Mallar Bhattacharya, MD

Associate Professor

Dr. Bhattacharya is an attending ICU physician at UCSF Medical Center and directs a research laboratory at the Parnassus Heights campus. His lab focuses on lung injury and fibrosis, both major health problems for which effective therapies are limited, and is developing novel approaches to the study of cell-cell interactions in the lung--for example, between immune and structural cells. These interactions drive the development of scarring and progressive loss of lung function and therefore represent an opportunity for discovery of novel therapies.

Education
2019 - Diversity, Equity, and Inclusion Champion Training, University of California
B.A., - , Harvard University
M.D., - , Harvard University
Residency, - Internal Medicine, Johns Hopkins Hospital
M.Sc., - , Oxford University
Fellowship, - Pulmonary and Critical Care, University of California, San Francisco
Websites
Publications

  1. Yadav P, Ortega JG, Tamaki W, Chien C, Chang KC, Biswas N, Pan S, Nilsson J, Yin X, Bhattacharyya A, Boostanpour K, Jujaray T, Wang J, Tsukui T, Sheppard D, Li B, Maishan M, Taenaka H, Matthay MA, Muramatsu R, Maliskova L, Ghosh A, Eckalbar WL, Molofsky AB, Wolters PJ, Tamaki SJ, Bivona T, Abate AR, Wagner A, Tharp KM, Bhattacharya M. Macrophage-fibroblast crosstalk drives Arg1-dependent lung fibrosis via ornithine loading. bioRxiv : the preprint server for biology 2024. PMID: 39211079


  2. Bhattacharyya A, Khan R, Lee JY, Tassew G, Oskouian B, Allende ML, Proia RL, Yin X, Ortega JG, Bhattacharya M, Saba JD. Gene therapy with AAV9-SGPL1 in an animal model of lung fibrosis. The Journal of pathology 2024. PMID: 38332723


  3. Bhattacharya M. Hard CiDRE revs up macrophage infectivity in COVID-19. Immunity 2023. PMID: 37557078


  4. Bhattacharya M, Ramachandran P. Immunology of human fibrosis. Nature immunology 2023. PMID: 37474654


  5. Bhattacharya M. Insights from Transcriptomics: CD163+ Profibrotic Lung Macrophages in COVID-19. 2022. PMID: 35675555


  6. Bhattacharyya A, Torre P, Yadav P, Boostanpour K, Chen TY, Tsukui T, Sheppard D, Muramatsu R, Seed RI, Nishimura SL, Jung JB, Tang XZ, Allen CDC, Bhattacharya M. Macrophage Cx43 Is Necessary for Fibroblast Cytosolic Calcium and Lung Fibrosis After Injury. 2022. PMID: 35634278


  7. Bhattacharyya A, Boostanpour K, Bouzidi M, Magee L, Chen TY, Wolters R, Torre P, Pillai SK, Bhattacharya M. IL10 trains macrophage pro-fibrotic function after lung injury. 2022. PMID: 35107021


  8. Lee S, Islam MN, Boostanpour K, Aran D, Jin G, Christenson S, Matthay MA, Eckalbar WL, DePianto DJ, Arron JR, Magee L, Bhattacharya S, Matsumoto R, Kubota M, Farber DL, Bhattacharya J, Wolters PJ, Bhattacharya M. Molecular programs of fibrotic change in aging human lung. 2021. PMID: 34728633


  9. Arora S, Thompson PJ, Wang Y, Bhattacharyya A, Apostolopoulou H, Hatano R, Naikawadi RP, Shah A, Wolters PJ, Koliwad S, Bhattacharya M, Bhushan A. Invariant Natural Killer T cells coordinate removal of senescent cells. 2021. PMID: 34617070


  10. Alam Z, Devalaraja S, Li M, To TKJ, Folkert IW, Mitchell-Velasquez E, Dang MT, Young P, Wilbur CJ, Silverman MA, Li X, Chen YH, Hernandez PT, Bhattacharyya A, Bhattacharya M, Levine MH, Haldar M. Counter Regulation of Spic by NF-κB and STAT Signaling Controls Inflammation and Iron Metabolism in Macrophages. Cell reports 2020. PMID: 32610126


  11. Looney AP, Bhattacharya M. Fibroblast Gap-closure Assay-Microscopy-based in vitro Assay Measuring the Migration of Murine Fibroblasts. Bio-protocol 2019. PMID: 31531389


  12. Aran D, Looney AP, Liu L, Wu E, Fong V, Hsu A, Chak S, Naikawadi RP, Wolters PJ, Abate AR, Butte AJ, Bhattacharya M. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nature immunology 2019. PMID: 30643263


  13. Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD, Prakash YS, Bhattacharya M. Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice. JCI insight 2018. PMID: 30385725


  14. Bhattacharya M. Could a coffee a day keep the inflammasome away? Science translational medicine 2017. PMID: 28179502


  15. Bhattacharya M. Mesenchymal metamorphosis. Science translational medicine 2016. PMID: 28003541


  16. Mallar Bhattacharya. Macrophages build a wall and the host pays for it. 2016. PMID:


  17. Mallar Bhattacharya. Stiff discipline for cells in pulmonary hypertension. Science translational medicine 2016. PMID:


  18. Mallar Bhattacharya. Airway architect Adam33 in asthma. Science translational medicine 2016. PMID:


  19. Mallar Bhattacharya. The gut takes a “Toll” on the lung. Science translational medicine 2016. PMID:


  20. Mallar Bhattacharya. Unwanted guests: Bacterial microbiome in COPD. Science translational medicine 2016. PMID:


  21. Mallar Bhattacharya. H5N1 stems the alveolar tide: MSCs to the rescue!. Science translational medicine 2016. PMID:


  22. Bhattacharya M, Kallet RH, Ware LB, Matthay MA. Negative-Pressure Pulmonary Edema. Chest 2016. PMID: 27063348


  23. Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D. IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction. Volume 124 of Issue 11. The Journal of clinical investigation 2014. PMID: 25271629


  24. Su G, Atakilit A, Li JT, Wu N, Luong J, Chen R, Bhattacharya M, Sheppard D. Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin avß5. Volume 41 of Issue 2. Critical care medicine 2013. PMID: 23263571


  25. Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay MA, Sheppard D. IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia. Volume 303 of Issue 1. American journal of physiology. Lung cellular and molecular physiology 2012. PMID: 22561460


  26. Su G, Atakilit A, Li JT, Wu N, Bhattacharya M, Zhu J, Shieh JE, Li E, Chen R, Sun S, Su CP, Sheppard D. Absence of integrin avß3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation. Volume 185 of Issue 1. American journal of respiratory and critical care medicine 2012. PMID: 21980034


  27. Mallar Bhattacharya, Michael A. Matthay, Hamid Rabb. CHAPTER 188 Acute Respiratory Distress Syndrome and the Kidney: Lung and Kidney Crosstalk. 2009. PMID:


  28. Mallar Bhattacharya, Benjamin M. Yeh, Aliya Qayyum, Fergus V. Coakley. Case 81. Radiology 2004. PMID:


  29. Sigle RO, Gil SG, Bhattacharya M, Ryan MC, Yang TM, Brown TA, Boutaud A, Miyashita Y, Olerud J, Carter WG. Globular domains 4/5 of the laminin alpha3 chain mediate deposition of precursor laminin 5. Journal of cell science 2004. PMID: 15316072