Publications

Department of Medicine faculty members published more than 3,000 peer-reviewed articles in 2022.

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BMJ open

Accurate estimation of cardiovascular risk in a non-diabetic adult: detecting and correcting the error in the reported Framingham Risk Score for the Systolic Blood Pressure Intervention Trial population.

2018

Authors: Warner F, Dhruva SS, Ross JS, Dey P, Murugiah K, Krumholz HM

PloS one

Being Present: A single-arm feasibility study of audio-based mindfulness meditation for colorectal cancer patients and caregivers.

2018

Authors: Atreya CE, Kubo A, Borno HT, Rosenthal B, Campanella M, Rettger JP, Joseph G, Allen IE, Venook AP, Altschuler A, Dhruva A

JAMA

Trends in Use of Transcatheter Aortic Valve Replacement by Age.

2018

Authors: Sedrakyan A, Dhruva SS, Sun T, Mao J, Gaudino MFL, Redberg RF

Diabetes, obesity & metabolism

Outcomes of "diabetes-friendly" vs "diabetes-unfriendly" ß-blockers in older nursing home residents with diabetes after acute myocardial infarction.

2018

Authors: Zullo AR, Hersey M, Lee Y, Sharmin S, Bosco E, Daiello LA, Shah NR, Mor V, Boscardin WJ, Berard-Collins CM, Dore DD, Steinman MA

International journal of cardiology

Reduced global longitudinal strain is associated with increased risk of cardiovascular events or death after kidney transplant.

2018

Authors: Fujikura K, Peltzer B, Tiwari N, Shim HG, Dinhofer AB, Shitole SG, Kizer JR, Garcia MJ

JAMA neurology

Prevalence of Aging, Dementia, and Multimorbidity in Older Adults With Down Syndrome.

2018

Authors: Bayen E, Possin KL, Chen Y, Cleret de Langavant L, Yaffe K

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Increased Risk of Suicide Attempts and Unintended Death Among Those Transitioning From Prison to Community in Later Life.

2018

Authors: Barry LC, Steffens DC, Covinsky KE, Conwell Y, Li Y, Byers AL

American journal of kidney diseases : the official journal of the National Kidney Foundation

Effects of Body Size and Composition on Sex Differences in Measured GFR in a US Community-Based Older Cohort (MESA-Kidney).

2018

Authors: Abraham AG, Shafi T, Tighiouart H, Moseley KF, Post WS, Inker LA, Coresh J, Shlipak MG, Levey AS

The International journal of eating disorders

Disordered eating behaviors and cardiometabolic risk among young adults with overweight or obesity.

2018

Authors: Nagata JM, Garber AK, Tabler J, Murray SB, Vittinghoff E, Bibbins-Domingo K

Volume 361 of Issue 6399 | Science (New York, N.Y.)

Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells.

2018

Authors: Grevet JD, Lan X, Hamagami N, Edwards CR, Sankaranarayanan L, Ji X, Bhardwaj SK, Face CJ, Posocco DF, Abdulmalik O, Keller CA, Giardine B, Sidoli S, Garcia BA, Chou ST, Liebhaber SA, Hardison RC, Shi J, Blobel GA

View Abstract

Increasing fetal hemoglobin (HbF) levels in adult red blood cells provides clinical benefit to patients with sickle cell disease and some forms of β-thalassemia. To identify potentially druggable HbF regulators in adult human erythroid cells, we employed a protein kinase domain-focused CRISPR-Cas9-based genetic screen with a newly optimized single-guide RNA scaffold. The screen uncovered the heme-regulated inhibitor HRI (also known as EIF2AK1), an erythroid-specific kinase that controls protein translation, as an HbF repressor. HRI depletion markedly increased HbF production in a specific manner and reduced sickling in cultured erythroid cells. Diminished expression of the HbF repressor BCL11A accounted in large part for the effects of HRI depletion. Taken together, these results suggest HRI as a potential therapeutic target for hemoglobinopathies.

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