Joel Karliner, MD

Prof of Medicine Emeritus

Education
Clinical Fellowship, - School of Medicine - Cardiology, University of California, San Francisco
Websites
Publications

  1. Goetzl EJ, Goetzl L, Karliner JS, Tang N, Pulliam L. Human plasma platelet-derived exosomes: effects of aspirin. Volume 30 of Issue 5. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016. PMID: 26873936


  2. Luk FS, Kim RY, Li K, Ching D, Wong DK, Joshi SK, Imhof I, Honbo N, Hoover H, Zhu BQ, Lovett DH, Karliner JS, Raffai RL. Immunosuppression With FTY720 Reverses Cardiac Dysfunction in Hypomorphic ApoE Mice Deficient in SR-BI Expression That Survive Myocardial Infarction Caused by Coronary Atherosclerosis. Volume 67 of Issue 1. Journal of cardiovascular pharmacology 2016. PMID: 26322923


  3. Yeghiazarians Y, Honbo N, Imhof I, Woods B, Aguilera V, Ye J, Boyle AJ, Karliner JS. IL-15: a novel prosurvival signaling pathway in cardiomyocytes. Journal of cardiovascular pharmacology 2014. PMID: 24805144


  4. Karliner JS. Arsonists and firefighters: the perpetual inflammatory civil war for survival. Volume 129 of Issue 23. Circulation 2014. PMID: 24710031


  5. Karliner JS. Selected aspects of cellular responses in heart failure. Volume 63 of Issue 2. Journal of cardiovascular pharmacology 2014. PMID: 24390177


  6. Wang G, Kim RY, Imhof I, Honbo N, Luk FS, Li K, Kumar N, Zhu BQ, Eberlé D, Ching D, Karliner JS, Raffai RL. The immunosuppressant FTY720 prolongs survival in a mouse model of diet-induced coronary atherosclerosis and myocardial infarction. Volume 63 of Issue 2. Journal of cardiovascular pharmacology 2014. PMID: 24508946


  7. Lovett DH, Mahimkar R, Raffai RL, Cape L, Zhu BQ, Jin ZQ, Baker AJ, Karliner JS. N-terminal truncated intracellular matrix metalloproteinase-2 induces cardiomyocyte hypertrophy, inflammation and systolic heart failure. Volume 8 of Issue 7. PloS one 2013. PMID: 23874529


  8. Kawabori M, Kacimi R, Karliner JS, Yenari MA. Sphingolipids in cardiovascular and cerebrovascular systems: Pathological implications and potential therapeutic targets. Volume 5 of Issue 4. World journal of cardiology 2013. PMID: 23675553


  9. Vessey DA, Li L, Imhof I, Honbo N, Karliner JS. FTY720 postconditions isolated perfused heart by a mechanism independent of sphingosine kinase 2 and different from S1P or ischemic postconditioning. Volume 19. Medical science monitor basic research 2013. PMID: 23567658


  10. Karliner JS. Sphingosine kinase and sphingosine 1-phosphate in the heart: a decade of progress. Volume 1831 of Issue 1. Biochimica et biophysica acta 2012. PMID: 22735359


  11. Lovett DH, Mahimkar R, Raffai RL, Cape L, Maklashina E, Cecchini G, Karliner JS. A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity. Volume 7 of Issue 4. PloS one 2012. PMID: 22509276


  12. Bauerly K, Harris C, Chowanadisai W, Graham J, Havel PJ, Tchaparian E, Satre M, Karliner JS, Rucker RB. Altering pyrroloquinoline quinone nutritional status modulates mitochondrial, lipid, and energy metabolism in rats. Volume 6 of Issue 7. PloS one 2011. PMID: 21814553


  13. Vessey DA, Li L, Jin ZQ, Kelley M, Honbo N, Zhang J, Karliner JS. A sphingosine kinase form 2 knockout sensitizes mouse myocardium to ischemia/reoxygenation injury and diminishes responsiveness to ischemic preconditioning. Volume 2011. Oxidative medicine and cellular longevity 2011. PMID: 21904650


  14. Bandhuvula P, Honbo N, Wang GY, Jin ZQ, Fyrst H, Zhang M, Borowsky AD, Dillard L, Karliner JS, Saba JD. S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart. Volume 300 of Issue 5. American journal of physiology. Heart and circulatory physiology 2011. PMID: 21335477


  15. Tao R, Kim SH, Honbo N, Karliner JS, Alano CC. Minocycline protects cardiac myocytes against simulated ischemia–reperfusion injury by inhibiting poly(ADP-ribose) polymerase-1. Volume 56 of Issue 6. Journal of cardiovascular pharmacology 2010. PMID: 20881608


  16. Dahi S, Karliner JS, Sarkar R, Lovett DH. Transgenic expression of matrix metalloproteinase-2 induces coronary artery ectasia. Volume 92 of Issue 1. International journal of experimental pathology 2010. PMID: 21039989


  17. Zhang J, Chatterjee K, Alano CC, Kalinowski MA, Honbo N, Karliner JS. Vincristine attenuates N-methyl-N'-nitro-N-nitrosoguanidine-induced poly-(ADP) ribose polymerase activity in cardiomyocytes. Volume 55 of Issue 3. Journal of cardiovascular pharmacology 2010. PMID: 20375713


  18. Tao R, Hoover HE, Honbo N, Kalinowski M, Alano CC, Karliner JS, Raffai R. High-density lipoprotein determines adult mouse cardiomyocyte fate after hypoxia-reoxygenation through lipoprotein-associated sphingosine 1-phosphate. Volume 298 of Issue 3. American journal of physiology. Heart and circulatory physiology 2010. PMID: 20061542


  19. Kotlyar AB, Randazzo A, Honbo N, Jin ZQ, Karliner JS, Cecchini G. Cardioprotective activity of a novel and potent competitive inhibitor of lactate dehydrogenase. Volume 584 of Issue 1. FEBS letters 2010. PMID: 19913538


  20. Chatterjee K, Zhang J, Honbo N, Karliner JS. Doxorubicin cardiomyopathy. Volume 115 of Issue 2. Cardiology 2009. PMID: 20016174


  21. Karliner JS. Lessons from the besotted heart. Volume 54 of Issue 23. Journal of the American College of Cardiology 2009. PMID: 19942092


  22. Vessey DA, Li L, Honbo N, Karliner JS. Sphingosine 1-phosphate is an important endogenous cardioprotectant released by ischemic pre- and postconditioning. Volume 297 of Issue 4. American journal of physiology. Heart and circulatory physiology 2009. PMID: 19648253


  23. Tao R, Hoover HE, Zhang J, Honbo N, Alano CC, Karliner JS. Cardiomyocyte S1P1 receptor-mediated extracellular signal-related kinase signaling and desensitization. Volume 53 of Issue 6. Journal of cardiovascular pharmacology 2009. PMID: 19433984


  24. Li H, Malhotra D, Yeh CC, Tu R, Zhu BQ, Birger N, Wisneski A, Cha J, Karliner JS, Mann MJ. Myocardial survival signaling in response to stem cell transplantation. Volume 208 of Issue 4. Journal of the American College of Surgeons 2009. PMID: 19476797


  25. Karliner JS, Brown JH. Lipid signalling in cardiovascular pathophysiology. Volume 82 of Issue 2. Cardiovascular research 2009. PMID: 19297369


  26. Karliner JS. Sphingosine kinase and sphingosine 1-phosphate in cardioprotection. Volume 53 of Issue 3. Journal of cardiovascular pharmacology 2009. PMID: 19247197


  27. Yeh CC, Li H, Malhotra D, Huang MC, Zhu BQ, Goetzl EJ, Vessey DA, Karliner JS, Mann MJ. Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarction. Volume 296 of Issue 4. American journal of physiology. Heart and circulatory physiology 2009. PMID: 19234089


  28. Karliner JS. Sphingosine kinase regulation and cardioprotection. Volume 82 of Issue 2. Cardiovascular research 2008. PMID: 19017750


  29. Mahimkar R, Nguyen A, Mann M, Yeh CC, Zhu BQ, Karliner JS, Lovett DH. Cardiac transgenic matrix metalloproteinase-2 expression induces myxomatous valve degeneration: a potential model of mitral valve prolapse disease. Volume 18 of Issue 5. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2008. PMID: 18835790


  30. Vessey DA, Li L, Kelley M, Karliner JS. Combined sphingosine, S1P and ischemic postconditioning rescue the heart after protracted ischemia. Volume 375 of Issue 3. Biochemical and biophysical research communications 2008. PMID: 18706887


  31. Chatterjee K, Zhang J, Tao R, Honbo N, Karliner JS. Vincristine attenuates doxorubicin cardiotoxicity. Volume 373 of Issue 4. Biochemical and biophysical research communications 2008. PMID: 18590705


  32. Jin ZQ, Karliner JS, Vessey DA. Ischaemic postconditioning protects isolated mouse hearts against ischaemia/reperfusion injury via sphingosine kinase isoform-1 activation. Volume 79 of Issue 1. Cardiovascular research 2008. PMID: 18334546


  33. Vessey DA, Li L, Kelley M, Zhang J, Karliner JS. Sphingosine can pre- and post-condition heart and utilizes a different mechanism from sphingosine 1-phosphate. Volume 22 of Issue 2. Journal of biochemical and molecular toxicology 2008. PMID: 18418901


  34. Alano CC, Tran A, Tao R, Ying W, Karliner JS, Swanson RA. Differences among cell types in NAD(+) compartmentalization: a comparison of neurons, astrocytes, and cardiac myocytes. Volume 85 of Issue 15. Journal of neuroscience research 2007. PMID: 17853438


  35. McCloskey DT, Turcato S, Wang GY, Turnbull L, Zhu BQ, Bambino T, Nguyen AP, Lovett DH, Nissenson RA, Karliner JS, Baker AJ. Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy. Volume 294 of Issue 1. American journal of physiology. Heart and circulatory physiology 2007. PMID: 17965283


  36. Grivennikova VG, Kotlyar AB, Karliner JS, Cecchini G, Vinogradov AD. Redox-dependent change of nucleotide affinity to the active site of the mammalian complex I. Volume 46 of Issue 38. Biochemistry 2007. PMID: 17760425


  37. Zhang J, Honbo N, Goetzl EJ, Chatterjee K, Karliner JS, Gray MO. Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxia. Volume 293 of Issue 5. American journal of physiology. Heart and circulatory physiology 2007. PMID: 17766476


  38. Tao R, Karliner JS, Simonis U, Zheng J, Zhang J, Honbo N, Alano CC. Pyrroloquinoline quinone preserves mitochondrial function and prevents oxidative injury in adult rat cardiac myocytes. Volume 363 of Issue 2. Biochemical and biophysical research communications 2007. PMID: 17880922


  39. Bao X, Lu CM, Liu F, Gu Y, Dalton ND, Zhu BQ, Foster E, Chen J, Karliner JS, Ross J, Simpson PC, Ziegler MG. Epinephrine is required for normal cardiovascular responses to stress in the phenylethanolamine N-methyltransferase knockout mouse. Circulation 2007. PMID: 17698731


  40. Chatterjee K, Zhang J, Honbo N, Simonis U, Shaw R, Karliner JS. Acute vincristine pretreatment protects adult mouse cardiac myocytes from oxidative stress. Volume 43 of Issue 3. Journal of molecular and cellular cardiology 2007. PMID: 17662302


  41. Jin ZQ, Zhang J, Huang Y, Hoover HE, Vessey DA, Karliner JS. A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury. Volume 76 of Issue 1. Cardiovascular research 2007. PMID: 17610857


  42. Zhou HZ, Ma X, Gray MO, Zhu BQ, Nguyen AP, Baker AJ, Simonis U, Cecchini G, Lovett DH, Karliner JS. Transgenic MMP-2 expression induces latent cardiac mitochondrial dysfunction. Volume 358 of Issue 1. Biochemical and biophysical research communications 2007. PMID: 17475219


  43. Kacimi R, Vessey DA, Honbo N, Karliner JS. Adult cardiac fibroblasts null for sphingosine kinase-1 exhibit growth dysregulation and an enhanced proinflammatory response. Volume 43 of Issue 1. Journal of molecular and cellular cardiology 2007. PMID: 17512943


  44. Tao R, Zhang J, Vessey DA, Honbo N, Karliner JS. Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes. Volume 74 of Issue 1. Cardiovascular research 2007. PMID: 17320845


  45. Vessey DA, Kelley M, Zhang J, Li L, Tao R, Karliner JS. Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart. Volume 21 of Issue 5. Journal of biochemical and molecular toxicology 2007. PMID: 17912702


  46. Bergman MR, Teerlink JR, Mahimkar R, Li L, Zhu BQ, Nguyen A, Dahi S, Karliner JS, Lovett DH. Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction. Volume 292 of Issue 4. American journal of physiology. Heart and circulatory physiology 2006. PMID: 17158653


  47. Vessey DA, Kelley M, Li L, Huang Y, Zhou HZ, Zhu BQ, Karliner JS. Role of sphingosine kinase activity in protection of heart against ischemia reperfusion injury. Volume 12 of Issue 10. Medical science monitor : international medical journal of experimental and clinical research 2006. PMID: 17006394


  48. Karliner JS. Toward solving the riddle: the enigma becomes less mysterious. Volume 99 of Issue 5. Circulation research 2006. PMID: 16946142


  49. Jin ZQ, Karliner JS. Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism. Volume 71 of Issue 4. Cardiovascular research 2006. PMID: 16831409


  50. Zhu BQ, Simonis U, Cecchini G, Zhou HZ, Li L, Teerlink JR, Karliner JS. Comparison of pyrroloquinoline quinone and/or metoprolol on myocardial infarct size and mitochondrial damage in a rat model of ischemia/reperfusion injury. Journal of cardiovascular pharmacology and therapeutics 2006. PMID: 16891289


  51. Alfonso-Jaume MA, Bergman MR, Mahimkar R, Cheng S, Jin ZQ, Karliner JS, Lovett DH. Cardiac ischemia-reperfusion injury induces matrix metalloproteinase-2 expression through the AP-1 components FosB and JunB. Volume 291 of Issue 4. American journal of physiology. Heart and circulatory physiology 2006. PMID: 16699069


  52. Turnbull L, Zhou HZ, Swigart PM, Turcato S, Karliner JS, Conklin BR, Simpson PC, Baker AJ. Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator. Volume 290 of Issue 3. American journal of physiology. Heart and circulatory physiology 2005. PMID: 16243914


  53. Wang GY, Bergman MR, Nguyen AP, Turcato S, Swigart PM, Rodrigo MC, Simpson PC, Karliner JS, Lovett DH, Baker AJ. Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility. Volume 69 of Issue 3. Cardiovascular research 2005. PMID: 16183043


  54. Kotlyar AB, Karliner JS, Cecchini G. A novel strong competitive inhibitor of complex I. Volume 579 of Issue 21. FEBS letters 2005. PMID: 16107251


  55. Karliner JS. Off the shelf but not mass produced. Volume 12 of Issue 6. Chemistry & biology 2005. PMID: 15975506


  56. Karliner JS. Symbols within words: have we neglected the AdeNOsine A2 receptor? Volume 65 of Issue 4. Cardiovascular research 2005. PMID: 15721853


  57. Vessey DA, Kelley M, Karliner JS. A rapid radioassay for sphingosine kinase. Volume 337 of Issue 1. Analytical biochemistry 2005. PMID: 15649386


  58. Jin ZQ, Zhou HZ, Cecchini G, Gray MO, Karliner JS. MnSOD in mouse heart: acute responses to ischemic preconditioning and ischemia-reperfusion injury. Volume 288 of Issue 6. American journal of physiology. Heart and circulatory physiology 2005. PMID: 15681709


  59. Zhu BQ, Zhou HZ, Teerlink JR, Karliner JS. Pyrroloquinoline quinone (PQQ) decreases myocardial infarct size and improves cardiac function in rat models of ischemia and ischemia/reperfusion. Cardiovascular drugs and therapy 2004. PMID: 15770429


  60. Jin ZQ, Goetzl EJ, Karliner JS. Sphingosine kinase activation mediates ischemic preconditioning in murine heart. Volume 110 of Issue 14. Circulation 2004. PMID: 15451787


  61. Karliner JS. Mechanisms of cardioprotection by lysophospholipids. Volume 92 of Issue 6. Journal of cellular biochemistry 2004. PMID: 15258895


  62. Chi NC, Karliner JS. Molecular determinants of responses to myocardial ischemia/reperfusion injury: focus on hypoxia-inducible and heat shock factors. Volume 61 of Issue 3. Cardiovascular research 2004. PMID: 14962475


  63. Maklashina E, Kotlyar AB, Karliner JS, Cecchini G. Effect of oxygen on activation state of complex I and lack of oxaloacetate inhibition of complex II in Langendorff perfused rat heart. Volume 556 of Issue 1-3. FEBS letters 2004. PMID: 14706827


  64. Zhu BQ, Heeschen C, Sievers RE, Karliner JS, Parmley WW, Glantz SA, Cooke JP. Second hand smoke stimulates tumor angiogenesis and growth. Volume 4 of Issue 3. Cancer cell 2003. PMID: 14522253


  65. Graeler MH, Kong Y, Karliner JS, Goetzl EJ. Protein kinase C epsilon dependence of the recovery from down-regulation of S1P1 G protein-coupled receptors of T lymphocytes. Volume 278 of Issue 30. The Journal of biological chemistry 2003. PMID: 12782628


  66. Zhu BQ, Sievers RE, Browne AE, Lee RJ, Chatterjee K, Grossman W, Karliner JS, Parmley WW. Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function. Volume 4 of Issue 1. Journal of the renin-angiotensin-aldosterone system : JRAAS 2003. PMID: 12692751


  67. Bergman MR, Cheng S, Honbo N, Piacentini L, Karliner JS, Lovett DH. A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers. Volume 369 of Issue Pt 3. The Biochemical journal 2003. PMID: 12371906


  68. Maklashina E, Sher Y, Zhou HZ, Gray MO, Karliner JS, Cecchini G. Effect of anoxia/reperfusion on the reversible active/de-active transition of NADH-ubiquinone oxidoreductase (complex I) in rat heart. Volume 1556 of Issue 1. Biochimica et biophysica acta 2002. PMID: 12351213


  69. Zhou HZ, Karliner JS, Gray MO. Moderate alcohol consumption induces sustained cardiac protection by activating PKC-epsilon and Akt. American journal of physiology. Heart and circulatory physiology 2002. PMID: 12063287


  70. Jin ZQ, Zhou HZ, Zhu P, Honbo N, Mochly-Rosen D, Messing RO, Goetzl EJ, Karliner JS, Gray MO. Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts. Volume 282 of Issue 6. American journal of physiology. Heart and circulatory physiology 2002. PMID: 12003800


  71. Karliner JS. Lysophospholipids and the cardiovascular system. Biochimica et biophysica acta 2002. PMID: 12069831