Publications

Department of Medicine faculty members published more than 3,000 peer-reviewed articles in 2022.

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Journal of cardiac failure

HFSA Expert Consensus Statement on the Medical Management of Patients on Durable Mechanical Circulatory Support.

2023

Authors: Trachtenberg B, Cowger J, Jennings DL, Grafton G, Loyaga-Rendon R, Cogswell R, Klein L, Shah P, Kiernan M, Vorovich E

Archives of osteoporosis

Correction to: Comparison of fracture risk assessment tools in older men without prior hip or spine fracture: the MrOS study.

2023

Authors: Gourlay ML, Ritter VS, Fine JP, Overman RA, Schousboe JT, Cawthon PM, Orwoll ES, Nguyen TV, Lane NE, Cummings SR, Kado DM, Lapidus JA, Diem SJ, Ensrud KE, Osteoporotic Fractures in Men (MrOS) Study Group

Expert opinion on drug safety

Safety implications of concomitant administration of antidepressants and opioid analgesics in surgical patients.

2023

Authors: Rodriguez-Monguio R, Lun Z, Dickinson DT, Do C, Hyland B, Kocharyan E, Liu L, Steinman MA

JAMA psychiatry

Association of Frailty With Risk of Suicide Attempt in a National Cohort of US Veterans Aged 65 Years or Older.

2023

Authors: Kuffel RL, Morin RT, Covinsky KE, Boscardin WJ, Lohman MC, Li Y, Byers AL

Acta oto-laryngologica

The relationship between serum lipid and sudden sensorineural hearing loss.

2023

Authors: Huang J, Xu Y, Li L, Ai W

Scientific Reports

Assessing the impact of one million COVID-19 deaths in America: economic and life expectancy losses.

2023

Authors: Silva S, Goosby E, Reid MJA

BMC public health

The value of the Nutrition and Obesity Policy Research and Evaluation Network in advancing the evidence base for effective nutrition and obesity policy: assessment using the Consolidated Framework for Collaborative Research.

2023

Authors: Vasquez T, Levi R, Akers M, Lowry-Warnock A, Blanck HM, Seligman H

BMC public health

Do precipitation anomalies influence short-term mobility in sub-saharan Africa? An observational study from 23 countries.

2023

Authors: Epstein A, Harris OO, Benmarhnia T, Camlin CS, Weiser SD

Annals of the American Thoracic Society

Medical Societies Must Choose Professional Meeting Locations Responsibly in a Post-Roe World.

2023

Authors: Lee AG, Maley J, Hibbert K, Akgün KM, Hauschildt KE, Law A, Kaminski N, Hayes M, Gesthalter Y, Bosslet GT, Santhosh L, Witkin A, Hills-Dunlap K, Çoruh B, Gershengorn HB, Hardin CC

Volume 11 | Frontiers in pediatrics

Prenatal exposure to opioids and neurodevelopment in infancy and childhood: A systematic review.

2023

Authors: Balalian AA, Graeve R, Richter M, Fink A, Kielstein H, Martins SS, Philbin MM, Factor-Litvak P

View Abstract

AIM

This systematic review aims to estimate the relationship between prenatal exposure to opioids and neurodevelopmental outcomes and examines potential sources of heterogeneity between the studies.

METHODS

We searched four databases through May 21st, 2022: PubMed, Embase, PsycInfo and the Web of Science according to a specified search strings. Study inclusion criteria include: (1) cohort and case-control peer-reviewed studies published in English; (2) studies comparing neurodevelopmental outcomes among children with prenatal opioid-exposure (prescribed or used non-medically) vs. an unexposed group. Studies investigating fetal alcohol syndrome or a different primary prenatal exposure other than opioids were excluded. Two main performed data extraction using "Covidence" systematic review platform. This systematic review was conducted in accordance with PRISMA guidelines. The Newcastle-Ottawa-Scale was used for quality assessment of the studies. Studies were synthesized based on the type of neurodevelopmental outcome and the instrument used to assess neurodevelopment.

RESULTS

Data were extracted from 79 studies. We found significant heterogeneity between studies due to their use of different instruments to explore cognitive skills, motor, and behavioral outcomes among children of different ages. The other sources of heterogeneity included: procedures to assess prenatal exposure to opioids; period of pregnancy in which exposure was assessed; type of opioids assessed (non-medical, medication used for opioid use dis-order, prescribed by health professional), types of co-exposure; source of selection of prenatally exposed study participants and comparison groups; and methods to address lack of comparability between exposed and unexposed groups. Cognitive and motor skills as well as behavior were generally negatively affected by prenatal opioid exposure, but the significant heterogeneity precluded a meta-analysis.

CONCLUSION

We explored sources of heterogeneity in the studies assessing the association between prenatal exposure to opioids and neurodevelopmental outcomes. Sources of heterogeneity included different approaches to participant recruitment as well as exposure and outcome ascertainment methods. Nonetheless, overall negative trends were observed between prenatal opioid exposure and neuro-developmental outcomes.

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