 of Issue 2-4. Transplant immunology 2002. PMID: 12180816