Mark Looney, MD

Professor In Residence

Mark R. Looney, MD is a Professor of Medicine and Laboratory Medicine and Attending Physician on the Pulmonary Consult Service and the Intensive Care Units at UCSF. He received his undergraduate degree from Lipscomb University in Nashville, Tennessee in 1994 and his medical degree from the University of Tennessee, Memphis in 1998. He then came to UCSF where he completed his residency in Internal Medicine, a fellowship in Pulmonary and Critical Care Medicine, and research training in the Cardiovascular Research Institute.

Research Interests

My lab is broadly focused on innate immune biology in the lung. Thematic areas include neutrophil and platelet biology as applied to a variety of pulmonary disease states including acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), primary graft dysfunction after lung transplantation, and cystic fibrosis. A major interest is the application of multiphoton intravital lung microscopy as a discovery tool to aid in the study of lung biology, including novel studies on the role of the pulmonary circulation in platelet biogenesis and the hematopoietic potential of the lung. Our overall goal is to identify new mechanisms responsible for lung inflammation and injury and to develop novel therapies to combat lung disease.

Education
Residency, 2001 - Internal Medicine, University of California, San Francisco
M.D., 1998 - School of Medicine, University of Tennessee
Honors and Awards
  • Elected Member, Association of American Physicians, 2018
  • Elected Member, American Society for Clinical Investigation, 2013
  • Jean Julliard Prize, International Society of Blood Transfusion (ISBT), 2010
  • Carl Booberg Research Award, American Thoracic Society, 2008
  • Alpha Omega Alpha, University of Tennessee, 1997
Websites
Publications

  1. Tsao T, Qiu L, Bharti R, Shemesh A, Hernandez AM, Cleary SJ, Greenland NY, Santos J, Shi R, Bai L, Richardson J, Dilley K, Will M, Tomasevic N, Sputova T, Salles A, Kang J, Zhang D, Hays SR, Kukreja J, Singer JP, Lanier LL, Looney MR, Greenland JR, Calabrese DR. CD94+ Natural Killer cells potentiate pulmonary ischemia-reperfusion injury. The European respiratory journal 2024. PMID: 39190789


  2. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Bernard O, Simoneau CR, Hysenaj L, Hu KH, Maishan M, Conrad C, Gbenedio OM, Samad B, Consortium TUC, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Immediate myeloid depot for SARS-CoV-2 in the human lung. Science advances 2024. PMID: 39083602


  3. Chen S, Looney MR. Understanding megakaryocyte phenotypes and the impact on platelet biogenesis. Transfusion 2024. PMID: 38923572


  4. Simon J. Cleary, Mark R. Looney. Reply: The importance of disrupting complement activation in acute lung injury. Journal of Clinical Investigation 2024. PMID:


  5. Pandey A, Chopra S, Cleary SJ, López-Álvarez M, Quimby FM, Alanizi AAA, Sakhamuri S, Zhang N, Looney MR, Craik CS, Wilson DM, Evans MJ. Imaging the Granzyme Mediated Host Immune Response to Viral and Bacterial Pathogens In Vivo Using Positron Emission Tomography. ACS infectious diseases 2024. PMID: 38819300


  6. Moussavi-Harami SF, Cleary SJ, Magnen M, Seo Y, Conrad C, English BC, Qiu L, Wang KM, Abram CL, Lowell CA, Looney MR. Loss of neutrophil Shp1 produces hemorrhagic and lethal acute lung injury. bioRxiv : the preprint server for biology 2024. PMID: 38854059


  7. T. Tsao, L. Qiu, A. Shemesh, A. Millan Hernandez, K. Shi, J. Richardson, R. Bharti, J. Santos, L. Lanier, M. Looney, J. Greenland, D.R. Calabrese. (225) Novel Anti-CD94 Treatment Reduces Mouse and Human Experimental Pulmonary Ischemia-Reperfusion Injury. The Journal of Heart and Lung Transplantation 2024. PMID:


  8. Cleary SJ, Seo Y, Tian JJ, Kwaan N, Bulkley DP, Bentlage AEH, Vidarsson G, Boilard É, Spirig R, Zimring JC, Looney MR. IgG hexamers initiate complement-dependent acute lung injury. The Journal of clinical investigation 2024. PMID: 38530369


  9. Looney M, Conrad C, Magnen M, Tsui J, Wismer H, Naser M, Venkataramani U, Samad B, Cleary S, Qiu L, Tian J, De Giovanni M, Mende N, Passegue E, Laurenti E, Combes A. Functional haematopoietic progenitor cells in the adult human lung. Research square 2023. PMID: 38077002


  10. Cleary SJ, Seo Y, Tian JJ, Kwaan N, Bulkley DP, Bentlage AEH, Vidarsson G, Boilard É, Spirig R, Zimring JC, Looney MR. IgG hexamers initiate acute lung injury. bioRxiv : the preprint server for biology 2024. PMID: 38328049


  11. Aguilar OA, Qualls AE, Gonzalez-Hinojosa MDR, Obeidalla S, Kerchberger VE, Tsao T, Singer JP, Looney MR, Raymond W, Hays SR, Golden JA, Kukreja J, Shaver CM, Ware LB, Christie J, Diamond JM, Lanier LL, Greenland JR, Calabrese DR, LTOG Investigators. MICB Genomic Variant is Associated with NKG2D-mediated Acute Lung Injury and Death. American journal of respiratory and critical care medicine 2023. PMID: 37878820


  12. Santos J, Wang P, Shemesh A, Liu F, Tsao T, Aguilar OA, Cleary SJ, Singer JP, Gao Y, Hays SR, Golden J, Leard LE, Kleinhenz ME, Kolaitis NA, Shah RJ, Venado A, Kukreja J, Weigt SS, Belperio JA, Lanier LL, Looney MR, Greenland JR, Calabrese DR. CCR5 drives NK cell-associated airway damage in pulmonary ischemia-reperfusion injury. JCI insight 2023. PMID: 37788115


  13. M Sorrells, Y Seo, M Magnen, R Sheybani, A M Shah, H T Tse, M R Looney, H O'Neal. B-075 Biophysical Changes of Leukocyte Activation (and NETosis) in the Cellular Host Response to Sepsis. Clinical chemistry 2023. PMID:


  14. Seo Y, Qiu L, Magnen M, Conrad C, Moussavi-Harami SF, Looney MR, Cleary SJ. Optimizing anesthesia and delivery approaches for dosing into lungs of mice. American journal of physiology. Lung cellular and molecular physiology 2023. PMID: 37401383


  15. Seo Y, Qiu L, Magnen M, Conrad C, Moussavi-Harami SF, Looney MR, Cleary SJ. Optimizing anesthesia and delivery approaches for dosing into lungs of mice. bioRxiv : the preprint server for biology 2023. PMID: 36778478


  16. Sorrells MG, Seo Y, Magnen M, Broussard B, Sheybani R, Shah AM, O'Neal HR, Tse HTK, Looney MR, Di Carlo D. Biophysical Changes of Leukocyte Activation (and NETosis) in the Cellular Host Response to Sepsis. Diagnostics (Basel, Switzerland) 2023. PMID: 37189536


  17. J. Santos, S. Cleary, P. Wang, A. Shemesh, T. Tsao, E. Aminian, M.R. Looney, J.R. Greenland, D.R. Calabrese. CCR5 Mediates Natural Killer Cell Airway Trafficking in Lung Ischemia Reperfusion Injury. The Journal of Heart and Lung Transplantation 2023. PMID:


  18. Hysenaj L, Little S, Kulhanek K, Magnen M, Bahl K, Gbenedio OM, Prinz M, Rodriguez L, Andersen C, Rao AA, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Mick E, Khalid MM, Taha TY, Kumar R, Li JZ, Ding VW, Matsumoto S, Maishan M, Sreekumar B, Simoneau C, Nazarenko I, Tomlinson MG, Khan K, von Gottberg A, Sigal A, Looney MR, Fragiadakis GK, Jablons DM, Langelier CR, Matthay M, Krummel M, Erle DJ, Combes AJ, Sil A, Ott M, Kratz JR, Roose JP. SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants. Stem cell reports 2023. PMID: 36827975


  19. Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, Tian JJ, Aminian EA, Wang KM, Shemesh A, Punzalan EB, Sarma A, Calfee CS, Christenson SA, Langelier CR, Hays SR, Golden JA, Leard LE, Kleinhenz ME, Kolaitis NA, Shah RJ, Venado A, Lanier LL, Greenland JR, Sayah DM, Ardehali A, Kukreja J, Weigt SS, Belperio JA, Singer JP, Looney MR. NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes. JCI insight 2022. PMID: 36346670


  20. Conrad C, Looney MR. Is neutrophilic inflammation treatable in COVID-19? The Lancet. Respiratory medicine 2022. PMID: 36075244


  21. Martin TR, Zemans RL, Ware LB, Schmidt EP, Riches DWH, Bastarache L, Calfee CS, Desai TJ, Herold S, Hough CL, Looney MR, Matthay MA, Meyer N, Parikh SM, Stevens T, Thompson BT. New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021. 2022. PMID: 35679511


  22. Looney M, Magnen M, You R, Rao A, Davis R, Rodriguez L, Simoneau C, Hysenaj L, Hu K, Love C, Woodruff P, Erle D, Hendrickson C, Calfee C, Matthay M, Roose J, Sil A, Ott M, Langelier C, Krummel M. Immediate myeloid depot for SARS-CoV-2 in the human lung. 2022. PMID: 35611333


  23. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Immediate myeloid depot for SARS-CoV-2 in the human lung. 2022. PMID: 35592107


  24. Toy P, Looney MR, Popovsky M, Palfi M, Berlin G, Chapman CE, Bolton-Maggs P, Matthay MA. Transfusion-Related Acute Lung Injury: 36 years of Progress (1985-2021). 2022. PMID: 35045272


  25. D.R. Calabrese, J.P. Singer, S.R. Hays, L.E. Leard, J.A. Golden, N.A. Kolaitis, M. Kleinhenz, R. Shah, A. Venado, J. Kukreja, J.A. Belperio, S.S. Weigt, J.R. Greenland, M.R. Looney. Bronchoalveolar Lavage MICB is Associated with Severe Primary Graft Dysfunction, Prolonged Mechanical Ventilation, and Low Post-Transplant FEV1 in Lung Transplant Recipients. The Journal of Heart and Lung Transplantation 2022. PMID:


  26. Valet C, Magnen M, Qiu L, Cleary SJ, Wang KM, Ranucci S, Grockowiak E, Boudra R, Conrad C, Seo Y, Calabrese DR, Greenland JR, Leavitt AD, Passegué E, Mendez-Ferrer S, Swirski FK, Looney MR. Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression. 2022. PMID: 35192546


  27. De Giovanni M, Tam H, Valet C, Xu Y, Looney MR, Cyster JG. GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA. 2022. PMID: 35303424


  28. Liu D, Duan L, Rodda LB, Lu E, Xu Y, An J, Qiu L, Liu F, Looney MR, Yang Z, Allen CDC, Li Z, Marson A, Cyster JG. CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells. 2022. PMID: 35143305


  29. De Giovanni M, Tam H, Valet C, Xu Y, Looney MR, Cyster JG. GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA. 2022. PMID: 35148838


  30. Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin SC, Aljohmani A, Moussavi-Harami SF, Wang KM, Tian JJ, Magnen M, Valet C, Qiu L, Singer JP, Eltzschig HK, CAPSys Study Group, Bertrams W, Herold S, Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR, Bartsch JW. ADAM8 signaling drives neutrophil migration and ARDS severity. 2022. PMID: 35132956


  31. Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM, Altemeier WA, Artigas A, Bates JHT, Calfee CS, Dela Cruz CS, Dickson RP, Englert JA, Everitt JI, Fessler MB, Gelman AE, Gowdy KM, Groshong SD, Herold S, Homer RJ, Horowitz JC, Hsia CCW, Kurahashi K, Laubach VE, Looney MR, Lucas R, Mangalmurti NS, Manicone AM, Martin TR, Matalon S, Matthay MA, McAuley DF, McGrath-Morrow SA, Mizgerd JP, Montgomery SA, Moore BB, Noël A, Perlman CE, Reilly JP, Schmidt EP, Skerrett SJ, Suber TL, Summers C, Suratt BT, Takata M, Tuder R, Uhlig S, Witzenrath M, Zemans RL, Matute-Bello G. Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report. 2022. PMID: 35103557


  32. Zhao N, Bardine C, Lourenço AL, Wang YH, Huang Y, Cleary SJ, Wilson DM, Oh DY, Fong L, Looney MR, Evans MJ, Craik CS. In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET. 2021. PMID: 34729407


  33. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium , Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19. Nature 2021. PMID: 34341540


  34. Deuse T, Tediashvili G, Hu X, Gravina A, Tamenang A, Wang D, Connolly A, Mueller C, Mallavia B, Looney MR, Alawi M, Lanier LL, Schrepfer S. Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice. Proceedings of the National Academy of Sciences of the United States of America 2021. PMID: 34244428


  35. E. Aminian, B. Mallavia, F. Liu, S. Cleary, P. Wang, J.P. Singer, S.R. Hays, J.A. Golden, J. Kukreja, D. Dugger, M. Nakamura, L.L. Lanier, M.R. Looney, J.R. Greenland, D.R. Calabrese. Natural Killer Cells Recognize Pulmonary Epithelial Stress Molecules during Primary Graft Dysfunction. The Journal of Heart and Lung Transplantation 2021. PMID:


  36. Cleary SJ, Looney MR. Chewing the fat on TRALI. Blood 2021. PMID: 33538806


  37. Calabrese DR, Aminian E, Mallavia B, Liu F, Cleary SJ, Aguilar OA, Wang P, Singer JP, Hays SR, Golden JA, Kukreja J, Dugger D, Nakamura M, Lanier LL, Looney MR, Greenland JR. Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury. The Journal of clinical investigation 2021. PMID: 33290276


  38. Hilt ZT, Maurya P, Tesoro L, Pariser DN, Ture SK, Cleary SJ, Looney MR, McGrath KE, Morrell CN. β2M Signals Monocytes Through Non-Canonical TGFβ Receptor Signal Transduction. Circulation research 2021. PMID: 33508948


  39. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium , Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. Global absence and targeting of protective immune states in severe COVID-19. Nature 2021. PMID: 33494096


  40. Pariser DN, Hilt ZT, Ture SK, Blick-Nitko SK, Looney MR, Cleary SJ, Roman-Pagan E, Saunders Ii J, Georas SN, Veazey JM, Madere F, Tesoro Santos L, Arne AM, Huynh NP, Livada AC, Guerrero-Martin SM, Lyons CE, Metcalf Pate KA, McGrath KE, Palis J, Morrell C. Lung megakaryocytes are immune modulatory cells. The Journal of clinical investigation 2020. PMID: 33079726


  41. Hyun YM, Seo SU, Choi WS, Kwon HJ, Kim DY, Jeong S, Kang GY, Yi E, Kim M, Ryu HJ, Looney MR, Choi EY, Kim HS. Endogenous DEL-1 restrains melanoma lung metastasis by limiting myeloid cell-associated lung inflammation. Science advances 2020. PMID: 33158867


  42. Cleary SJ, Kwaan N, Tian JJ, Calabrese DR, Mallavia B, Magnen M, Greenland JR, Urisman A, Singer JP, Hays SR, Kukreja J, Hay AM, Howie HL, Toy P, Lowell CA, Morrell CN, Zimring JC, Looney MR. Complement activation on endothelium initiates antibody-mediated acute lung injury. The Journal of clinical investigation 2020. PMID: 32730229


  43. Cleary SJ, Magnen M, Looney MR, Page CP. Update on animal models for COVID-19 research. British journal of pharmacology 2020. PMID: 33140409


  44. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. Global Absence and Targeting of Protective Immune States in Severe COVID-19. bioRxiv : the preprint server for biology 2020. PMID: 33140050


  45. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. Global Absence and Targeting of Protective Immune States in Severe COVID-19. Research square 2020. PMID: 33140041


  46. Zhao Y, Magaña LC, Cui H, Huang J, McHale CM, Yang X, Looney MR, Li R, Zhang L. Formaldehyde-induced hematopoietic stem and progenitor cell toxicity in mouse lung and nose. Archives of toxicology 2020. PMID: 33084937


  47. Roubinian NH, Chowdhury D, Hendrickson JE, Triulzi DJ, Gottschall JL, Looney MR, Matthay MA, Kor DJ, Brambilla D, Kleinman SH, Murphy EL. NT-proBNP levels in the identification and classification of pulmonary transfusion reactions. Transfusion 2020. PMID: 32905629


  48. Cleary SJ, Pitchford SC, Amison RT, Carrington R, Robaina Cabrera CL, Magnen M, Looney MR, Gray E, Page CP. Animal models of mechanisms of SARS-CoV-2 infection and COVID-19 pathology. British journal of pharmacology 2020. PMID: 32462701


  49. Barnes BJ, Adrover JM, Baxter-Stoltzfus A, Borczuk A, Cools-Lartigue J, Crawford JM, Daßler-Plenker J, Guerci P, Huynh C, Knight JS, Loda M, Looney MR, McAllister F, Rayes R, Renaud S, Rousseau S, Salvatore S, Schwartz RE, Spicer JD, Yost CC, Weber A, Zuo Y, Egeblad M. Targeting potential drivers of COVID-19: Neutrophil extracellular traps. The Journal of experimental medicine 2020. PMID: 32302401


  50. Ortiz-Munoz G, Yu MA, Lefrançais E, Mallavia B, Valet C, Tian JJ, Ranucci S, Wang KM, Liu Z, Kwaan N, Dawson D, Kleinhenz ME, Khasawneh FT, Haggie PM, Verkman AS, Looney MR. Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation. The Journal of clinical investigation 2020. PMID: 31961827


  51. Mallavia B, Liu F, Lefrançais E, Cleary SJ, Kwaan N, Tian JJ, Magnen M, Sayah DM, Soong A, Chen J, Saggar R, Shino MY, Ross DJ, Derhovanessian A, Lynch Iii JP, Ardehali A, Weigt SS, Belperio JA, Hays SR, Golden JA, Leard LE, Shah RJ, Kleinhenz ME, Venado A, Kukreja J, Singer JP, Looney MR. Mitochondrial DNA Stimulates TLR9-Dependent NET Formation in Primary Graft Dysfunction. American journal of respiratory cell and molecular biology 2019. PMID: 31647878


  52. Lefrançais E, Looney MR. Platelet Biogenesis in the Lung Circulation. Physiology (Bethesda, Md.) 2019. PMID: 31577166


  53. Qu J, Prasad NK, Yu MA, Chen S, Lyden A, Herrera N, Silvis MR, Crawford E, Looney MR, Peters JM, Rosenberg OS. Modulating pathogenesis with Mobile-CRISPRi. Journal of bacteriology 2019. PMID: 31481541


  54. Cleary SJ, Hobbs C, Amison RT, Arnold S, O'Shaughnessy BG, Lefrançais E, Mallavia B, Looney MR, Page CP, Pitchford SC. LPS-Induced Lung Platelet Recruitment Occurs Independently from Neutrophils, PSGL-1, and P-selectin. American journal of respiratory cell and molecular biology 2019. PMID: 30768917


  55. Vlaar APJ, Toy P, Fung M, Looney MR, Juffermans NP, Bux J, Bolton-Maggs P, Peters AL, Silliman CC, Kor DJ, Kleinman S. An update of the transfusion-related acute lung injury (TRALI) definition. Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine 2019. PMID: 31221537


  56. Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Fajt ML, Wenzel SE, Israel E, Levy BD, Fahy JV. Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma. American journal of respiratory and critical care medicine 2019. PMID: 30888839


  57. Vlaar APJ, Toy P, Fung M, Looney MR, Juffermans NP, Bux J, Bolton-Maggs P, Peters AL, Silliman CC, Kor DJ, Kleinman S. A consensus redefinition of transfusion-related acute lung injury. Transfusion 2019. PMID: 30993745


  58. Looney MR, Headley MB. Live imaging of the pulmonary immune environment. Cellular immunology 2018. PMID: 30336937


  59. Looney MR. The incomparable platelet: holy alveoli! Blood 2018. PMID: 30213837


  60. Bergmeier W, Antoniak S, Conway EM, Denis CV, George LA, Isermann B, Key NS, Krishnaswamy S, Lam WA, Lillicrap D, Liu J, Looney MR, López JA, Maas C, Peyvandi F, Ruf W, Sood AK, Versteeg HH, Wolberg AS, Wong PC, Wood JP, Weiler H. Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis. Research and practice in thrombosis and haemostasis 2018. PMID: 30046746


  61. Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Michalkiewicz M, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL. Contemporary Risk Factors and Outcomes of Transfusion-Associated Circulatory Overload. Critical care medicine 2018. PMID: 29300236


  62. Lefrançais E, Mallavia B, Zhuo H, Calfee CS, Looney MR. Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury. JCI insight 2018. PMID: 29415887


  63. Lefrançais E, Looney MR. Neutralizing Extracellular Histones in Acute Respiratory Distress Syndrome. A New Role for an Endogenous Pathway. American journal of respiratory and critical care medicine 2017. PMID: 28707972


  64. Mallavia B, Kwaan N, Marschner S, Yonemura S, Looney MR. Mirasol pathogen reduction technology treatment of human whole blood does not induce acute lung injury in mice. PloS one 2017. PMID: 28570672


  65. Lama VN, Belperio JA, Christie JD, El-Chemaly S, Fishbein MC, Gelman AE, Hancock WW, Keshavjee S, Kreisel D, Laubach VE, Looney MR, McDyer JF, Mohanakumar T, Shilling RA, Panoskaltsis-Mortari A, Wilkes DS, Eu JP, Nicolls MR. Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop. JCI insight 2017. PMID: 28469087


  66. Roubinian NH, Looney MR, Keating S, Kor DJ, Lowell CA, Gajic O, Hubmayr R, Gropper M, Koenigsberg M, Wilson GA, A Matthay M, Toy P, Murphy EL. Differentiating pulmonary transfusion reactions using recipient and transfusion factors. Transfusion 2017. PMID: 28470756


  67. Yipp BG, Kim JH, Lima R, Zbytnuik LD, Petri B, Swanlund N, Ho M, Szeto VG, Tak T, Koenderman L, Pickkers P, Tool ATJ, Kuijpers TW, van den Berg TK, Looney MR, Krummel MF, Kubes P. The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection. Science immunology 2017. PMID: 28626833


  68. Santhosh L, Babik J, Looney MR, Hollander H. Whither the Pulmonary Ward Attending? Preserving Subspecialty Exposure in United States Internal Medicine Residency Training. Annals of the American Thoracic Society 2017. PMID: 28362539


  69. Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, Krummel MF, Leavitt AD, Passegué E, Looney MR. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Volume 544 of Issue 7648. Nature 2017. PMID: 28329764


  70. Hamid U, Krasnodembskaya A, Fitzgerald M, Shyamsundar M, Kissenpfennig A, Scott C, Lefrancais E, Looney MR, Verghis R, Scott J, Simpson AJ, McNamee J, McAuley DF, O'Kane CM. Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS. Thorax 2017. PMID: 28082531


  71. Emma Lefrançais, Beñat Mallavia, Mark R. Looney. Lung Imaging in Animal Models. 2017. PMID:


  72. Panka BA, de Grooth HJ, Spoelstra-de Man AM, Looney MR, Tuinman PR. Prevention or Treatment of Ards With Aspirin: A Review of Preclinical Models and Meta-Analysis of Clinical Studies. Shock (Augusta, Ga.) 2017. PMID: 27984533


  73. Toy P, Kleinman SH, Looney MR. Proposed revised nomenclature for transfusion-related acute lung injury. Transfusion 2016. PMID: 28019007


  74. Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL. Incidence and clinical characteristics of transfusion-associated circulatory overload using an active surveillance algorithm. Vox sanguinis 2016. PMID: 28001313


  75. Rossaint J, Kühne K, Skupski J, Van Aken H, Looney MR, Hidalgo A, Zarbock A. Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response. Nature communications 2016. PMID: 27845343


  76. Chong SZ, Evrard M, Devi S, Chen J, Lim JY, See P, Zhang Y, Adrover JM, Lee B, Tan L, Li JL, Liong KH, Phua C, Balachander A, Boey A, Liebl D, Tan SM, Chan JK, Balabanian K, Harris JE, Bianchini M, Weber C, Duchene J, Lum J, Poidinger M, Chen Q, Rénia L, Wang CI, Larbi A, Randolph GJ, Weninger W, Looney MR, Krummel MF, Biswas SK, Ginhoux F, Hidalgo A, Bachelerie F, Ng LG. CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses. The Journal of experimental medicine 2016. PMID: 27811056


  77. Henry TS, Naeger DM, Looney MR, Elicker BM. Dyspnea and Pulmonary Hypertension with Diffuse Centrilobular Nodules. Annals of the American Thoracic Society 2016. PMID: 27726440


  78. Naikawadi RP, Disayabutr S, Mallavia B, Donne ML, Green G, La JL, Rock JR, Looney MR, Wolters PJ. Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis. JCI insight 2016. PMID: 27699234


  79. Ram Naikawadi, Supparerk Disayabutr, Benat Mallavia, Matthew Donne, Gary Green, Jason Rock, Mark Looney, Paul Wolters. P131 Telomere Dysfunction in Alveolar Epithelial Cells Causes Pulmonary Fibrosis: Role for TRF1. QJM 2016. PMID:


  80. Toy P, Kleinman SH, Looney MR. Reply to concerns regarding dropping the term "possible TRALI". Transfusion 2016. PMID: 27624212


  81. Headley MB, Bins A, Nip A, Roberts EW, Looney MR, Gerard A, Krummel MF. Visualization of immediate immune responses to pioneer metastatic cells in the lung. Nature 2016. PMID: 26982733


  82. Mallavia B, Liu F, Sheppard D, Looney MR. Inhibiting Integrin avß5 Reduces Ischemia-Reperfusion Injury in an Orthotopic Lung Transplant Model in Mice. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2016. PMID: 26602748


  83. M. R. Looney. Current concepts in TRALI pathogenesis. ISBT Science Series 2016. PMID:


  84. Caudrillier A, Mallavia B, Rouse L, Marschner S, Looney MR. Transfusion of Human Platelets Treated with Mirasol Pathogen Reduction Technology Does Not Induce Acute Lung Injury in Mice. PloS one 2015. PMID: 26176623


  85. Looney MR. Selectin' for NETs. Blood 2015. PMID: 26160186


  86. Ortiz-Muñoz G, Looney MR. Non-invasive Intratracheal Instillation in Mice. Bio-protocol 2015. PMID: 27390765


  87. Ortiz-Muñoz G, Looney MR. Two-event Transfusion-related Acute Lung Injury Mouse Model. Bio-protocol 2015. PMID: 29104887


  88. Sayah DM, Mallavia B, Looney MR. Reply: neutrophil extracellular traps in primary graft dysfunction after lung transplantation. American journal of respiratory and critical care medicine 2015. PMID: 25932769


  89. Bose O, Baluk P, Looney MR, Cheng LE, McDonald DM, Caughey GH, Krummel MF. Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice. Volume 10 of Issue 3. PloS one 2015. PMID: 25789765


  90. Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL. Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Transfusion 2015. PMID: 25702590


  91. Sayah DM, Mallavia B, Liu F, Ortiz-Muñoz G, Caudrillier A, DerHovanessian A, Ross DJ, Lynch JP, Saggar R, Ardehali A, Ware LB, Christie JD, Belperio JA, Looney MR. Neutrophil extracellular traps are pathogenic in primary graft dysfunction after lung transplantation. American journal of respiratory and critical care medicine 2015. PMID: 25485813


  92. Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature 2014. PMID: 25533958


  93. Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR. Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Transfusion 2014. PMID: 25488517


  94. Mark R. Looney. Platelets Induce Neutrophil Extracellular Traps in Transfusion-Related Acute Lung Injury. Blood 2014. PMID:


  95. Ortiz-Muñoz G, Mallavia B, Bins A, Headley M, Krummel MF, Looney MR. Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice. Blood 2014. PMID: 25143486


  96. Greenland JR, Xu X, Sayah DM, Liu FC, Jones KD, Looney MR, Caughey GH. Mast cells in a murine lung ischemia-reperfusion model of primary graft dysfunction. Volume 15. Respiratory research 2014. PMID: 25115556


  97. Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, Hirschler NV, Rosen RS, Matthay MA, Toy P. Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*. Critical care medicine 2014. PMID: 24776608


  98. Lelkes E, Headley MB, Thornton EE, Looney MR, Krummel MF. The spatiotemporal cellular dynamics of lung immunity. Trends in immunology 2014. PMID: 24974157


  99. Looney MR, Bhattacharya J. Live imaging of the lung. Annual review of physiology 2013. PMID: 24245941


  100. Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P. Risk factors and outcomes in transfusion-associated circulatory overload. The American journal of medicine 2013. PMID: 23357450


  101. Sayah DM, Looney MR, Toy P. Transfusion reactions: newer concepts on the pathophysiology, incidence, treatment, and prevention of transfusion-related acute lung injury. Critical care clinics 2012. PMID: 22713611


  102. Caudrillier A, Kessenbrock K, Gilliss BM, Nguyen JX, Marques MB, Monestier M, Toy P, Werb Z, Looney MR. Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. The Journal of clinical investigation 2012. PMID: 22684106


  103. Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF. Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. Volume 209 of Issue 6. The Journal of experimental medicine 2012. PMID: 22585735


  104. Thornton EE, Krummel MF, Looney MR. Live imaging of the lung. Current protocols in cytometry 2012. PMID: 22470155


  105. Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney MR, Lowell CA, Gropper MA. Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans. Anesthesia and analgesia 2012. PMID: 22262647


  106. Caudrillier A, Looney MR. Platelet-neutrophil interactions as a target for prevention and treatment of transfusion-related acute lung injury. Current pharmaceutical design 2012. PMID: 22621270


  107. Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA. Transfusion-related acute lung injury: incidence and risk factors. Blood 2011. PMID: 22117051


  108. Gilliss BM, Looney MR, Gropper MA. Reducing noninfectious risks of blood transfusion. Anesthesiology 2011. PMID: 21792054


  109. Emily Thornton, Mark Looney, Debasish Sen, Dean Sheppard, Xiaozhu Huang, Matthew Krummel. Lung surveillance revealed by two-photon live imaging (103.3). The Journal of Immunology 2011. PMID:


  110. Kleinman SH, Triulzi DJ, Murphy EL, Carey PM, Gottschall JL, Roback JD, Carrick D, Mathew S, Wright DJ, Cable R, Ness P, Gajic O, Hubmayr RD, Looney MR, Kakaiya RM. The Leukocyte Antibody Prevalence Study-II (LAPS-II): a retrospective cohort study of transfusion-related acute lung injury in recipients of high-plasma-volume human leukocyte antigen antibody-positive or -negative components. Transfusion 2011. PMID: 21446938


  111. Su X, Looney MR, Su HE, Lee JW, Song Y, Matthay MA. Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2011. PMID: 21301926


  112. Gilliss BM, Looney MR. Experimental models of transfusion-related acute lung injury. Transfusion medicine reviews 2011. PMID: 21134622


  113. Looney MR, Thornton EE, Sen D, Lamm WJ, Glenny RW, Krummel MF. Stabilized imaging of immune surveillance in the mouse lung. Nature methods 2010. PMID: 21151136


  114. Looney MR, Gilliss BM, Matthay MA. Pathophysiology of transfusion-related acute lung injury. Current opinion in hematology 2010. PMID: 20601870


  115. Miniati D, Jelin EB, Ng J, Wu J, Carlson TR, Wu X, Looney MR, Wang RA. Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice. American journal of physiology. Lung cellular and molecular physiology 2009. PMID: 19933399


  116. Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. The Journal of clinical investigation 2009. PMID: 19809160


  117. Liu KD, Looney MR, Matthay MA. Inhaled activated protein C: a novel therapy for acute lung injury? Critical care (London, England) 2009. PMID: 19519935


  118. Su X, Looney MR, Gupta N, Matthay MA. Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. American journal of physiology. Lung cellular and molecular physiology 2009. PMID: 19411309


  119. Looney MR, Matthay MA. Neutrophil sandwiches injure the microcirculation. Nature medicine 2009. PMID: 19350004


  120. Looney MR, Esmon CT, Matthay MA. Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury. Thorax 2008. PMID: 19008297


  121. Looney MR. Acute lung injury after blood product transfusion: are the times changing? Critical care medicine 2008. PMID: 18520657


  122. Su X, Johansen M, Looney MR, Brown EJ, Matthay MA. CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia. Journal of immunology (Baltimore, Md. : 1950) 2008. PMID: 18453616


  123. Looney MR, Matthay MA. The role of protein C in sepsis. Current infectious disease reports 2007. PMID: 24395479


  124. Mark R Looney, Rebecca Barbeau, Andrea Barczak, Yuanyuan Xiao, Clifford A Lowell, David J Erle, Michael A Matthay. Microarray analysis of a mouse model of transfusion-related acute lung injury (TRALI) reveals prominent increased expression of neutrophil-derived chemokines. The FASEB Journal 2007. PMID:


  125. Looney MR. Newly recognized causes of acute lung injury: transfusion of blood products, severe acute respiratory syndrome, and avian influenza. Clinics in chest medicine 2006. PMID: 17085248


  126. Church GD, Price C, Sanchez R, Looney MR. Transfusion-related acute lung injury in the paediatric patient: Two case reports and a review of the literature. Transfusion medicine (Oxford, England) 2006. PMID: 16999757


  127. Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA. Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. The Journal of clinical investigation 2006. PMID: 16710475


  128. Looney MR, Matthay MA. Animal models of transfusion-related acute lung injury. Critical care medicine 2006. PMID: 16617257


  129. Looney MR, Matthay MA. Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury. Critical care (London, England) 2006. PMID: 17169139


  130. Looney MR, Sartori C, Chakraborty S, James PF, Lingrel JB, Matthay MA. Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance. American journal of physiology. Lung cellular and molecular physiology 2005. PMID: 15781423


  131. Su X, Looney M, Robriquet L, Fang X, Matthay MA. Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice. Experimental lung research 2004. PMID: 15524406


  132. Looney MR, Gropper MA, Matthay MA. Transfusion-related acute lung injury: a review. Chest 2004. PMID: 15249468


  133. Looney MR, Matthay MA. The Role of Protein C in Sepsis. Current infectious disease reports 2001. PMID: 11559461