Roland Wu, MD

ASST CLIN PROF-VOL

I am a cardiologist and physician-scientist with board certifications in general cardiology and echocardiography. My clinical interest is in inpatient cardiology where I continue to practice.

Since 2020, my primary appointment has been with Amgen where I focus on leveraging human genetics and basic scientific insights to create clinically meaningful advances in cardiovascular medicine. My research focuses on understanding human cardiovascular disease by studying the genetics and gene regulation underlying these disorders, utilizing technologies such as in vivo genetic and enhancer screens coupled with computational biology.

Publications

  1. Zlatanova I, Sun F, Wu RS, Chen X, Lau BH, Colombier P, Sinha T, Celona B, Xu SM, Materna SC, Huang GN, Black BL. An injury-responsive mmp14b enhancer is required for heart regeneration. Science advances 2023. PMID: 38019918


  2. Engel JL, Zhang X, Lu DR, Vila OF, Arias V, Lee J, Hale C, Hsu YH, Li CM, Vedantham V, Ang YS. Single Cell Multi-Omics of an iPSC Model of Human Sinoatrial Node Development Reveals Genetic Determinants of Heart Rate and Arrhythmia Susceptibility. bioRxiv : the preprint server for biology 2023. PMID: 37425707


  3. Smith GA, Padmanabhan A, Lau BH, Pampana A, Li L, Lee CY, Pelonero A, Nishino T, Sadagopan N, Xia VQ, Jain R, Natarajan P, Wu RS, Black BL, Srivastava D, Shokat KM, Chorba JS. Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor. Science translational medicine 2022. PMID: 36103516


  4. Galang G, Mandla R, Ruan H, Jung C, Sinha T, Stone NR, Wu RS, Mannion BJ, Allu PK, Chang K, Rammohan A, Shi MB, Pennacchio LA, Black BL, Vedantham V. ATAC-seq Reveals an Isl1 Enhancer that Regulates Sinoatrial Node Development and Function. Circulation research 2020. PMID: 33044128


  5. Wu RS, Lam II, Clay H, Duong DN, Deo RC, Coughlin SR. A Rapid Method for Directed Gene Knockout for Screening in G0 Zebrafish. Developmental cell 2018. PMID: 29974860


  6. Zhang Q, Huang H, Zhang L, Wu R, Chung CI, Zhang SQ, Torra J, Schepis A, Coughlin SR, Kornberg TB, Shu X. Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter. Molecular cell 2018. PMID: 29351851


  7. Zhang Q, Huang H, Zhang L, Wu R, Chung CI, Zhang SQ, Torra J, Schepis A, Coughlin SR, Kornberg TB, Shu X. Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter. Molecular cell 2018. PMID: 29307513


  8. Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin SR, Jinek M, Pullinger CR, Kane JP, Hart DO, Kwok PY, Deo RC. An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish. eLife 2015. PMID: 26473617


  9. Nilsen DW, Mehran R, Wu RS, Yu J, Nordrehaug JE, Brodie BR, Witzenbichler B, Nikolsky E, Fahy M, Stone GW. Coronary reperfusion and clinical outcomes after thrombus aspiration during primary percutaneous coronary intervention: findings from the HORIZONS-AMI trial. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2013. PMID: 23074151


  10. Niu X, Liu G, Wu RS, Chudasama N, Zakharov SI, Karlin A, Marx SO. Orientations and proximities of the extracellular ends of transmembrane helices S0 and S4 in open and closed BK potassium channels. PloS one 2013. PMID: 23472181


  11. Wu RS, Liu G, Zakharov SI, Chudasama N, Motoike H, Karlin A, Marx SO. Positions of ß2 and ß3 subunits in the large-conductance calcium- and voltage-activated BK potassium channel. The Journal of general physiology 2013. PMID: 23277477


  12. Wu RS, Marx SO. The BK potassium channel in the vascular smooth muscle and kidney: a- and ß-subunits. Kidney international 2010. PMID: 20861815


  13. Liu G, Niu X, Wu RS, Chudasama N, Yao Y, Jin X, Weinberg R, Zakharov SI, Motoike H, Marx SO, Karlin A. Location of modulatory beta subunits in BK potassium channels. The Journal of general physiology 2010. PMID: 20385746


  14. Wu RS, Gupta S, Brown RN, Yancy CW, Wald JW, Kaiser P, Kirklin NM, Patel PC, Markham DW, Drazner MH, Garry DJ, Mammen PP. Clinical outcomes after cardiac transplantation in muscular dystrophy patients. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2009. PMID: 19864165


  15. Wu RS, Chudasama N, Zakharov SI, Doshi D, Motoike H, Liu G, Yao Y, Niu X, Deng SX, Landry DW, Karlin A, Marx SO. Location of the beta 4 transmembrane helices in the BK potassium channel. The Journal of neuroscience : the official journal of the Society for Neuroscience 2009. PMID: 19571123


  16. Liu G, Zakharov SI, Yang L, Wu RS, Deng SX, Landry DW, Karlin A, Marx SO. Locations of the beta1 transmembrane helices in the BK potassium channel. Proceedings of the National Academy of Sciences of the United States of America 2008. PMID: 18669652