Jan Christoph, PhD, MSc

Asst Professor In Residence

Jan Christoph studies the heart from a complex and dynamical systems perspective. He is interested in arrhythmia mechanisms and the coupling between electrophysiology and tissue mechanics, as well as electromechanical feedback. He uses computational methods, artificial intelligence and high-resolution imaging to study the heart.

Publications

  1. Baranwal T, Lebert J, Christoph J. Dreaming of Electrical Waves: Generative Modeling of Cardiac Excitation Waves using Diffusion Models. ArXiv 2024. PMID: 38883235


  2. Christoph J, Ripplinger CM. Paralysis by analysis: Overcoming cardiac contraction with computer vision. Proceedings of the National Academy of Sciences of the United States of America 2023. PMID: 37792520


  3. Kappadan V, Sohi A, Parlitz U, Luther S, Uzelac I, Fenton F, Peters NS, Christoph J, Ng FS. Optical mapping of contracting hearts. The Journal of physiology 2023. PMID: 36866700


  4. M?nkler P, Klatt N, Scherschel K, Kuklik P, Jungen C, Cavus E, Eickholt C, Christoph J, Lemoine MD, Christ T, Willems S, Riedel R, Kirchhof P, Meyer C. Repolarization indicates electrical instability in ventricular arrhythmia originating from papillary muscle. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2023. PMID: 35989424


  5. Lebert J, Mittal M, Christoph J. Reconstruction of three-dimensional scroll waves in excitable media from two-dimensional observations using deep neural networks. Physical review. E 2023. PMID: 36797900


  6. Lebert J, Ravi N, Kensah G, Christoph J. Real-Time Optical Mapping of Contracting Cardiac Tissues With GPU-Accelerated Numerical Motion Tracking. Volume 9. Frontiers in cardiovascular medicine 2022. PMID: 35686036


  7. Lebert J, Ravi N, Fenton FH, Christoph J. Rotor Localization and Phase Mapping of Cardiac Excitation Waves Using Deep Neural Networks. Volume 12. Frontiers in physiology 2021. PMID: 34975536


  8. Vogt M, Schulz B, Wagdi A, Lebert J, van Belle GJ, Christoph J, Bruegmann T, Patejdl R. Direct optogenetic stimulation of smooth muscle cells to control gastric contractility. Volume 11 of Issue 11. Theranostics 2021. PMID: 33859764


  9. Christoph J, Lebert J. Inverse mechano-electrical reconstruction of cardiac excitation wave patterns from mechanical deformation using deep learning. Volume 30 of Issue 12. Chaos (Woodbury, N.Y.) 2020. PMID: 33380038


  10. Kappadan V, Telele S, Uzelac I, Fenton F, Parlitz U, Luther S, Christoph J. High-Resolution Optical Measurement of Cardiac Restitution, Contraction, and Fibrillation Dynamics in Beating vs. Blebbistatin-Uncoupled Isolated Rabbit Hearts. Volume 11. Frontiers in physiology 2020. PMID: 32528304


  11. Lebert J, Christoph J. Synchronization-based reconstruction of electromechanical wave dynamics in elastic excitable media. Volume 29 of Issue 9. Chaos (Woodbury, N.Y.) 2019. PMID: 31575136


  12. Christoph J, Luther S. Marker-Free Tracking for Motion Artifact Compensation and Deformation Measurements in Optical Mapping Videos of Contracting Hearts. Volume 9. Frontiers in physiology 2018. PMID: 30450053


  13. Christoph J, Chebbok M, Richter C, Schröder-Schetelig J, Bittihn P, Stein S, Uzelac I, Fenton FH, Hasenfuß G, Gilmour RF, Luther S. Electromechanical vortex filaments during cardiac fibrillation. Volume 555 of Issue 7698. Nature 2018. PMID: 29466325


  14. Christoph J, Schröder-Schetelig J, Luther S. Electromechanical optical mapping. Volume 130 of Issue Pt B. Progress in biophysics and molecular biology 2017. PMID: 28947080


  15. Lilienkamp T, Christoph J, Parlitz U. Features of Chaotic Transients in Excitable Media Governed by Spiral and Scroll Waves. Volume 119 of Issue 5. Physical review letters 2017. PMID: 28949756


  16. Richter C, Christoph J, Lehnart SE, Luther S. Optogenetic Light Crafting Tools for the Control of Cardiac Arrhythmias. Volume 1408. Methods in molecular biology (Clifton, N.J.) 2016. PMID: 26965131