Hong-Erh Liang, PhD, MS, BS

Professor

Allergic immunologic diseases.

Publications

  1. Nguyen TTT, Lu W, Zhu WS, Ansel KM, Liang HE, Weiss A. Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells. Proceedings of the National Academy of Sciences of the United States of America 2023. PMID: 37307442


  2. Ricardo-Gonzalez RR, Kotas ME, O'Leary CE, Singh K, Damsky W, Liao C, Arouge E, Tenvooren I, Marquez DM, Schroeder AW, Cohen JN, Fassett MS, Lee J, Daniel SG, Bittinger K, Díaz RE, Fraser JS, Ali N, Ansel KM, Spitzer MH, Liang HE, Locksley RM. Innate type 2 immunity controls hair follicle commensalism by Demodex mites. Immunity 2022. PMID: 36044899


  3. Roberto R Ricardo-Gonzalez, Maya E Kotas, Claire O’Leary, Iliana Tenvooren, Diana Marquez, Katelyn Singh, William Damsky, Chang Liao, Andrew Schroeder, Jarish Cohen, Marlys S Fassett, Jinwoo Lee, Scott G Daniel, Kyle Bittinger, Roberto Efrain Diaz, James Fraser, Karl Mark Ansel, Matthew Spitzer, Hong-Erh Liang, Richard M Locksley. Innate type 2 immunity controls hair follicle commensalism by Demodex mites. The Journal of Immunology 2022. PMID:


  4. O'Leary CE, Sbierski-Kind J, Kotas ME, Wagner JC, Liang HE, Schroeder AW, de Tenorio JC, von Moltke J, Ricardo-Gonzalez RR, Eckalbar WL, Molofsky AB, Schneider C, Locksley RM. Bile acid-sensitive tuft cells regulate biliary neutrophil influx. 2022. PMID: 35245089


  5. Cautivo KM, Matatia PR, Lizama CO, Mroz NM, Dahlgren MW, Yu X, Sbierski-Kind J, Taruselli MT, Brooks JF, Wade-Vallance A, Caryotakis SE, Chang AA, Liang HE, Zikherman J, Locksley RM, Molofsky AB. Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation. 2022. PMID: 35139352


  6. Chuntova P, Hou Y, Naka R, Yamamichi A, Chen T, Goretsky Y, Hatae R, Nejo T, Kohanbash G, Mende AL, Montoya M, Downey KM, Diebold D, Skinner J, Liang HE, Schwer B, Okada H. Novel EGFRvIII-CAR transgenic mice for rigorous preclinical studies in syngeneic mice. 2021. PMID: 34347086


  7. Castellanos CA, Ren X, Gonzalez SL, Li HK, Schroeder AW, Liang HE, Laidlaw BJ, Hu D, Mak ACY, Eng C, Rodríguez-Santana JR, LeNoir M, Yan Q, Celedón JC, Burchard EG, Zamvil SS, Ishido S, Locksley RM, Cyster JG, Huang X, Shin JS. Lymph node-resident dendritic cells drive TH2 cell development involving MARCH1. 2021. PMID: 34652961


  8. Kotas ME, Mroz NM, Koga S, Liang HE, Schroeder AW, Ricardo-Gonzalez RR, Schneider C, Locksley RM. CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone. Mucosal immunology 2021. PMID: 34290377


  9. Carlos A Castellanos, Xin Ren, Hong-Erh Liang, Brian J Laidlaw, Andrea Barczak, Joshua Rudolph, Walter L Eckalbar, Xiaozhu Huang, Jason G Cyster, Richard M Locksley, David J Erle, Satoshi Ishido, Jeoung-Sook Shin. Development of allergic airway immunity depends on MARCH1-mediated ubiquitination of MHCII and CD86 in dendritic cells. The Journal of Immunology 2020. PMID:


  10. Ricardo-Gonzalez RR, Schneider C, Liao C, Lee J, Liang HE, Locksley RM. Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity. The Journal of experimental medicine 2020. PMID: 32031571


  11. Schneider C, Lee J, Koga S, Ricardo-Gonzalez RR, Nussbaum JC, Smith LK, Villeda SA, Liang HE, Locksley RM. Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming. Immunity 2019. PMID: 31128962


  12. Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM. Tissue signals imprint ILC2 identity with anticipatory function. Nature immunology 2018. PMID: 30201992


  13. Schneider C, O'Leary CE, von Moltke J, Liang HE, Ang QY, Turnbaugh PJ, Radhakrishnan S, Pellizzon M, Ma A, Locksley RM. A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling. Volume 174 of Issue 2. Cell 2018. PMID: 29887373


  14. . 1021 Origin of type 2 innate lymphoid cells in the skin. 2018. PMID:


  15. Savage AK, Liang HE, Locksley RM. The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine. Volume 199 of Issue 5. Journal of immunology (Baltimore, Md. : 1950) 2017. PMID: 28747343


  16. Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley RM. Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease. Volume 169 of Issue 3. Cell 2017. PMID: 28431248


  17. Hsu LY, Cheng DA, Chen Y, Liang HE, Weiss A. Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness. The Journal of experimental medicine 2017. PMID: 28159798


  18. Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM. A tissue checkpoint regulates type 2 immunity. Volume 17 of Issue 12. Nature immunology 2016. PMID: 27749840


  19. von Moltke J, Ji M, Liang HE, Locksley RM. Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Volume 529 of Issue 7585. Nature 2015. PMID: 26675736


  20. Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley RM. Interleukin-33 and Interferon-? Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Volume 43 of Issue 1. Immunity 2015. PMID: 26092469


  21. . IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. 2015. PMID:


  22. Cheng LE, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley RM. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. Volume 212 of Issue 4. The Journal of experimental medicine 2015. PMID: 25779634


  23. Reinhardt RL, Liang HE, Bao K, Price AE, Mohrs M, Kelly BL, Locksley RM. A novel model for IFN-?-mediated autoinflammatory syndromes. Volume 194 of Issue 5. Journal of immunology (Baltimore, Md. : 1950) 2015. PMID: 25637019


  24. Bando JK, Liang HE, Locksley RM. Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine. Volume 16 of Issue 2. Nature immunology 2014. PMID: 25501629


  25. Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM. Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and ?d T cells. Volume 40 of Issue 3. Immunity 2014. PMID: 24631157


  26. Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM. Type 2 innate lymphoid cells control eosinophil homeostasis. Volume 502 of Issue 7470. Nature 2013. PMID: 24037376


  27. . 265 Cooperative activation of innate lymphoid type 2 cells (ILC2) by epithelial cytokines in response to chitin. 2013. PMID:


  28. Bando JK, Nussbaum JC, Liang HE, Locksley RM. Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung. Volume 94 of Issue 5. Journal of leukocyte biology 2013. PMID: 23924659


  29. Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. Volume 210 of Issue 3. The Journal of experimental medicine 2013. PMID: 23420878


  30. Price AE, Reinhardt RL, Liang HE, Locksley RM. Marking and quantifying IL-17A-producing cells in vivo. Volume 7 of Issue 6. PloS one 2012. PMID: 22768117


  31. Liang HE, Reinhardt RL, Bando JK, Sullivan BM, Ho IC, Locksley RM. Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. Volume 13 of Issue 1. Nature immunology 2011. PMID: 22138715


  32. Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley RM. Genetic analysis of basophil function in vivo. Volume 12 of Issue 6. Nature immunology 2011. PMID: 21552267


  33. Ari Molofsky, Davina Wu, Hong-Erh Liang, Jennifer Bando, Hani Jouihan, Robert Ricardo-Gonzalez, Ajay Chawla, Richard Locksley. Adipose eosinophils promote alternatively activated macrophages that maintain metabolic homeostasis (151.21). The Journal of Immunology 2011. PMID:


  34. Jennifer Bando, Hong-Erh Liang, Richard Locksley. Arginase-I is expressed by ckit+IL-7Ra+ populations in cryptopatches (166.11). The Journal of Immunology 2011. PMID:


  35. Richard Reinhardt, Hong-Erh Liang, Brandon Sullivan, Richard Locksley. Divergent expression patterns of IL-4 and IL-13 define unique functions in type 2 immunity (56.22). The Journal of Immunology 2011. PMID:


  36. Brandon Sullivan, Hong-Erh Liang, Jennifer Bando, Davina Wu, Laurence Cheng, James McKerrow, Chris Allen, Richard Locksley. Genetic analysis of basophil function in vivo (151.22). The Journal of Immunology 2011. PMID:


  37. Jesse Nussbaum, Hong-Erh Liang, Brandon Sullivan, April Price, Richard Locksley. Innate and adaptive Type 2 cytokines drive mucosal eosinophilia (58.2). The Journal of Immunology 2011. PMID:


  38. April Price, Hong-Erh Liang, R. Lee Reinhardt, Richard Locksley. Tracking in vivo IL-17A production during infection and autoimmunity (114.11). The Journal of Immunology 2011. PMID:


  39. Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Volume 332 of Issue 6026. Science (New York, N.Y.) 2011. PMID: 21436399


  40. Price AE, Liang HE, Sullivan BM, Reinhardt RL, Eisley CJ, Erle DJ, Locksley RM. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Volume 107 of Issue 25. Proceedings of the National Academy of Sciences of the United States of America 2010. PMID: 20534524


  41. . Tracking cytokine expression in vivo. 2009. PMID:


  42. Voehringer D, Wu D, Liang HE, Locksley RM. Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates. Volume 9. BMC biotechnology 2009. PMID: 19638212


  43. Richard Lee Reinhardt, Hong-Erh Liang, Richard M. Locksley. Cytokine-secreting follicular T cells shape the antibody repertoire (34.19). The Journal of Immunology 2009. PMID:


  44. April E Price, Hong-Erh Liang, Richard M Locksley. Generation of IL-17A reporter mice to track IL-17A expression in vivo (38.19). The Journal of Immunology 2009. PMID:


  45. Brandon M Sullivan, Davina Wu, Hong-Erh Liang, P'ng Loke, James H McKerrow, David Voehringer, Richard M Locksley. Tissue restricted activation of basophils mediates primary immunity against helminthes (79.22). The Journal of Immunology 2009. PMID:


  46. Reinhardt RL, Liang HE, Locksley RM. Cytokine-secreting follicular T cells shape the antibody repertoire. Volume 10 of Issue 4. Nature immunology 2009. PMID: 19252490


  47. Kang SJ, Liang HE, Reizis B, Locksley RM. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Volume 29 of Issue 5. Immunity 2008. PMID: 19006696


  48. Voehringer D, Liang HE, Locksley RM. Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice. Volume 180 of Issue 7. Journal of immunology (Baltimore, Md. : 1950) 2008. PMID: 18354198


  49. Reese TA, Liang HE, Tager AM, Luster AD, Van Rooijen N, Voehringer D, Locksley RM. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Volume 447 of Issue 7140. Nature 2007. PMID: 17450126


  50. Reinhardt RL, Kang SJ, Liang HE, Locksley RM. T helper cell effector fates--who, how and where? Volume 18 of Issue 3. Current opinion in immunology 2006. PMID: 16617008


  51. Xia M, Imredy JP, Santarelli VP, Liang HA, Condra CL, Bennett P, Koblan KS, Connolly TM. Generation and characterization of a cell line with inducible expression of Ca(v)3.2 (T-type) channels. Assay and drug development technologies 2003. PMID: 15090236