Jay Nadel, MD

PROF EMERITUS(WOS)

A. Background
• 1968 appointed the first Chief of the Division of Pulmonary Diseases in the Department of Medicine, UCSF
• Lobbied Congress to rename the National Heart Institute to the National Heart and Lung Institute
• Co-Editor of the Murray/Nadel Textbook of Respiratory Medicine

B. Early Areas of Studies
• Chronic airway diseases, including asthma, COPD, and CF
• Air pollutants (sulfur dioxide and ozone)
• Airway epithelium
• Viruses, bacteria, air pollutants, allergens, cigarette smoke
• Na+, Cl¯ exchange mechanism in the airway epithelium

C. Later Areas of Study
• Cell and molecular biology
• Antimuscarinic Therapy of Bronchospasm
• Signaling pathways for mucin production

D. Recent Areas of Study
• EGFR Signaling Pathways
• Modulation of proinflammatory responses
• Viral infections
• CFTR and its role in inflammatory airway diseases
• Bronchiolitis Obliterans Syndrome following lung transplantation

Education
Fellowship, 1960 - University of California, San Francisco, Cardiovascular Research Institute
Internship, 1954 - Philadelphia General Hospital, Philadelphia, PA, Philadelphia General Hospital
MD, 1953 - Jefferson Medical College, Philadelphia, PA, Jefferson
Honors and Awards
  • Distinguished Scientist Honor Lecture in Cardiopulmonary Physiology and Distinguished Service Award, CHEST, Los Angeles, CA, 2016
  • Honorary Lecture, 65th Annual Meeting of Japanese Society of Allergology (JSA), Japanese Society of Allergology (JSA), Tokyo, Japan, 2016
  • The Nadel Honorary Pulmonary Symposium, University of California San Francisco School of Medicine, 2015
  • Honorary Fellow, European Respiratory Society, 2014
  • Honorary Lecture in Lung Research, Karolinska Institute, Stockholm, 2013
  • Invited Lecture, XIII National Conference of the Italian Union of Pneumology, Catania, Italy, 2012
  • Invited Lecture, 7th International Symposium on Cough, National Heart and Lung Institute, Imperial College, London, UK, 2012
  • John Widdicombe Memorial Lecture, 7th International Symposium on Cough, National Heart and Lung Institute, Imperial College, London, UK, 2012
  • Special Lecturer, Chest Meeting, Airways Network, Hawaii, 2011
  • Honorary Lecturer, Japanese Respiratory Society, Tokyo, 2011
  • Honorary Lecturer, Transatlantic Airway Conference 25th Anniversary, Lucerne, 2010
  • René Descartes Medal, University of Paris, 2008
  • Honorary Jerome I. Kleinerman Annual Lecture, Case Western Reserve University School of Medicine, Cleveland, 2005
  • First Annual Honorary Joseph R. Rodarte Lectureship in Pulmonary Medicine, Baylor College of Medicine, 2002
  • Festschrift Honoring Prof. Gert Kunkel, Free University of Berlin, 2002
  • Honorary Member Associazione Nicolo Copernico Alumni Dell Ateneo Estense, University of Ferrara, Italy, 2002
  • Best Doctors of San Francisco Bay Area Nomination, 1999
  • Best Doctors of America Nomination, 1998
  • Alumni Achievement Award, JH Coley Lectureship, Jefferson Medical College, Philadelphia, 1998
  • Trudeau Medal, American Thoracic Society, 1997
  • Honorary Degree in Law, Dickinson Law School, Carlisle, PA, 1997
  • Honorary Doctorate of Medicine, University of Lund, Sweden, 1996
  • Honorary Membership, Finnish Association of Pulmonary Physicians, 1994
  • Honorary Membership, Society for Lung and Airway Research, German Society of Pulmonology, 1994
  • Medal of the University, University of Helsinki, 1994
  • Amberson Lecturer, American Thoracic Society, San Francisco, 1993
  • Crocker Clean Air Award (for outstanding research in Air Pollution), American Lung Association, 1992
  • Distinguished Achievement Award, Ben Gurion University, 1992
  • Sam J. Sills Honorary Lectureship, University of Southern California, 1992
  • Giles S. Filley Lecture, Aspen Lung Conferences, 1991
  • Honorary Doctorate of Medicine, University of Ferrara, Ferrara, Italy, 1991
  • Pfizer Visiting Professor, Royal Society of Medicine Foundation, 1990
  • Kass Lectureship and Medalist, University of Nebraska School of Medicine, 1990
  • Distinguished Lecturer, The Ninth William P. Buffum Oration, Brown University School of Medicine, 1989
  • Distinguished Lecturer in Physiology, American College of Chest Physicians, 1987
  • California Medal, American Lung Association of California, 1984
  • Clean Air Award, American Lung Association of California, 1984
  • Honorary Membership, California Thoracic Society, 1984
  • Visiting Scientist, Hammersmith Hospital, London, England, 1973
  • Visiting Scientist, University Laboratory of Physiology, University of Oxford, Oxford, England, 1962
  • Giannini Research Fellow, Cardiovascular Research Institute, University of California, San Francisco, 1960-1961
  • Blockley Award for Outstanding Publication, Philadelphia General Hospital, 1955
  • Medical Practice Prize, Jefferson Medical College, 1953
Publications

  1. Masson VK, Nussbaum E, Gelb AF, Tashkin DP, Randhawa I, Nadel JA, Fireizen Y, De Celie-Germana JK, Madera D, Senanayake D. Isolated abnormal FEF75% detects unsuspected bronchiolar obstruction in CF children. Pediatric research 2023. PMID: 36914809


  2. Gelb AF, Yamamoto A, Verbeken EK, Hogg JC, Tashkin DP, Tran DNT, Moridzadeh RM, Fraser C, Schein MJ, Decramer M, Glassy EF, Nadel JA. Normal Routine Spirometry Can Mask COPD/Emphysema in Symptomatic Smokers. 2021. PMID: 33513660


  3. Gelb AF, Yamamoto A, Verbeken E, Grigorian SR, Nadel JA. Asthma Emphysema Overlap in Non-Smokers. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2020. PMID: 32791102


  4. Gelb AF, Yamamoto A, Verbeken EK, Schein MJ, Moridzadeh R, Tran D, Fraser C, Barbers R, Elatre W, Koss MN, Glassy EF, Nadel JA. Further Studies of Unsuspected Emphysema in Nonsmoking Patients With Asthma With Persistent Expiratory Airflow Obstruction. Volume 153 of Issue 3. Chest 2017. PMID: 29197547


  5. Gelb AF, Nadel JA. Affirmation of the adoration of the vagi and role of tiotropium in asthmatic patients. Volume 138 of Issue 4. The Journal of allergy and clinical immunology 2016. PMID: 27527265


  6. Gelb AF, Christenson SA, Nadel JA. Understanding the pathophysiology of the asthma-chronic obstructive pulmonary disease overlap syndrome. Volume 22 of Issue 2. Current opinion in pulmonary medicine 2016. PMID: 26717511


  7. Gelb AF, Nadel JA. Understanding the pathophysiology of the asthma-chronic obstructive pulmonary disease overlap syndrome. Volume 136 of Issue 3. The Journal of allergy and clinical immunology 2015. PMID: 26343939


  8. Gelb AF, Yamamoto A, Verbeken EK, Nadel JA. Unraveling the Pathophysiology of the Asthma-COPD Overlap Syndrome: Unsuspected Mild Centrilobular Emphysema Is Responsible for Loss of Lung Elastic Recoil in Never Smokers With Asthma With Persistent Expiratory Airflow Limitation. Volume 148 of Issue 2. Chest 2015. PMID: 25950858


  9. Kalinowski A, Ueki I, Min-Oo G, Ballon-Landa E, Knoff D, Galen B, Lanier LL, Nadel JA, Koff JL. EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production. Volume 307 of Issue 2. American journal of physiology. Lung cellular and molecular physiology 2014. PMID: 24838750


  10. Nadel JA. The CFTR and EGFR relationship in airway vascular growth, and its importance in cystic fibrosis. Volume 42 of Issue 6. The European respiratory journal 2013. PMID: 24293414


  11. Gelb AF, Yamamoto A, Mauad T, Kollin J, Schein MJ, Nadel JA. Unsuspected mild emphysema in nonsmoking patients with chronic asthma with persistent airway obstruction. Volume 133 of Issue 1. The Journal of allergy and clinical immunology 2013. PMID: 24290280


  12. Ueki IF, Min-Oo G, Kalinowski A, Ballon-Landa E, Lanier LL, Nadel JA, Koff JL. Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon ? and antiviral defense in airway epithelium. Volume 210 of Issue 10. The Journal of experimental medicine 2013. PMID: 23999497


  13. Kim S, Beyer BA, Lewis C, Nadel JA. Normal CFTR inhibits epidermal growth factor receptor-dependent pro-inflammatory chemokine production in human airway epithelial cells. Volume 8 of Issue 8. PloS one 2013. PMID: 23977375


  14. Chung KF, Nadel JA, Fontana G. John Widdicombe's contribution to respiratory physiology and cough: reminiscences. Volume 9 of Issue 1. Cough (London, England) 2013. PMID: 23497652


  15. Nadel JA. Mucous hypersecretion and relationship to cough. Volume 26 of Issue 5. Pulmonary pharmacology & therapeutics 2013. PMID: 23434445


  16. Kim S, Lewis C, Nadel JA. Epidermal growth factor receptor reactivation induced by E-prostanoid-3 receptor- and tumor necrosis factor-alpha-converting enzyme-dependent feedback exaggerates interleukin-8 production in airway cancer (NCI-H292) cells. Volume 317 of Issue 18. Experimental cell research 2011. PMID: 21925169


  17. Kim S, Lewis C, Nadel JA. CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells. Volume 186 of Issue 6. Journal of immunology (Baltimore, Md. : 1950) 2011. PMID: 21300824


  18. Burgel PR, Nadel JA. Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases. Volume 32 of Issue 4. The European respiratory journal 2008. PMID: 18827153


  19. Koff JL, Shao MX, Ueki IF, Nadel JA. Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium. Volume 294 of Issue 6. American journal of physiology. Lung cellular and molecular physiology 2008. PMID: 18375743


  20. Nadel JA. Innate immune mucin production via epithelial cell surface signaling: relationship to allergic disease. Volume 7 of Issue 1. Current opinion in allergy and clinical immunology 2007. PMID: 17218812


  21. Koff JL, Shao MX, Kim S, Ueki IF, Nadel JA. Pseudomonas lipopolysaccharide accelerates wound repair via activation of a novel epithelial cell signaling cascade. Volume 177 of Issue 12. Journal of immunology (Baltimore, Md. : 1950) 2006. PMID: 17142770


  22. Shao MX, Nadel JA. Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme. Volume 175 of Issue 6. Journal of immunology (Baltimore, Md. : 1950) 2005. PMID: 16148149


  23. Shao MX, Nadel JA. Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells. Volume 102 of Issue 3. Proceedings of the National Academy of Sciences of the United States of America 2005. PMID: 15640347


  24. Nadel JA. COPD Role of the Airway Epithelium in Defense Against Inhaled Invaders 2005. PMID:


  25. Shao MX, Nakanaga T, Nadel JA. Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-alpha-converting enzyme in human airway epithelial (NCI-H292) cells. Volume 287 of Issue 2. American journal of physiology. Lung cellular and molecular physiology 2004. PMID: 15121636


  26. Shao MX, Ueki IF, Nadel JA. Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells. Volume 100 of Issue 20. Proceedings of the National Academy of Sciences of the United States of America 2003. PMID: 12972643


  27. Takeyama K, Dabbagh K, Lee HM, Agustí C, Lausier JA, Ueki IF, Grattan KM, Nadel JA. Epidermal growth factor system regulates mucin production in airways. Volume 96 of Issue 6. Proceedings of the National Academy of Sciences of the United States of America 1999. PMID: 10077640


  28. Nadel JA, Conrad DJ, Ueki IF, Schuster A, Sigal E. Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells. Volume 87 of Issue 4. The Journal of clinical investigation 1991. PMID: 2010530


  29. Vanderslice P, Craik CS, Nadel JA, Caughey GH. Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation. Volume 28 of Issue 10. Biochemistry 1989. PMID: 2504277


  30. Sommerhoff CP, Caughey GH, Finkbeiner WE, Lazarus SC, Basbaum CB, Nadel JA. Mast cell chymase. A potent secretagogue for airway gland serous cells. Volume 142 of Issue 7. Journal of immunology (Baltimore, Md. : 1950) 1989. PMID: 2494259


  31. Ueki I, German VF, Nadel JA. Micropipette measurement of airway submucosal gland secretion. Autonomic effects. Volume 121 of Issue 2. The American review of respiratory disease 1980. PMID: 7362142


  32. Hinchcliffe WA, Zamel N, Fishman NH, Dedo HH, Greenspan RH, Nadel J. Roentgenographic study of the human trachea with powdered tantalum. Volume 97 of Issue 2. Radiology 1970. PMID: 5481137


  33. Goldsmith JR, Nadel JA. Experimental exposure of human subjects to ozone. Volume 19 of Issue 5. Journal of the Air Pollution Control Association 1969. PMID: 5797492


  34. TOKIWA Y, TAMPLIN BR, NADEL JA. MONITORING HUMAN EXPOSURES TO SULFUR DIOXIDE IN A BODY PLETHYSMOGRAPH. Volume 15. Journal of the Air Pollution Control Association 1965. PMID: 14257517


  35. NADEL JA, COMROE JH. Acute effects of inhalation of cigarette smoke on airway conductance. Volume 16. Journal of applied physiology 1961. PMID: 13727341