Rena Fox, MD

Professor of Clinical Medicine

Dr. Rena Fox is a Professor of Clinical Medicine in the Department of Medicine, Division of General Internal Medicine since 2001. Dr. Fox was an undergraduate at Stanford, got her MD at UC San Diego and did her internal medicine residency at University of Washington. She was a general medicine clinician-educator fellow at UCSF with an interest in hepatitis C virus (HCV) during which time she was trained by UCSF hepatologists. Since then, her research has focused on improving the care of patients with liver disease. She studied the prevalence of HCV in the California prisons and was awarded the Jan Albrecht Award from AASLD. Her work includes studying electronic medical record strategies for improved HCV screening in primary care, cost-efficacy of DAA treatments, outcomes of cirrhosis and hepatocellular carcinoma (HCC), and algorithms for primary care providers to detect and risk stratify patients with NAFLD and advanced fibrosis. She worked with the VA for over a decade on creating HCV educational tools, national policies, and curriculum as medical editor for the VA Viral Hepatitis Website. As part of the CDC and DHHS Hepatitis Action Plan, she served as an editor for Hepatitis C Online, a curriculum for HCV education. She was a co-author and panel member of the clinical practice guidelines for the VA regarding the use of DAAs from 2013-2021. Dr. Fox is currently a voting panel member and the Chair of California Technology Assessment Forum (CTAF), a partner of the Institute for Clinical and Economic Review (ICER). CTAF is an independent panel of medical experts who works with ICER to evaluate the clinical and economic value of new drugs, across all fields. She also proves telemedicine consultation on HCV management for providers in underserved and rural areas for the UCSF Hepatitis C ECHO clinic. Dr. Fox is currently a member of the AASLD Foundations in Liver Disease Committee. She is Co-Chair of the SFCAN Liver Cancer Task Force, through the Cancer Center, bringing together multiple entities working to reduce the incidence and mortality of HCC and she is on the Executive Advisory Board for End Hep C SF. Examples of her university service include the UCSF and System-wide Committee on Committees (Chair, UCSF), the SOM Faculty Council, the DOM Promotions Subcommittee and the UC Primary Care Residency Selection committee. She was also asked to chair two UCSF Task Forces regarding the affiliations between UCSF and faith-based hospitals. Since then she has served as the Senate representative on the UCSF Health Leadership Council. She will serve a 3 year term as the UCSF representative for the UCOP Joint Clinical Advisory Committee on Covered Affiliations (2022-2025). In clinical practice, she maintains a busy and large primary care panel in General Medicine Practice at the Mt. Zion campus and for 19 years she was also the sole generalist practicing in the UCSF Viral Hepatitis Clinic. As an educator, she works with medical students and internal medicine residents and lectures nationally on liver disease, especially for primary care audiences.

Education
2018 - Diversity, Equity, and Inclusion Champion Training, University of California
Clinician-Educator Fellowship, 2001 - General Internal Medicine, UCSF
Internship and Residency, 2000 - Internal Medicine, University of Washington
M.D., 1997 - School of Medicine, University of California San Diego
Post-Baccalaureate, 1992 - , Bryn Mawr College
B.A., 1991 - Human Biology, Stanford University
Honors and Awards
  • UCSF Health Team PRIDE Award Winner for UCSF HCV Project ECHO, UCSF, 2019
  • Excellence in Teaching Award, The Haile T. Debas Academy of Medical Educators, UCSF Academy of Medical Educators, 2013
  • Robert H. Crede Award for Clinical Care, UCSF Division of General Internal Medicine, 2010
  • Top 10% Research Poster, EASL (European Association for the Study of the Liver), 2008
  • The Jan Albrecht Commitment to Clinical Research in Liver Diseases Award, AASLD, 2003
  • Outstanding Resident of the Year, Department of Medicine, University of Washington, 2000
Websites
Publications
  1. Choi HH, Kim S, Shum DJ, Huang CY, Shui A, Fox RK, Khalili M. Assessing Adherence to US LI-RADS Follow-up Recommendations in Vulnerable Patients Undergoing Hepatocellular Carcinoma Surveillance. Radiology. Imaging cancer 2024. PMID: 38214600


  2. Chu JN, Goldman ML, Brandman D, Sohn JH, Islam K, Ross LA, Fox RK. Underrecognition and Suboptimal Quality of Care for Nonalcoholic Fatty Liver Disease Cirrhosis in Primary Care Patients with Diabetes Mellitus. The American journal of medicine 2023. PMID: 37890572


  3. Fox RK, Chu JN, Goldman ML, Islam KB, Brandman D. Prospective study of a case-finding algorithm to detect NAFLD with advanced fibrosis in primary care patients. Hepatology communications 2023. PMID: 36724121


  4. Islam KB, Brandman D, Chu JN, Goldman ML, Fox RK. Primary Care Providers and Nonalcoholic Fatty Liver Disease: A Needs Assessment Survey. Digestive diseases and sciences 2022. PMID: 36178567


  5. Hiatt RA, Sibley A, Venkatesh B, Cheng J, Dixit N, Fox R, Ling P, Nguyen T, Oh D, Palmer NR, Pasick RJ, Potter MB, Somsouk M, Vargas RA, Vijayaraghavan M, Ashworth A. From Cancer Epidemiology to Policy and Practice: the Role of a Comprehensive Cancer Center. 2022. PMID: 35342686


  6. Mukhtar NA, Fox RK. Hepatitis C Virus Cure and Obesity: Watch the Weight. Journal of general internal medicine 2020. PMID: 32632793


  7. Zavala VA, Bracci PM, Carethers JM, Carvajal-Carmona L, Coggins NB, Cruz-Correa MR, Davis M, de Smith AJ, Dutil J, Figueiredo JC, Fox R, Graves KD, Gomez SL, Llera A, Neuhausen SL, Newman L, Nguyen T, Palmer JR, Palmer NR, Pérez-Stable EJ, Piawah S, Rodriquez EJ, Sanabria-Salas MC, Schmit SL, Serrano-Gomez SJ, Stern MC, Weitzel J, Yang JJ, Zabaleta J, Ziv E, Fejerman L. Cancer health disparities in racial/ethnic minorities in the United States. British journal of cancer 2020. PMID: 32901135


  8. Coffin PO, Santos GM, Behar E, Hern J, Walker J, Matheson T, Kinnard EN, Silvis J, Vittinghoff E, Fox R, Page K. Randomized feasibility trial of directly observed versus unobserved hepatitis C treatment with ledipasvir-sofosbuvir among people who inject drugs. PloS one 2019. PMID: 31158245


  9. Fox RK, Taddei TH, Kaplan DE. Aspirin Use and Risk of Hepatocellular Carcinoma in Hepatitis B. JAMA internal medicine 2019. PMID: 30882884


  10. Kaplan DE, Chapko MK, Mehta R, Dai F, Skanderson M, Aytaman A, Baytarian M, D'Addeo K, Fox R, Hunt K, Pocha C, Valderrama A, Taddei TH. Healthcare Costs Related to Treatment of Hepatocellular Carcinoma Among Veterans With Cirrhosis in the United States. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2017. PMID: 28756056


  11. Serper M, Taddei TH, Mehta R, D'Addeo K, Dai F, Aytaman A, Baytarian M, Fox R, Hunt K, Goldberg DS, Valderrama A, Kaplan DE. Association of Provider Specialty and Multidisciplinary Care With Hepatocellular Carcinoma Treatment and Mortality. Gastroenterology 2017. PMID: 28283421


  12. Goldberg DS, Taddei TH, Serper M, Mehta R, Dieperink E, Aytaman A, Baytarian M, Fox R, Hunt K, Pedrosa M, Pocha C, Valderrama A, Kaplan DE. Identifying barriers to hepatocellular carcinoma surveillance in a national sample of patients with cirrhosis. Hepatology (Baltimore, Md.) 2016. PMID: 27531119


  13. Kaplan DE, Dai F, Skanderson M, Aytaman A, Baytarian M, D'Addeo K, Fox R, Hunt K, Knott A, Mehta R, Pedrosa M, Pocha C, Valderrama A, Taddei T. Recalibrating the Child-Turcotte-Pugh Score to Improve Prediction of Transplant-Free Survival in Patients with Cirrhosis. Digestive diseases and sciences 2016. PMID: 27405990


  14. Fox RK, Muniraj T. Pharmacologic Therapies in Gastrointestinal Diseases. The Medical clinics of North America 2016. PMID: 27235617


  15. Chahal HS, Marseille EA, Tice JA, Pearson SD, Ollendorf DA, Fox RK, Kahn JG. Cost-effectiveness of Early Treatment of Hepatitis C Virus Genotype 1 by Stage of Liver Fibrosis in a US Treatment-Naive Population. JAMA internal medicine 2016. PMID: 26595724


  16. Kaplan DE, Dai F, Aytaman A, Baytarian M, Fox R, Hunt K, Knott A, Pedrosa M, Pocha C, Mehta R, Duggal M, Skanderson M, Valderrama A, Taddei TH. Development and Performance of an Algorithm to Estimate the Child-Turcotte-Pugh Score From a National Electronic Healthcare Database. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2015. PMID: 26188137


  17. Belperio PS, Fox RK, Backus LI. The State of Hepatitis C Care in the VA. Federal practitioner : for the health care professionals of the VA, DoD, and PHS 2015. PMID: 30766108


  18. Shah AD, Fox RK, Rushakoff RJ. Falsely Decreased HbA1c in a Type 2 Diabetic Patient Treated with Dapsone. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2014. PMID: 25100400


  19. Fox RK. When to consider liver transplant during the management of chronic liver disease. The Medical clinics of North America 2013. PMID: 24266919


  20. Fox RK. Hepatitis B--more treatments, more testing, not enough data. Journal of general internal medicine 2011. PMID: 21267669


  21. Bräu N, Fox RK, Xiao P, Marks K, Naqvi Z, Taylor LE, Trikha A, Sherman M, Sulkowski MS, Dieterich DT, Rigsby MO, Wright TL, Hernandez MD, Jain MK, Khatri GK, Sterling RK, Bonacini M, Martyn CA, Aytaman A, Llovet JM, Brown ST, Bini EJ. Presentation and outcome of hepatocellular carcinoma in HIV-infected patients: a U.S.-Canadian multicenter study. Journal of hepatology 2007. PMID: 17692986


  22. Fox RK, Currie SL, Evans J, Wright TL, Tobler L, Phelps B, Busch MP, Page-Shafer KA. Hepatitis C virus infection among prisoners in the California state correctional system. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005. PMID: 15983913


  23. Seligman HK, Fox RK. Treatment of acute hepatitis C with interferon alfa-2b. The New England journal of medicine 2002. PMID: 11936120