David Lovett, MD

Professor in Residence

Education:
A.B. Indiana University, Zoology and Chemistry, Highest Distinction
M.D. Indiana University, Highest Distinction
Resident in Internal Medicine, Yale University
Chief Resident in Internal Medicine, Yale University
Fellow in Nephrology, Yale University
Fellow, Alexander von Humboldt Stiftung, Medizinische Hochschule Hannover Germany

Clinical and Academic Activities:
Professor of Medicine in Residence, Step 9, emeritus 2020
Chief, Nephrology Section SFVAMC, 1995-2019

University/Public Service:
Principal Investigator UCSF T32 Academic Training Program in Nephrology 2006-2016
Member, UCSF Committee on Academic Personnel 2016-2017
Vice Chair, UCSF Committee on Academic Personnel 2017-2018
Chair, UCSF Committee on Academic Personnel 2018-2019

Scholarly Activity: Our laboratory has primarily focused in recent years on an examination of the role of matrix metalloproteinase 2 in progressive cardiac and renal failure. These studies have included determinations of transcriptional regulatory networks, impact of promoter haplotypes on gene expression and generation of a series of transgenic mice to directly test the significance of MMP-2 expression on renal and cardiac disease. We have demonstrated that MMP-2 alone is sufficient to trigger the entire process of progressive renal disease seen in humans, including glomerulosclerosis, tubular atrophy and interstitial fibrosis without the requirement for superimposed injury. In the heart we have published a series of studies demonstrating that MMP-2 directly mediates cardiomyocyte apoptosis and contractile failure. More recently we have characterized (Lovett, et al., PLoS One 2012) a novel intracelllular isoform of MMP-2 that activates innate immunity. The isoform is generated by oxidative stress mediated activation of an alternative promoter in the first intron of the MMP-2 gene, thereby generating an intracellular, active N-terminal truncated enzyme. Transgenic mice expressing this isoform in the heart develop severe cardiomyocyte hypertrophy, inflammation and sytolic failure. Transgenic mice expressing this isoform in the kidney develop progressive tubular atrophy due mitochondrial damage mediated regulated necrosis. We are currently determining the extent of expression of this MMP-2 isoform in clinical specimens of cardiac and renal tissue using a combination of histochemical and epigenetic approaches. In addition, we are studying the epigenetic regulation of the MMP-2 intronic promoter using a novel series of transgenic reporter mice and epigenetic techniques. We believe that both isoforms of MMP-2 represent appealing therapeutic targets and we are currently developing antibody and siRNA-based strategies to selectively inhibit the MMP-2 isoforms in models of cardiac and renal disease.

Honors and Awards
  • American Society of Clinical Investigation
Publications

  1. Spaulding KA, Zhu Y, Takaba K, Ramasubramanian A, Badathala A, Haraldsson H, Collins A, Aguayo E, Shah C, Wallace AW, Ziats NP, Lovett DH, Baker AJ, Healy KE, Ratcliffe MB. Myocardial injection of a thermoresponsive hydrogel with reactive oxygen species scavenger properties improves border zone contractility. Journal of biomedical materials research. Part A 2020. PMID: 32270584


  2. Grubbs V, Garcia F, Vittinghoff E, Jue BL, Ryder M, Lovett DH, Offenbacher S, Taylor G, Ganz P, Bibbins-Domingo K, Powe NR. Nonsurgical Periodontal Therapy in CKD: Findings of the Kidney and Periodontal Disease (KAPD) Pilot Randomized Controlled Trial. Kidney Medicine 2019. PMID: 32734226


  3. Lee HW, Lee SJ, Lee MY, Park MW, Kim SS, Shin N, Lovett DH, Bae SS, Ahn J, Park JS, Oh JH, Choi JH, Lee HC, Cha KS, Hong TJ, Song SH. Enhanced cardiac expression of two isoforms of matrix metalloproteinase-2 in experimental diabetes mellitus. PloS one 2019. PMID: 31461499


  4. Q. Zhang, S.K. Joshi, D.H. Lovett, G. Manzano, H.T. Kim, X. Liu. Muscle extracellular matrix degradation and contractibility following tendon rupture and disuse. Muscles Ligaments and Tendons Journal 2019. PMID:


  5. Cowley PM, Wang G, Swigart PM, Raghunathan A, Reddy NP, Dulam P, Lovett DH, Simpson PC, Baker AJ. Reversal of Right Ventricular failure by Chronic α1A-Subtype Adrenergic Agonist Therapy. American journal of physiology. Heart and circulatory physiology 2018. PMID: 30412439


  6. Rhee H, Han M, Kim SS, Kim IY, Lee HW, Bae SS, Ha HK, Jung ES, Lee MY, Seong EY, Lee DW, Lee SB, Lovett DH, Song SH. The expression of two isoforms of matrix metalloproteinase-2 in aged mouse models of diabetes mellitus and chronic kidney disease. Kidney research and clinical practice 2018. PMID: 30254846


  7. Kim IY, Kim SS, Lee HW, Bae SS, Ha HK, Jung ES, Lee MY, Han M, Rhee H, Seong EY, Lee DW, Lee SB, Lovett DH, Song SH. The two isoforms of matrix metalloproteinase- 2 have distinct renal spatial and temporal distributions in murine models of types 1 and 2 diabetes mellitus. BMC nephrology 2018. PMID: 30253743


  8. Spaulding K, Takaba K, Collins A, Faraji F, Wang G, Aguayo E, Ge L, Saloner D, Wallace AW, Baker AJ, Lovett DH, Ratcliffe MB. Short term doxycycline treatment induces sustained improvement in myocardial infarction border zone contractility. PloS one 2018. PMID: 29432443


  9. Cowley PM, Wang G, Joshi S, Swigart PM, Lovett DH, Simpson PC, Baker AJ. a1A-Subtype adrenergic agonist therapy for the failing right ventricle. Volume 313 of Issue 6. American journal of physiology. Heart and circulatory physiology 2017. PMID: 28822963


  10. Baligand C, Qin H, True-Yasaki A, Gordon JW, von Morze C, Santos JD, Wilson DM, Raffai R, Cowley PM, Baker AJ, Kurhanewicz J, Lovett DH, Wang ZJ. Hyperpolarized 13 C magnetic resonance evaluation of renal ischemia reperfusion injury in a murine model. Volume 30 of Issue 10. NMR in biomedicine 2017. PMID: 28708304


  11. Landolt L, Eikrem Ø, Strauss P, Scherer A, Lovett DH, Beisland C, Finne K, Osman T, Ibrahim MM, Gausdal G, Ahmed L, Lorens JB, Thiery JP, Tan TZ, Sekulic M, Marti HP. Clear Cell Renal Cell Carcinoma is linked to Epithelial-to-Mesenchymal Transition and to Fibrosis. Volume 5 of Issue 11. Physiological reports 2017. PMID: 28596300


  12. Sang Heon Song, Harin Rhee, Il Young Kim, Eun Young Seong, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak, Min Young Lee, Soo Young Bang, David H Lovett. MP501A SPATIAL DISTRIBUTION OF TWO ISOFORMS OF MATRIX METALLOPROTEINASE-2 IN DIABETIC KIDNEY ACCORDING TO THE TIME OF DIABETIC MILIEU. Nephrology,Dialysis and Transplantation 2017. PMID:


  13. Patrick M Cowley, Guanying Wang, Philip M Swigart, David H Lovett, Paul C Simpson, Anthony J Baker. a1A-Subtype Adrenergic Agonist Therapy for Failing Right Ventricle. The FASEB Journal 2017. PMID:


  14. Ceron CS, Baligand C, Joshi S, Wanga S, Cowley PM, Walker JP, Song SH, Mahimkar R, Baker AJ, Raffai RL, Wang ZJ, Lovett DH. An intracellular matrix metalloproteinase-2 isoform induces tubular regulated necrosis: implications for acute kidney injury. Volume 312 of Issue 6. American journal of physiology. Renal physiology 2017. PMID: 28331061


  15. Kim SS, Shin N, Bae SS, Lee MY, Rhee H, Kim IY, Seong EY, Lee DW, Lee SB, Kwak IS, Lovett DH, Song SH. Enhanced expression of two discrete isoforms of matrix metalloproteinase-2 in experimental and human diabetic nephropathy. Volume 12 of Issue 2. PloS one 2017. PMID: 28178341


  16. Grubbs V, Garcia F, Jue BL, Vittinghoff E, Ryder M, Lovett D, Carrillo J, Offenbacher S, Ganz P, Bibbins-Domingo K, Powe NR. The Kidney and Periodontal Disease (KAPD) study: A pilot randomized controlled trial testing the effect of non-surgical periodontal therapy on chronic kidney disease. Volume 53. Contemporary clinical trials 2016. PMID: 28011387


  17. Patrick M Cowley, Guanying Wang, Sunil Joshi, David H Lovett, Paul C Simpson, Anthony J Baker. a1A-Subtype Adrenergic Therapy is Beneficial for Failing Right Ventricle (RV). The FASEB Journal 2016. PMID:


  18. Luk FS, Kim RY, Li K, Ching D, Wong DK, Joshi SK, Imhof I, Honbo N, Hoover H, Zhu BQ, Lovett DH, Karliner JS, Raffai RL. Immunosuppression With FTY720 Reverses Cardiac Dysfunction in Hypomorphic ApoE Mice Deficient in SR-BI Expression That Survive Myocardial Infarction Caused by Coronary Atherosclerosis. Volume 67 of Issue 1. Journal of cardiovascular pharmacology 2016. PMID: 26322923


  19. David H Lovett, Stanley Luk, Lalita Uttarwar, Sunil Joshi, Robert L RAffai. Abstract 17311: Molecular Memory and the Epigenetic Regulation of Cardiac Intracellular Matrix Metalloproteinase-2. Circulation 2015. PMID:


  20. Wanga S, Ceron CS, Delgado C, Joshi SK, Spaulding K, Walker JP, Song S, Olson JL, Lovett DH. Two Distinct Isoforms of Matrix Metalloproteinase-2 Are Associated with Human Delayed Kidney Graft Function. Volume 10 of Issue 9. PloS one 2015. PMID: 26379248


  21. Joshi SK, Lee L, Lovett DH, Kang H, Kim HT, Delgado C, Liu X. Novel intracellular N-terminal truncated matrix metalloproteinase-2 isoform in skeletal muscle ischemia-reperfusion injury. Volume 34 of Issue 3. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2015. PMID: 26213293


  22. Cowley PM, Wang G, Chang AN, Makwana O, Swigart PM, Lovett DH, Stull JT, Simpson PC, Baker AJ. The a1A-adrenergic receptor subtype mediates increased contraction of failing right ventricular myocardium. Volume 309 of Issue 5. American journal of physiology. Heart and circulatory physiology 2015. PMID: 26116709


  23. Marcos K. Lau, Joy L. Meier, Warren Gasper, David H. Lovett, Pauline M. Velez, Christopher D. Owens. RR15. Renal Progression in the Advanced Chronic Kidney Disease Populations: Creation of the ESRD Prediction Scorecard. Journal of vascular surgery 2015. PMID:


  24. Fu Sang Luk, Roy Y Kim, Kang Li, Daniel Ching, Sunil Joshi, Norman Honbo, Isabella Imhof, Bo-qing Zhu, David Lovett, Joel S Karliner, Robert L Raffai. Abstract 23: Immunosuppression with FTY720 Reverses Cardiac Dysfunction to Prevent Chronic Heart Failure in Mice that Survive Diet-induced Myocardial Infarction. 2015. PMID:


  25. Sangheon Song, Ihm Soo Kwak, Min Young Lee, Eun Young Seong, Harin Rhee, Il Young Kim, Dong Won Lee, Soo Bong Lee, David H Lovett. FP458THE EXPRESSION OF FULL LENGTH MMP-2 AND INTRACELLULAR N-TERMINAL TRUNCATED MMP-2 ISOFORM IN DIABETIC KIDNEY DISEASE. Nephrology,Dialysis and Transplantation 2015. PMID:


  26. Alam SG, Lovett D, Kim DI, Roux KJ, Dickinson RB, Lele TP. The nucleus is an intracellular propagator of tensile forces in NIH 3T3 fibroblasts. Volume 128 of Issue 10. Journal of cell science 2015. PMID: 25908852


  27. Zhang Q, Joshi SK, Lovett DH, Zhang B, Bodine S, Kim HT, Liu X. Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy. Volume 4 of Issue 4. Muscles, ligaments and tendons journal 2015. PMID: 25767782


  28. Patrick M. Cowley, Guanying Wang, Audrey N. Chang, David H. Lovett, James T. Stull, Paul C. Simpson, Anthony J. Baker. Upregulation of a1A-Subtype Adrenergic Signaling is Beneficial in Failing Right Ventricle (RV). Biophysical journal 2015. PMID:


  29. Ikizler TA, Lovett DH, Chertow GM, Mitch WE, Schiller B. Navigating toward research success in times of uncertainty: funding opportunities for early career investigators in nephrology. Volume 65 of Issue 3. American journal of kidney diseases : the official journal of the National Kidney Foundation 2014. PMID: 25542413


  30. Zhang Q, Joshi SK, Lovett DH, Zhang B, Bodine S, Kim H, Liu X. Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy. Volume 4 of Issue 3. Muscles, ligaments and tendons journal 2014. PMID: 25489556


  31. Lovett DH, Chu C, Wang G, Ratcliffe MB, Baker AJ. A N-terminal truncated intracellular isoform of matrix metalloproteinase-2 impairs contractility of mouse myocardium. Volume 5. Frontiers in physiology 2014. PMID: 25309453


  32. Shimkunas R, Makwana O, Spaulding K, Bazargan M, Khazalpour M, Takaba K, Soleimani M, Myagmar BE, Lovett DH, Simpson PC, Ratcliffe MB, Baker AJ. Myofilament dysfunction contributes to impaired myocardial contraction in the infarct border zone. Volume 307 of Issue 8. American journal of physiology. Heart and circulatory physiology 2014. PMID: 25128171


  33. Joy Walker, Robert Toy, Sean Thomas, Michael S Conte, Charles M Eichler, David Lovett, Warren J Gasper, Christopher D Owens. Abstract 363: Prolonged Upregulation of Proinflammatory and Profibrotic Genes is Characteristic of Successful Arteriovenous Fistula Maturation. Arteriosclerosis Thrombosis and Vascular Biology 2014. PMID:


  34. Walker JP, Hiramoto JS, Gasper WJ, Auyang P, Conte MS, Rapp JH, Lovett DH, Owens CD. Vitamin D deficiency is associated with mortality and adverse vascular access outcomes in patients with end-stage renal disease. Volume 60 of Issue 1. Journal of vascular surgery 2014. PMID: 24582700


  35. Lovett DH, Mahimkar R, Raffai RL, Cape L, Zhu BQ, Jin ZQ, Baker AJ, Karliner JS. N-terminal truncated intracellular matrix metalloproteinase-2 induces cardiomyocyte hypertrophy, inflammation and systolic heart failure. Volume 8 of Issue 7. PloS one 2013. PMID: 23874529


  36. Zhang Q, Joshi SK, Manzano G, Lovett DH, Kim HT, Liu X. Original article Muscle extracellular matrix degradation and contractibility following tendon rupture and disuse. Volume 3 of Issue 1. Muscles, ligaments and tendons journal 2013. PMID: 23885343


  37. Joy Walker, Jade S. Hiramoto, Philip Auyang, Hugh Alley, Michael Conte, David Lovett, Joseph Rapp, Christopher D. Owens. Vitamin D Deficiency Is Associated With Mortality and Adverse Vascular Access Outcomes in the ESRD Population. Journal of vascular surgery 2013. PMID:


  38. Chu C, Thai K, Park KW, Wang P, Makwana O, Lovett DH, Simpson PC, Baker AJ. Intraventricular and interventricular cellular heterogeneity of inotropic responses to a(1)-adrenergic stimulation. Volume 304 of Issue 7. American journal of physiology. Heart and circulatory physiology 2013. PMID: 23355341


  39. Joshi SK, Liu X, Samagh SP, Lovett DH, Bodine SC, Kim HT, Feeley BT. mTOR regulates fatty infiltration through SREBP-1 and PPAR? after a combined massive rotator cuff tear and suprascapular nerve injury in rats. Volume 31 of Issue 5. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2012. PMID: 23239524


  40. Chintala H, Liu H, Parmar R, Kamalska M, Kim YJ, Lovett D, Grant MB, Chaqour B. Connective tissue growth factor regulates retinal neovascularization through p53 protein-dependent transactivation of the matrix metalloproteinase (MMP)-2 gene. Volume 287 of Issue 48. The Journal of biological chemistry 2012. PMID: 23048035


  41. Lovett DH, Mahimkar R, Raffai RL, Cape L, Maklashina E, Cecchini G, Karliner JS. A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity. Volume 7 of Issue 4. PloS one 2012. PMID: 22509276


  42. Teerlink JR, Iragui VJ, Mohr JP, Carson PE, Hauptman PJ, Lovett DH, Miller AB, Piña IL, Thomson S, Varosy PD, Zile MR, Cleland JG, Givertz MM, Metra M, Ponikowski P, Voors AA, Davison BA, Cotter G, Wolko D, Delucca P, Salerno CM, Mansoor GA, Dittrich H, O'Connor CM, Massie BM. The safety of an adenosine A(1)-receptor antagonist, rolofylline, in patients with acute heart failure and renal impairment: findings from PROTECT. Volume 35 of Issue 3. Drug safety 2012. PMID: 22339573


  43. Liu X, Joshi SK, Samagh SP, Dang YX, Laron D, Lovett DH, Bodine SC, Kim HT, Feeley BT. Evaluation of Akt/mTOR activity in muscle atrophy after rotator cuff tears in a rat model. Volume 30 of Issue 9. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2012. PMID: 22378614


  44. David H Lovett, Rajeev Mahimkar, Elena Maklashina, Gary Cecchini, Joel S Karliner. Abstract 18433: A Novel Intracellular Isoform of Matrix Metalloproteinase-2 Activates Innate Immunity and Leads to Cardiac Failure. Circulation 2011. PMID:


  45. Mahimkar R, Alfonso-Jaume MA, Cape LM, Dahiya R, Lovett DH. Graded activation of the MEK1/MT1-MMP axis determines renal epithelial cell tumor phenotype. Volume 32 of Issue 12. Carcinogenesis 2011. PMID: 21965271


  46. Findeisen HM, Gizard F, Zhao Y, Cohn D, Heywood EB, Jones KL, Lovett DH, Howatt DA, Daugherty A, Bruemmer D. Telomerase deficiency in bone marrow-derived cells attenuates angiotensin II-induced abdominal aortic aneurysm formation. Volume 31 of Issue 2. Arteriosclerosis, thrombosis, and vascular biology 2010. PMID: 21088250


  47. Dahi S, Karliner JS, Sarkar R, Lovett DH. Transgenic expression of matrix metalloproteinase-2 induces coronary artery ectasia. Volume 92 of Issue 1. International journal of experimental pathology 2010. PMID: 21039989


  48. Lovett DH, Cheng S, Cape L, Pollock AS, Mertens PR. YB-1 alters MT1-MMP trafficking and stimulates MCF-7 breast tumor invasion and metastasis. Volume 398 of Issue 3. Biochemical and biophysical research communications 2010. PMID: 20599698


  49. Liu X, Manzano G, Lovett DH, Kim HT. Role of AP-1 and RE-1 binding sites in matrix metalloproteinase-2 transcriptional regulation in skeletal muscle atrophy. Volume 396 of Issue 2. Biochemical and biophysical research communications 2010. PMID: 20398633


  50. Goldman S, Lovett DH, Shalev E. Mechanisms of matrix metalloproteinase-2 (mmp-2) transcriptional repression by progesterone in jar choriocarcinoma cells. Volume 7. Reproductive biology and endocrinology : RB&E 2009. PMID: 19426551


  51. Mahimkar R, Nguyen A, Mann M, Yeh CC, Zhu BQ, Karliner JS, Lovett DH. Cardiac transgenic matrix metalloproteinase-2 expression induces myxomatous valve degeneration: a potential model of mitral valve prolapse disease. Volume 18 of Issue 5. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2008. PMID: 18835790


  52. Wetmore JB, Lovett DH, Hung AM, Cook-Wiens G, Mahnken JD, Sen S, Johansen KL. Associations of interleukin-6, C-reactive protein and serum amyloid A with mortality in haemodialysis patients. Volume 13 of Issue 7. Nephrology (Carlton, Vic.) 2008. PMID: 18826487


  53. Dang AB, Tay BK, Kim HT, Nauth A, Alfonso-Jaume MA, Lovett DH. Inhibition of MMP2/MMP9 after spinal cord trauma reduces apoptosis. Volume 33 of Issue 17. Spine 2008. PMID: 18670324


  54. McCloskey DT, Turcato S, Wang GY, Turnbull L, Zhu BQ, Bambino T, Nguyen AP, Lovett DH, Nissenson RA, Karliner JS, Baker AJ. Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy. Volume 294 of Issue 1. American journal of physiology. Heart and circulatory physiology 2007. PMID: 17965283


  55. Zhou HZ, Ma X, Gray MO, Zhu BQ, Nguyen AP, Baker AJ, Simonis U, Cecchini G, Lovett DH, Karliner JS. Transgenic MMP-2 expression induces latent cardiac mitochondrial dysfunction. Volume 358 of Issue 1. Biochemical and biophysical research communications 2007. PMID: 17475219


  56. Jansen PL, Rosch R, Jansen M, Binnebösel M, Junge K, Alfonso-Jaume A, Klinge U, Lovett DH, Mertens PR. Regulation of MMP-2 gene transcription in dermal wounds. Volume 127 of Issue 7. The Journal of investigative dermatology 2007. PMID: 17344928


  57. Jansen PL, Kever M, Rosch R, Krott E, Jansen M, Alfonso-Jaume A, Dooley S, Klinge U, Lovett DH, Mertens PR. Polymeric meshes induce zonal regulation of matrix metalloproteinase-2 gene expression by macrophages and fibroblasts. Volume 21 of Issue 4. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007. PMID: 17215487


  58. P. Lynen-Jansen, U. Klinge, D. H. Lovett, P. R. Mertens. Biomaterials: Disturbing Factors in Cell Cross-Talk and Gene Regulation. Recurrent Hernia 2007. PMID:


  59. Bergman MR, Teerlink JR, Mahimkar R, Li L, Zhu BQ, Nguyen A, Dahi S, Karliner JS, Lovett DH. Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction. Volume 292 of Issue 4. American journal of physiology. Heart and circulatory physiology 2006. PMID: 17158653


  60. Cheng S, Pollock AS, Mahimkar R, Olson JL, Lovett DH. Matrix metalloproteinase 2 and basement membrane integrity: a unifying mechanism for progressive renal injury. Volume 20 of Issue 11. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006. PMID: 16891619


  61. Wetmore JB, Johansen KL, Sen S, Hung AM, Lovett DH. An angiotensin converting enzyme haplotype predicts survival in patients with end stage renal disease. Volume 120 of Issue 2. Human genetics 2006. PMID: 16791616


  62. Mukherjee R, Mingoia JT, Bruce JA, Austin JS, Stroud RE, Escobar GP, McClister DM, Allen CM, Alfonso-Jaume MA, Fini ME, Lovett DH, Spinale FG. Selective spatiotemporal induction of matrix metalloproteinase-2 and matrix metalloproteinase-9 transcription after myocardial infarction. Volume 291 of Issue 5. American journal of physiology. Heart and circulatory physiology 2006. PMID: 16766634


  63. Alfonso-Jaume MA, Bergman MR, Mahimkar R, Cheng S, Jin ZQ, Karliner JS, Lovett DH. Cardiac ischemia-reperfusion injury induces matrix metalloproteinase-2 expression through the AP-1 components FosB and JunB. Volume 291 of Issue 4. American journal of physiology. Heart and circulatory physiology 2006. PMID: 16699069


  64. J.G. Lee, D.H. Lovett, S. Dahi. Intronic regulation mediates ischemia-induced MMP-2 transcription. Journal of Surgical Research 2006. PMID:


  65. P. Lynen Jansen, M. Hungol, E. Krott, M. Jansen, D. Lovett, U. Klinge, P. R. Mertens. Response element 1 reguliert die Expression der MMP-2 in der Wundheilung Ergebnisse aus dem transgenen Mausmodell. Chirurgisches Forum 2006 2006. PMID:


  66. Lee JG, Dahi S, Mahimkar R, Tulloch NL, Alfonso-Jaume MA, Lovett DH, Sarkar R. Intronic regulation of matrix metalloproteinase-2 revealed by in vivo transcriptional analysis in ischemia. Volume 102 of Issue 45. Proceedings of the National Academy of Sciences of the United States of America 2005. PMID: 16258061


  67. Wang GY, Bergman MR, Nguyen AP, Turcato S, Swigart PM, Rodrigo MC, Simpson PC, Karliner JS, Lovett DH, Baker AJ. Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility. Volume 69 of Issue 3. Cardiovascular research 2005. PMID: 16183043


  68. Dahi S, Lee JG, Lovett DH, Sarkar R. Differential transcriptional activation of matrix metalloproteinase-2 and membrane type-1 matrix metalloproteinase by experimental deep venous thrombosis and thrombin. Volume 42 of Issue 3. Journal of vascular surgery 2005. PMID: 16171603


  69. Wetmore JB, Hung AM, Lovett DH, Sen S, Quershy O, Johansen KL. Interleukin-1 gene cluster polymorphisms predict risk of ESRD. Volume 68 of Issue 1. Kidney international 2005. PMID: 15954918


  70. Parsa A, Lovett DH, Peden EA, Zhu L, Seldin MF, Criswell LA. Renin-angiotensin system gene polymorphisms predict the progression to renal insufficiency among Asians with lupus nephritis. Volume 6 of Issue 3. Genes and immunity 2005. PMID: 15789057


  71. Mahimkar RM, Visaya O, Pollock AS, Lovett DH. The disintegrin domain of ADAM9: a ligand for multiple beta1 renal integrins. Volume 385 of Issue Pt 2. The Biochemical journal 2005. PMID: 15361064


  72. Petra Lynen Jansen, M. Jansen, M. Hungol, E. Krott, D. Lovett, P. R. Mertens, U. Klinge. Alloplastische Netzmaterialien induzieren die MMP-2 Promotoraktivität — Ergebnisse aus dem transgenen Mausmodell. Chirurgisches Forum 2005 2005. PMID:


  73. En-Nia A, Yilmaz E, Klinge U, Lovett DH, Stefanidis I, Mertens PR. Transcription factor YB-1 mediates DNA polymerase alpha gene expression. Volume 280 of Issue 9. The Journal of biological chemistry 2004. PMID: 15615704


  74. Rajabrata Sarkar, Jackie Lee, Rajeev Mahimkar, David Lovett. P53, YB-1 and the AP-1 family of transcription factors mediate MMP-2 transcription induced by skeletal muscle ischemia. Journal of the American College of Surgeons 2004. PMID:


  75. Alfonso-Jaume MA, Mahimkar R, Lovett DH. Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells. Volume 380 of Issue Pt 3. The Biochemical journal 2004. PMID: 14979875


  76. Cheng S, Lovett DH. Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation. Volume 162 of Issue 6. The American journal of pathology 2003. PMID: 12759250


  77. Harendza S, Lovett DH, Panzer U, Lukacs Z, Kuhnl P, Stahl RA. Linked common polymorphisms in the gelatinase a promoter are associated with diminished transcriptional response to estrogen and genetic fitness. Volume 278 of Issue 23. The Journal of biological chemistry 2003. PMID: 12657623


  78. Bergman MR, Cheng S, Honbo N, Piacentini L, Karliner JS, Lovett DH. A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers. Volume 369 of Issue Pt 3. The Biochemical journal 2003. PMID: 12371906


  79. Pollock AS, Turck J, Lovett DH. The prodomain of interleukin 1alpha interacts with elements of the RNA processing apparatus and induces apoptosis in malignant cells. Volume 17 of Issue 2. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003. PMID: 12554699


  80. Cheng S, Alfonso-Jaume MA, Mertens PR, Lovett DH. Tumour metastasis suppressor, nm23-beta, inhibits gelatinase A transcription by interference with transactivator Y-box protein-1 (YB-1). Volume 366 of Issue Pt 3. The Biochemical journal 2002. PMID: 12010125


  81. Reisdorff J, En-Nia A, Stefanidis I, Floege J, Lovett DH, Mertens PR. Transcription factor Ets-1 regulates gelatinase a gene expression in mesangial cells. Volume 13 of Issue 6. Journal of the American Society of Nephrology : JASN 2002. PMID: 12039986


  82. Mertens PR, Steinmann K, Alfonso-Jaume MA, En-Nia A, Sun Y, Lovett DH. Combinatorial interactions of p53, activating protein-2, and YB-1 with a single enhancer element regulate gelatinase A expression in neoplastic cells. Volume 277 of Issue 28. The Journal of biological chemistry 2002. PMID: 11973333


  83. Ikeda K, Wang LH, Torres R, Zhao H, Olaso E, Eng FJ, Labrador P, Klein R, Lovett D, Yancopoulos GD, Friedman SL, Lin HC. Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen. Volume 277 of Issue 21. The Journal of biological chemistry 2002. PMID: 11884411


  84. Olaso E, Labrador JP, Wang L, Ikeda K, Eng FJ, Klein R, Lovett DH, Lin HC, Friedman SL. Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2. Volume 277 of Issue 5. The Journal of biological chemistry 2001. PMID: 11723120


  85. Harendza S, Lovett DH, Stahl RA. The hematopoietic transcription factor PU.1 represses gelatinase A transcription in glomerular mesangial cells. Volume 275 of Issue 26. The Journal of biological chemistry 2000. PMID: 10867017


  86. Mahimkar RM, Baricos WH, Visaya O, Pollock AS, Lovett DH. Identification, cellular distribution and potential function of the metalloprotease-disintegrin MDC9 in the kidney. Volume 11 of Issue 4. Journal of the American Society of Nephrology : JASN 2000. PMID: 10752518


  87. Mertens PR, Alfonso-Jaume MA, Steinmann K, Lovett DH. YB-1 regulation of the human and rat gelatinase A genes via similar enhancer elements. Volume 10 of Issue 12. Journal of the American Society of Nephrology : JASN 1999. PMID: 10589685


  88. Mertens PR, Alfonso-Jaume MA, Steinmann K, Lovett DH. A synergistic interaction of transcription factors AP2 and YB-1 regulates gelatinase A enhancer-dependent transcription. Volume 273 of Issue 49. The Journal of biological chemistry 1998. PMID: 9830047


  89. Tanney DC, Feng L, Pollock AS, Lovett DH. Regulated expression of matrix metalloproteinases and TIMP in nephrogenesis. Volume 213 of Issue 1. Developmental dynamics : an official publication of the American Association of Anatomists 1998. PMID: 9733107


  90. Mertens PR, Harendza S, Pollock AS, Lovett DH. Glomerular mesangial cell-specific transactivation of matrix metalloproteinase 2 transcription is mediated by YB-1. Volume 272 of Issue 36. The Journal of biological chemistry 1997. PMID: 9278454


  91. Turck J, Pollock AS, Lovett DH. Gelatinase A is a glomerular mesangial cell growth and differentiation factor. Volume 51 of Issue 5. Kidney international 1997. PMID: 9150450


  92. Stevenson FT, Turck J, Locksley RM, Lovett DH. The N-terminal propiece of interleukin 1 alpha is a transforming nuclear oncoprotein. Volume 94 of Issue 2. Proceedings of the National Academy of Sciences of the United States of America 1997. PMID: 9012814


  93. McMillan JI, Weeks R, West JW, Bursten S, Rice GC, Lovett DH. Pharmacological inhibition of gelatinase B induction and tumor cell invasion. Volume 67 of Issue 4. International journal of cancer 1996. PMID: 8759612


  94. Turck J, Pollock AS, Lee LK, Marti HP, Lovett DH. Matrix metalloproteinase 2 (gelatinase A) regulates glomerular mesangial cell proliferation and differentiation. Volume 271 of Issue 25. The Journal of biological chemistry 1996. PMID: 8663054


  95. McMillan JI, Riordan JW, Couser WG, Pollock AS, Lovett DH. Characterization of a glomerular epithelial cell metalloproteinase as matrix metalloproteinase-9 with enhanced expression in a model of membranous nephropathy. Volume 97 of Issue 4. The Journal of clinical investigation 1996. PMID: 8613533


  96. Harendza S, Pollock AS, Mertens PR, Lovett DH. Tissue-specific enhancer-promoter interactions regulate high level constitutive expression of matrix metalloproteinase 2 by glomerular mesangial cells. Volume 270 of Issue 32. The Journal of biological chemistry 1995. PMID: 7642529


  97. Lee LK, Meyer TW, Pollock AS, Lovett DH. Endothelial cell injury initiates glomerular sclerosis in the rat remnant kidney. Volume 96 of Issue 2. The Journal of clinical investigation 1995. PMID: 7635988


  98. Lovett DH. Immunologic glomerular disease--new prospects for specific therapy. Volume 160 of Issue 5. The Western journal of medicine 1994. PMID: 8048244


  99. Johnson RJ, Lovett D, Lehrer RI, Couser WG, Klebanoff SJ. Role of oxidants and proteases in glomerular injury. Volume 45 of Issue 2. Kidney international 1994. PMID: 8164419


  100. Gaire M, Magbanua Z, McDonnell S, McNeil L, Lovett DH, Matrisian LM. Structure and expression of the human gene for the matrix metalloproteinase matrilysin. Volume 269 of Issue 3. The Journal of biological chemistry 1994. PMID: 8294454


  101. Marti HP, Lee L, Kashgarian M, Lovett DH. Transforming growth factor-beta 1 stimulates glomerular mesangial cell synthesis of the 72-kd type IV collagenase. Volume 144 of Issue 1. The American journal of pathology 1994. PMID: 8291614


  102. Johnson RJ, Lovett D. In vivo gene transfer, Koch's postulates, and renal disease. Volume 92 of Issue 6. The Journal of clinical investigation 1993. PMID: 8254014


  103. Lee LK, Pollock AS, Lovett DH. Asymmetric origins of the mature glomerular basement membrane. Volume 157 of Issue 1. Journal of cellular physiology 1993. PMID: 8408235


  104. Stevenson FT, Bursten SL, Fanton C, Locksley RM, Lovett DH. The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece. Volume 90 of Issue 15. Proceedings of the National Academy of Sciences of the United States of America 1993. PMID: 8346241


  105. Marti HP, McNeil L, Davies M, Martin J, Lovett DH. Homology cloning of rat 72 kDa type IV collagenase: cytokine and second-messenger inducibility in glomerular mesangial cells. Volume 291 ( Pt 2). The Biochemical journal 1993. PMID: 7916617


  106. Marti HP, Lovett DH. [Current aspects in the pathogenesis and therapy of glomerulonephritis: significance of glomerular metalloproteinases]. Volume 122 of Issue 45. Schweizerische medizinische Wochenschrift 1992. PMID: 1439688


  107. Stevenson FT, Bursten SL, Locksley RM, Lovett DH. Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues. Volume 176 of Issue 4. The Journal of experimental medicine 1992. PMID: 1402651


  108. Stevenson FT, Torrano F, Locksley RM, Lovett DH. Interleukin 1: the patterns of translation and intracellular distribution support alternative secretory mechanisms. Volume 152 of Issue 2. Journal of cellular physiology 1992. PMID: 1639857


  109. Marti HP, McNeil L, Thomas G, Davies M, Lovett DH. Molecular characterization of a low-molecular-mass matrix metalloproteinase secreted by glomerular mesangial cells as PUMP-1. Volume 285 ( Pt 3). The Biochemical journal 1992. PMID: 1497627


  110. Lovett DH, Johnson RJ, Marti HP, Martin J, Davies M, Couser WG. Structural characterization of the mesangial cell type IV collagenase and enhanced expression in a model of immune complex-mediated glomerulonephritis. Volume 141 of Issue 1. The American journal of pathology 1992. PMID: 1321565


  111. Pollock AS, Lovett DH. Expression of phosphoenolpyruvate carboxykinase (PEPCK) chimeras in renal epithelial cells. Retention of appropriate physiological responsiveness using enhancerless retroviral vectors. Volume 284 ( Pt 3). The Biochemical journal 1992. PMID: 1377912


  112. Johnson R, Yamabe H, Chen YP, Campbell C, Gordon K, Baker P, Lovett D, Couser WG. Glomerular epithelial cells secrete a glomerular basement membrane-degrading metalloproteinase. Volume 2 of Issue 9. Journal of the American Society of Nephrology : JASN 1992. PMID: 1627762


  113. Davies M, Martin J, Thomas GJ, Lovett DH. Proteinases and glomerular matrix turnover. Volume 41 of Issue 3. Kidney international 1992. PMID: 1573845


  114. Bursten SL, Harris WE, Resch K, Lovett DH. Lipid A activation of glomerular mesangial cells: mimicry of the bioactive lipid, phosphatidic acid. Volume 262 of Issue 2 Pt 1. The American journal of physiology 1992. PMID: 1539625


  115. Bursten SL, Harris WE, Bomsztyk K, Lovett D. Interleukin-1 rapidly stimulates lysophosphatidate acyltransferase and phosphatidate phosphohydrolase activities in human mesangial cells. Volume 266 of Issue 31. The Journal of biological chemistry 1991. PMID: 1657935


  116. Bursten SL, Stevenson F, Torrano F, Lovett DH. Mesangial cell activation by bacterial endotoxin. Induction of rapid cytoskeletal reorganization and gene expression. Volume 139 of Issue 2. The American journal of pathology 1991. PMID: 1867323


  117. Davies M, Coles GA, Thomas GJ, Martin J, Lovett DH. Proteinases and the glomerulus: their role in glomerular diseases. Volume 68 of Issue 22. Klinische Wochenschrift 1990. PMID: 2280577


  118. Bommer J, Weinreich T, Lovett DH, Bouillon R, Ritz E, Gemsa D. Particles from dialysis tubing stimulate interleukin-1 secretion by macrophages. Volume 5 of Issue 3. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1990. PMID: 2113649


  119. Martin J, Davies M, Thomas G, Lovett DH. Human mesangial cells secrete a GBM-degrading neutral proteinase and a specific inhibitor. Volume 36 of Issue 5. Kidney international 1989. PMID: 2559235


  120. Martin M, Lovett DH, Szamel M, Resch K. Characterization of the interleukin-1-induced tyrosine phosphorylation of a 41-kDa plasma membrane protein of the human tumor cell line K 562. Volume 180 of Issue 2. European journal of biochemistry 1989. PMID: 2784384


  121. Lovett DH, Bursten SL, Gemsa D, Bessler W, Resch K, Ryan JL. Activation of glomerular mesangial cells by gram-negative bacterial cell wall components. Volume 133 of Issue 3. The American journal of pathology 1988. PMID: 3059803


  122. Person JM, Lovett DH, Raugi GJ. Modulation of mesangial cell migration by extracellular matrix components. Inhibition by heparinlike glycosaminoglycans. Volume 133 of Issue 3. The American journal of pathology 1988. PMID: 3202119


  123. Bursten SL, Locksley RM, Ryan JL, Lovett DH. Acylation of monocyte and glomerular mesangial cell proteins. Myristyl acylation of the interleukin 1 precursors. Volume 82 of Issue 5. The Journal of clinical investigation 1988. PMID: 3263392


  124. Abrass CK, Raugi GJ, Gabourel LS, Lovett DH. Insulin and insulin-like growth factor I binding to cultured rat glomerular mesangial cells. Volume 123 of Issue 5. Endocrinology 1988. PMID: 3049050


  125. Lovett DH, Larsen A. Cell cycle-dependent interleukin 1 gene expression by cultured glomerular mesangial cells. Volume 82 of Issue 1. The Journal of clinical investigation 1988. PMID: 3260603


  126. Lovett DH, Martin M, Bursten S, Szamel M, Gemsa D, Resch K. Interleukin 1 and the glomerular mesangium. III. IL-1-dependent stimulation of mesangial cell protein kinase activity. Volume 34 of Issue 1. Kidney international 1988. PMID: 3262785


  127. Davies M, Thomas GJ, Martin J, Lovett DH. The purification and characterization of a glomerular-basement-membrane-degrading neutral proteinase from rat mesangial cells. Volume 251 of Issue 2. The Biochemical journal 1988. PMID: 2840892


  128. Lovett DH, Resch K, Gemsa D. Interleukin I and the glomerular mesangium. II. Monokine stimulation of mesangial cell prostanoid secretion. Volume 129 of Issue 3. The American journal of pathology 1987. PMID: 3322024


  129. Raugi GJ, Lovett DH. Thrombospondin secretion by cultured human glomerular mesangial cells. Volume 129 of Issue 2. The American journal of pathology 1987. PMID: 3314532


  130. Lovett DH, Haensch GM, Goppelt M, Resch K, Gemsa D. Activation of glomerular mesangial cells by the terminal membrane attack complex of complement. Volume 138 of Issue 8. Journal of immunology (Baltimore, Md. : 1950) 1987. PMID: 3494069


  131. Sterzel RB, Lovett DH, Foellmer HG, Perfetto M, Biemesderfer D, Kashgarian M. Mesangial cell hillocks. Nodular foci of exaggerated growth of cells and matrix in prolonged culture. Volume 125 of Issue 1. The American journal of pathology 1986. PMID: 3535527


  132. Resch K, Martin M, Lovett DH, Kyas U, Gemsa D. The receptor for interleukin 1 in plasma membranes of the human leukemia cell K 562: biological and biochemical characterization. Volume 172 of Issue 3-5. Immunobiology 1986. PMID: 2948903


  133. Lovett DH, Sterzel RB. Cell culture approaches to the analysis of glomerular inflammation. Volume 30 of Issue 2. Kidney international 1986. PMID: 3531678


  134. Martin J, Lovett DH, Gemsa D, Sterzel RB, Davies M. Enhancement of glomerular mesangial cell neutral proteinase secretion by macrophages: role of interleukin 1. Volume 137 of Issue 2. Journal of immunology (Baltimore, Md. : 1950) 1986. PMID: 3013993


  135. Lovett DH, Szamel M, Ryan JL, Sterzel RB, Gemsa D, Resch K. Interleukin 1 and the glomerular mesangium. I. Purification and characterization of a mesangial cell-derived autogrowth factor. Volume 136 of Issue 10. Journal of immunology (Baltimore, Md. : 1950) 1986. PMID: 3486219


  136. Martin M, Lovett D, Resch K. Interleukin 1 induces specific phosphorylation of a 41 kDa plasma membrane protein from the human tumor cell line K 562. Immunobiology 1986. PMID: 3486814


  137. Lovett D, Kozan B, Hadam M, Resch K, Gemsa D. Macrophage cytotoxicity: interleukin 1 as a mediator of tumor cytostasis. Volume 136 of Issue 1. Journal of immunology (Baltimore, Md. : 1950) 1986. PMID: 2999248


  138. Resch K, Martin M, Lovett DH, Gemsa D. Measurement of interleukin-1 by growth inhibition of the human tumor cell K562; receptor studies. Volume 5 Suppl 1. Lymphokine research 1986. PMID: 2946904


  139. D. GEMSA, M. NAIN, G.M. HÄNSCH, D. LOVETT, P.H. KRAMMER, K. RESCH. Release of Prostaglandins and Modulation of Leukocyte Functions. Advances in Immunopharmacology 1986. PMID:


  140. Lovett DH, Sterzel RB, Ryan JL, Atkins E. Production of an endogenous pyrogen by glomerular mesangial cells. Volume 134 of Issue 2. Journal of immunology (Baltimore, Md. : 1950) 1985. PMID: 3871212


  141. Stoeck M, Wildhagen K, Szamel M, Lovett D, Resch K. Studies on the mechanism whereby cyclosporin A inhibits T-lymphocyte activation. Volume 169 of Issue 1. Immunobiology 1985. PMID: 2580777


  142. Lovett DH, Ryan JL, Sterzel RB. Stimulation of rat mesangial cell proliferation by macrophage interleukin 1. Volume 131 of Issue 6. Journal of immunology (Baltimore, Md. : 1950) 1983. PMID: 6605992


  143. Lovett DH, Ryan JL, Sterzel RB. A thymocyte-activating factor derived from glomerular mesangial cells. Volume 130 of Issue 4. Journal of immunology (Baltimore, Md. : 1950) 1983. PMID: 6601138


  144. Lovett DH, Sterzel RB, Kashgarian M, Ryan JL. Neutral proteinase activity produced in vitro by cells of the glomerular mesangium. Volume 23 of Issue 2. Kidney international 1983. PMID: 6405073


  145. Sterzel RB, Lovett DH, Stein HD, Kashgarian M. The mesangium and glomerulonephritis. Volume 60 of Issue 18. Klinische Wochenschrift 1982. PMID: 7144055


  146. Lovett DH, Ryan JL, Kashgarian M, Sterzel RB. Lysosomal enzymes in glomerular cells of the rat. Volume 107 of Issue 2. The American journal of pathology 1982. PMID: 6282126


  147. Mazur EM, Lovett DH, Enriquez RE, Breg WR, Papac RJ. Angioimmunoblastic lymphadenopathy evolution to a Burkitt-like lymphoma. Volume 67 of Issue 2. The American journal of medicine 1979. PMID: 313708